{"id":762761,"url":"https://alion.io/job/immunome-principal-scientist-chemical-development","title":"Principal Scientist, Chemical Development","company":{"id":3828286,"name":"Immunome","domain":"immunome.com","url":"https://alion.io/company/immunome","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"A","score":88,"open_postings":4,"ghost_share":0,"stale_share":0.5,"repost_share":0,"time_to_fill_p50_days":38,"computed_at":"2026-10-28T05:59:10Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"lead","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Bothell, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":169593,"max":206233,"currency":"USD","period":"year","gross":null,"usd_annual":206233},"salary_estimate":null,"experience_years_min":7,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"GMP","optional":true}],"status":"live","first_seen_at":"2026-08-20T22:03:01Z","employer_posted_date":"2026-09-15","last_verified_at":"2026-10-29T04:00:32Z","board_verified":true,"closed_at":null,"days_open":69,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":69},"description":"Company Overview\nImmunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.\nPosition Overview\nWe are seeking an experienced Principal Scientist, Chemical Development to join our dynamic team to help advance our pipeline of innovative targeted cancer therapies. The successful candidate will apply their expertise in small molecule process development and manufacturing to support a variety of modalities in the Immunome pipeline with a focus on small molecule linker-payload targets for ADCs. This person will play a key role in leading challenging drug candidate process development programs, enabling treatment of patients in need. \nResponsibilities\nLeadership \nProvide technical leadership as a key member of the chemical development team while maintaining alignment with the company's goals and objectives. \nFunction as the technical lead on at least one program while also functioning as an individual technical contributor. \nProvide guidance and leadership to external partners working towards the successful advancement of antibody drug conjugates, radiopharmaceuticals, and other lead programs. \nSupport programs at the bench as an individual contributor as needed. \nTechnical Expertise \nLeverage knowledge and experience in the development and execution of robust and scalable small molecule synthetic processes. \nDevise and evaluate alternative routes of synthesis with the aim of developing robust and efficient routes to APIs while reducing cost of goods (COGs) and shortening manufacturing lead times. \nDevelop robust data packages for technical transfer of processes for manufacturing partners at external CMOs. \nMaintain knowledge of the current state of the art in synthetic methods utilized for the construction of complex molecules. \nCarry out thorough analytical data collection both as an individual contributor in the lab as well as via oversight and review of data collected at our external partners. \nContribute to authoring relevant sections of various regulatory documents (IND, IMPD, NDA, briefing books, etc.) and provide SME support for related regulatory inquiries. \nCross-Functional Collaboration \nExecute the integrated CMC regulatory strategies for pipeline programs. \nCollaborate with research, regulatory affairs, and CMC teams to ensure seamless coordination of activities. \nProvide feedback to research on synthetic routes and raw materials that are CMC friendly. \nFoster strong collaborations with internal and external stakeholders. \nEngage colleagues in discovery chemistry to provide CMC input of target molecules under evaluation for future development. \n Innovation \nStay abreast of the latest advancements in synthetic methodology as well as new technologies and methodologies to enhance our capabilities. \nAdvance Immunome’s intellectual property portfolio. \nQuality and Compliance \nEnsure compliance with relevant regulatory guidelines and industry standards for chemical development processes. \nUphold high-quality standards and address any compliance issues.\nQualifications\nPhD in Synthetic Organic Chemistry or similar with a minimum of 7 years of industry experience leading small molecule and/or linker-payload programs, or equivalent combination of education and experience. \nExperience as a technical lead overseeing tech transfer, process development and implementation of processes for manufacture at internal and/or external manufacturers is a plus. \nOccasional evening and/or weekend commitment. \nAbility to travel domestically and internationally (5-15%). \n Knowledge and Skills\nAbility to design cost effective robust manufacturing processes for complex small molecule targets as well as troubleshoot and solve complex technical challenges quickly. \nBrings a collaborative and open-minded attitude when working with various internal and external teammates. \nMeticulous and detail-oriented scientist with the ability to operate as an individual contributor at the bench while also managing external partners. \nProficient in generating robust and reliable analytical data utilizing various technologies in a hands-on capacity as well as evaluation of analytical data generated at external partners. \nProficient in writing technical reports and formulating presentations \nAbility to develop cross functional relationships with discovery chemistry and other pre-clinical groups. \nExperience in leading and managing technology transfers to third party process development and manufacturing partners. \nKnowledge of cGMP requirements and ICH guidelines related to CMC small molecule drug-substance development and manufacturing. \nTrack record of working closely with cross-functional teams in a biopharmaceutical or pharmaceutical environment. \nExcellent interpersonal and communication skills. \nWashington State Pay Range\n$169,593—$206,233 USD\nE/E/O\nImmunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.\nE-Verify\nImmunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).","description_format":"text","description_chars":5816,"description_truncated":false,"requirements":{"experience_years_min":7,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Oncology Therapeutics"],"lifecycle":[{"event":"open","at":"2026-09-11T18:59:32Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 3","filings_12m":3,"filings_prev_12m":1,"green_card_filings_12m":0,"median_offered_wage_usd":277500,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":21,"band":"cold","label":"Long shot","p_open":1,"p_active":0.588,"p_room":0.36,"age_days":68,"expected_fill_days":38,"reasons":["conf:4","win:tail","crowd:"],"computed_at":"2026-10-28T05:59:10Z"},"pay":{"stated_usd_annual":206233,"is_top_pay":true},"html_url":"https://alion.io/job/immunome-principal-scientist-chemical-development","json_url":"https://alion.io/job/immunome-principal-scientist-chemical-development.json","meta":{"generated_at":"2026-10-29T05:38:20Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":8719,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-30T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":3828286},"rest":"https://alion.io/mcp/rest/get_company?id=3828286"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fimmunome-principal-scientist-chemical-development"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fimmunome-principal-scientist-chemical-development"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fimmunome-principal-scientist-chemical-development"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/immunome-principal-scientist-chemical-development\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fimmunome-principal-scientist-chemical-development"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":762761}},{"tool":"search_jobs","arguments":{"company":"immunome.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":762761},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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