{"id":1523946,"url":"https://alion.io/job/inotiv-biotransformation-scientist","title":"Biotransformation Scientist","company":{"id":1996801,"name":"Inotiv","domain":"inotiv.com","url":"https://alion.io/company/inotiv","size_band":"201-500","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"B","score":76,"open_postings":17,"ghost_share":0,"stale_share":0.941,"repost_share":0,"time_to_fill_p50_days":23,"computed_at":"2026-10-22T06:10:10Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":null,"employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Saint Louis, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":60000,"max_usd":162000,"period":"year","method":"role_country_seniority_unknown","sample_n":3587},"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Chromatography","optional":false},{"name":"Mass Spectrometry","optional":false}],"status":"live","first_seen_at":"2026-09-02T00:00:00Z","employer_posted_date":"2026-09-02","last_verified_at":"2026-10-22T13:05:18Z","board_verified":true,"closed_at":null,"days_open":51,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":51},"description":"The Biotransformation Scientist will assist with the identification of enzymatic pathways that metabolize drug candidates in preclinical in vitro and in vivo models, including human tissue and cellular models (e.g., P450, non P450/AO/FMO, conjugative/UGT). Working primarily with preclinical species and human tissues/organ subcellular fractions, the individual will utilize contemporary mass spectrometry techniques (LC-MS/MS, HRMS) to identify and elucidate the structures of drug metabolites (small molecules, peptides, oligonucleotides). The individual will contribute to the development of in vitro-to-in vivo relationships related to drug clearance & half-life predictions. The individual will collaborate with Pharmacology and Toxicology laboratory leadership to establish Novel Approach Methodologies (NAMs) to address mechanistic inquiries and/or platform screening processes for same.\nJoin us in embracing research and science to impact the health and well-being of people all over the world.\nEssential Duties and Responsibilities\nDesign and execute laboratory studies aimed at identifying the enzymatic pathways that metabolize small molecule, peptide, and oligonucleotide therapeutics employing a contemporary approach methodology to establish the primary enzyme(s) contributing to the in vitro metabolism of a drug candidate(s). \nDesign and execute laboratory studies to elucidate primary drug clearance mechanisms in vitro, employing contemporary approach methodology to establish in vitro to in vivo correlations for anticipated drug clearance towards the prediction of human half life.\nDesign and collaborate with in vivo pharmacology & toxicology team members to execute ADME studies (non radiolabeled); elucidating the disposition of drug candidate molecules as it pertains to absorption, distribution, metabolism, and excretion; supplementing with in vitro protein binding, and blood distribution\nFor oligonucleotide and peptide molecules, design and execute in vitro studies aimed at elucidating the exonuclease/endonuclease and peptidase(s) metabolism of drug candidates, respectively.\nCollaborate with the Toxicology Department to establish cellular models of drug metabolism, induction, and predictive toxicologic mechanisms. \nSkills and Abilities\nExperience conducting in vitro and ex vivo biotransformation assays utilizing LC-MS/MS & HRMS techniques for quantitation and structure elucidation.\nExperience, skills, and abilities must include knowledge of contemporary bioanalytical techniques, including wet chemistry separations, liquid chromatography, and mass spectrometric analysis, instrument operation, and data processing. Knowledge of enzyme kinetics desirable.\nAbility to incorporate software in the maintenance of databases to collate and catalog records and inventory.\nIndependence in the laboratory and data work-up phases of research.\nA working knowledge and awareness of general laboratory procedures.\nGood written and oral communication skills.\nAbility to adhere to all safety regulations and procedures.\nEducation and Experience\nPhD in Organic Chemistry, Biochemistry, Analytical Chemistry or related discipline with 2-5 years direct industrial biotransformation experience following Post Doctoral training\nM.Sc. in a discipline previously described with 5-7 years direct industrial biotransformation experience\nWorking command of in vitro kinetic analysis and utilization of contemporary mathematical models to effectively analyze, interpret and/or model drug clearance, predicted half life, and drug-drug interactions\nAbility to perform mass spectrometry data collection, analysis and interpretation experience via LC-MS/MS\nCandidates possessing a command of Pharmacokinetic modeling, analysis, interpretation and simulation desirable\nPhysical Activity and Working Conditions\nWork is normally performed in a typical interior office work or laboratory environment\nWork environment involves exposure to potentially dangerous materials and situations that require following extensive safety precautions and may include use of protective equipment\nThe noise level is usually moderate\nThis position will frequently be involved with radiant/electrical energy, solvents, grease, oil, irritants, acids, bases, and other hazardous chemicals, electro-mechanical hazards, flammable materials and bio-hazards. Due to exposure to hazardous biological material (which may include HIV positive specimens), immunization to Hepatitis B and/or other diseases may be a requirement.\nSalary will be commensurate with experience and responsibilities. Benefits include health and dental coverage, short- and long-term disability, paid time off, paid parental leave, 401K participation with company match, and more!\nInotiv is an Equal Opportunity Employer. It is our policy to provide a fair and equal employment opportunity to all persons, regardless of age, race, color, religion, gender, gender identity, sexual orientation, physical or mental disability, national origin, veteran status, or any other basis prohibited by law. This policy governs all aspects of employment, including selection, job assignment, compensation, discipline, termination and access to benefits and training.\n*This position could be offered at different levels for candidates who qualify with a combination of advanced levels of education and/or years of experience. The salary range will adjust along with the level of the role to match the person’s relevant experience and/or education level.\nAt Inotiv, our work helps advance the development of new medicines and therapies that can improve people's lives. As a leading global contract research organization (CRO), we partner with researchers to tackle complex scientific challenges, drive innovation, and help build a healthier, safer world. Bringing together scientists, researchers, technical experts, and business professionals, we provide the expertise and collaboration needed to move research forward. Our people make this work possible, and we value the knowledge, ideas, and contributions each person brings to the team. Whether you are starting your career or bringing years of experience, Inotiv offers opportunities to learn, grow, and play a meaningful role in advancing treatments for patients around the world.\nSalary will be commensurate with experience and responsibilities. Benefits include health and dental coverage, short- and long-term disability, paid time off, paid parental leave, 401K, and more!\nInotiv is an Equal Opportunity Employer. It is our policy to provide a fair and equal employment opportunity to all persons, regardless of age, race, color, religion, sex, gender, gender identity, gender expression, sexual orientation, genetic information, disability, national origin, veteran status, or any other basis prohibited by law. 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