{"id":782175,"url":"https://alion.io/job/immunitybio-principal-scientist-upstream-process-science","title":"Principal Scientist, Upstream Process Science","company":{"id":449855,"name":"ImmunityBio","domain":"immunitybio.com","url":"https://alion.io/company/immunitybio","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":"lead","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Louisville, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":150000,"max":165000,"currency":"USD","period":"year","gross":null,"usd_annual":165000},"salary_estimate":null,"experience_years_min":12,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"Bioreactors","optional":false},{"name":"Cell Culture","optional":false},{"name":"Design of Experiments","optional":false},{"name":"GMP","optional":false}],"status":"live","first_seen_at":"2026-08-18T00:00:00Z","employer_posted_date":"2026-08-18","last_verified_at":"2026-10-28T22:02:28Z","board_verified":true,"closed_at":null,"days_open":72,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":72},"description":"Company Overview\n ImmunityBio is a vertically integrated commercial stage biotechnology company developing next-generation therapies that bolster the natural immune system to defeat cancers and infectious diseases. The Company’s range of immunotherapy and cell therapy platforms, alone and together, act to drive and sustain an immune response with the goal of creating durable and safe protection against disease. Designated an FDA Breakthrough Therapy, ANKTIVA is the first FDA-approved immunotherapy for non-muscle invasive bladder cancer CIS that activates NK cells, T cells, and memory T cells for a long-duration response. The Company is applying its science and platforms to treating cancers, including the development of potential cancer vaccines, as well as developing immunotherapies and cell therapies that we believe sharply reduce or eliminate the need for standard high-dose chemotherapy. These platforms and their associated product candidates are designed to be more effective, accessible, and easily administered than current standards of care in oncology and infectious diseases. \nWhy ImmunityBio?\n\n ImmunityBio is developing cutting-edge technology with the goal to transform the lives of patients with cancer and develop next-generation therapies and vaccines that complement, harness and amplify the immune system to defeat cancers and infectious diseases.\n\n Opportunity to join a publicly traded biopharmaceutical company with headquarters in Southern California.\n\n Work with a collaborative team with the ability to work across different areas of the company.\n\n Ability to join a growing company with professional development opportunities.\nPosition Summary\nThe Principal Scientist, Upstream Process Sciences role will manage the team responsible for upstream process development, process characterization, and scientific support activities for GMP manufacturing. This role serves as a technical expert for specific unit operations within the upstream manufacturing process, including both microbial and cell culture seed expansions and bioreactor operations across multiple cell lines. This role is also responsible for designing and executing process development experiments to design a robust and scalable clinical and commercial production process.\nEssential Functions\nLead and advise internal and external teams in development of efficient and robust microbial and cell culture production for whole cell products, viral vector, recombinant monoclonal antibodies, Fc-fusion, and other proteins for research, clinical, and commercial manufacturing.\nProvide high-level technical knowledge in the development of batch, fed batch, and perfusion processes for inoculum expansion and biologics production operations.\nManage the day-to-day activities of the team to include the hiring and training of new team members, coaching employees and monitoring performance\nProvide project coordination and high-level technical expertise in process development, process improvement, scale-up, and tech transfer activities.\nGuide and advise other technical staff in risk assessment, Design of Experiments (DOE), process characterization, process validation, and process monitoring activities.\nProvide input for development programs, and collaborate with discovery, formulation, analytical, quality, regulatory and manufacturing teams.\nDraft, review and approve technical protocols, reports, and manufacturing deviation investigations.\nPresent activities and results interdepartmentally, and to senior management.\nPerform ad-hoc and cross-functional duties and/or projects, as assigned, to support business needs and provide developmental opportunities.\nAuthor and review process-related regulatory submissions.\nConducts daily tasks associated with development and characterization of novel human therapeutics.\nResponsible for laboratory equipment maintenance programs.\nCreate, edit and adhere to Standard Operating Procedures (SOPs).\nPerforms ad-hoc and cross-functional duties and/or projects assigned to support business needs and provide developmental opportunities.\nEducation & Experience\nPh.D. in Cell Biology, Microbiology, Biology, or other life science or related field with 6+ years of experience in biopharmaceutical-based process development and/or GMP manufacturing operations including direct experience in upstream processes required; or\nMSc in Cell Biology, Microbiology, Biology, or other life science or related field with 9+ years of experience biopharmaceutical-based process development and/or GMP manufacturing operations including direct experience in upstream processes required; or\nBachelor’s degree in Cell Biology, Microbiology, Biology, or other life science or related field with 12+ years of biopharmaceutical-based process development and/or GMP manufacturing operations including direct experience in upstream processes required.\nPrevious supervisory experience strongly preferred\nKnowledge, Skills, & Abilities\nFundamental knowledge of cell and molecular biology, immunology, and/or virology\nPossess a high level of honesty and integrity, highly motivated and detail oriented.\nExpertise in developing upstream biopharmaceutical production processes.\nIn-depth knowledge of statistical design of experiments (DOE) used in process development.\nMaster-level technical knowledge of microbial, cell culture, and harvest operations affecting product quality.\nWorking knowledge of quality systems related to process development, clinical and commercial manufacturing.\nExcellent communication skills.\nAbility to advise and collaborate with colleagues within and across departments and corporate entities.\nFamiliarity with downstream purification operations.\nAdapts to rapidly changing work environment and shift in priorities.\nPossess strong written and verbal communication skills.\nStrong technical writing skills with experience preparing: SOPs, analytical test reports, work instructions, qualification/validation protocols, qualification/validation reports, and summary reports to support FDA and EMA filings\nWorking Environment / Physical Environment\nThis position works on site, in Louisville, CO.\nRegular work schedule is Monday - Friday, within standard business hours. Flexibility is available with manager approval.\nThis role works in both lab and cleanroom environments.\nOccasional travel may be required, up to 10%.\nThis position is eligible for a discretionary bonus and equity award. The annual base pay range for this position is below. The specific rate will depend on the successful candidate’s qualifications, prior experience as well as geographic location.\n$150,000 (entry-level qualifications) to $165,000 (highly experienced) annually\nThe application window is anticipated to close on 60 days from when it is posted or sooner if the position is filled or closed.\nImmunityBio uses artificial intelligence (AI) tools to assist with sourcing and identifying potential candidates for open positions. These tools help us reach qualified applicants and improve the efficiency of our recruitment outreach. No preference is given to applicants sourced or identified by AI tools.\nImportant: AI is not used to screen, evaluate, rank, assess, or make hiring decisions about applicants. All applications are reviewed by human recruiters and hiring managers. Hiring decisions are made solely by ImmunityBio personnel without automated decision-making.\nWe are committed to equal employment opportunity and ensure that all candidates are assessed based on their qualifications, skills, and experience through human review.\nImmunityBio employees are as valuable as the people we serve. We have built a resource of robust benefit offerings to best support the total wellbeing of our team members and their families. Our competitive total rewards benefits package, for eligible employees, include: Medical, Dental and Vision Plan Options\nHealth and Financial Wellness Programs\nEmployer Assistance Program (EAP)\nCompany Paid and Voluntary Life/AD&D, Short-Term and Long-Term Disability\nHealthcare and Dependent Care Flexible Spending Accounts\n401(k) Retirement Plan with Company Match\n529 Education Savings Program\nVoluntary Legal Services, Identity Theft Protection, Pet Insurance and Employee Discounts, Rewards and Perks\nPaid Time Off (PTO) includes: 11 Holidays\nExempt Employees are eligible for Unlimited PTO\nNon-Exempt Employees are eligible for 10 Vacation Days, 56 Hours of Health Pay, 2 Personal Days and 1 Cultural Day\nWe are committed to providing you with the tools and resources you need to optimize your Health and Wellness.\nAt ImmunityBio, we are an equal opportunity employer dedicated to diversity in the workplace. Our policy is to provide equal employment opportunities to all qualified persons without regard to race, gender, color, disability, national origin, age, religion, union affiliation, sexual orientation, veteran status, citizenship, gender identity and/or expression, or other status protected by law.","description_format":"text","description_chars":8969,"description_truncated":false,"requirements":{"experience_years_min":12,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity","Professional development","Retirement plans","Unlimited PTO","Wellness"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Cell & Gene Therapy","Biologics & Biosimilars","Oncology Therapeutics"],"lifecycle":[{"event":"open","at":"2026-09-12T00:59:56Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 9","filings_12m":9,"filings_prev_12m":3,"green_card_filings_12m":0,"median_offered_wage_usd":142500,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":18,"band":"cold","label":"Long shot","p_open":1,"p_active":0.638,"p_room":0.28,"age_days":71,"expected_fill_days":34,"reasons":["conf:0","win:tail","crowd:"],"computed_at":"2026-10-28T05:59:10Z"},"pay":{"stated_usd_annual":165000,"is_top_pay":true},"html_url":"https://alion.io/job/immunitybio-principal-scientist-upstream-process-science","json_url":"https://alion.io/job/immunitybio-principal-scientist-upstream-process-science.json","meta":{"generated_at":"2026-10-29T00:20:16Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":369,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-30T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":449855},"rest":"https://alion.io/mcp/rest/get_company?id=449855"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fimmunitybio-principal-scientist-upstream-process-science"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fimmunitybio-principal-scientist-upstream-process-science"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fimmunitybio-principal-scientist-upstream-process-science"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/immunitybio-principal-scientist-upstream-process-science\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fimmunitybio-principal-scientist-upstream-process-science"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":782175}},{"tool":"search_jobs","arguments":{"company":"immunitybio.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":782175},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. Docs: https://alion.io/developers"}}