{"id":1192319,"url":"https://alion.io/job/isomorphic-labs-software-engineer-ml-infrastructure-london","title":"Principal Software Engineer (ML Infrastructure), London","company":{"id":48095,"name":"Isomorphic Labs","domain":"isomorphiclabs.com","url":"https://alion.io/company/isomorphic-labs","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"B","score":81,"open_postings":12,"ghost_share":0.083,"stale_share":0.25,"repost_share":0.167,"time_to_fill_p50_days":89,"computed_at":"2026-11-09T06:03:00Z"}},"role":"AI/ML","role_family":"AI/ML","seniority":"lead","employment_type":null,"work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["London, United Kingdom"],"countries":["GB"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":93000,"max_usd":246000,"period":"year","method":"role_country_seniority_unknown","sample_n":127},"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Machine Learning","optional":false},{"name":"Python","optional":false},{"name":"GCP","optional":true},{"name":"Kubernetes","optional":true}],"status":"live","first_seen_at":"2026-03-04T13:39:00Z","employer_posted_date":"2026-11-06","last_verified_at":"2026-11-09T11:28:20Z","board_verified":true,"closed_at":null,"days_open":249,"trust":{"level":"ok","repost_count":1,"flags":[],"days_open":249},"description":"Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.\nThe future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery. \nCome and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.\nThe world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you. \nAbout Iso\nIsomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.\nOur name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases.\nWe have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.\nEvery day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.\nYour impact \nThis is an exciting opportunity for a small number of innovative and versatile software engineers to work in a fast-paced and research-centric environment. \nYou will collaborate extensively with internal engineering and research teams to evolve the foundational infrastructure that makes it easy to train and deploy novel machine learning models over vast (and growing) pools of compute and data.\nFor this role we are looking for individuals with experience of designing and evolving complex systems at significant scale. Domain knowledge of ML inference, training or research infrastructure will be a strong advantage, though we encourage applications from candidates with a record of exceptional impact in any field.\nWhat you will do \nEvolve the ML infrastructure platform to accelerate both human and agent-driven research at scale\nExplore options to deploy agents to increase the robustness and reliability of the platform\nDevelop the platform to enable the next generation of distributed, performance-critical training and inference workloads \nPartner closely with engineering, research and product teams to identify and deliver impact\nSkills and qualifications \nEssential:\nDemonstrated ability to independently identify opportunities, deliver solutions and work effectively in cross-functional teams\nExperience building and evolving infrastructure or platforms at significant scale\nStrong Python programming (though familiarity with any particular library is not required)\nNice to have:\nDomain knowledge of ML inference, training or research infrastructure\nStrong hands-on experience building for Kubernetes\nExperience providing platforms to internal customers\nExperience with Google Cloud Platform (GCP)\nExperience with multi-cloud environments\n Culture and values\nWe are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it. \nThoughtful\n Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.\nBrave\n Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less.\nDetermined\n Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we.\nTogether\n Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere.\n Creating an extraordinary company\nWe believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.\nWe are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.\n Hybrid working\nIt’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call.\nPlease note that when you submit an application, your data will be processed in line with our privacy policy.\n>> Click to view other open roles at Isomorphic Labs","description_format":"text","description_chars":6174,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":null,"security_clearance":false,"languages":[]},"benefits":["Hybrid work"],"hiring_locations":[{"name":"United Kingdom","iso":"GB","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Artificial Intelligence","Drug Discovery","AI Research Labs","Drug Discovery AI"],"lifecycle":[{"event":"open","at":"2026-09-24T17:13:49Z"},{"event":"close","at":"2026-10-07T10:13:09Z"},{"event":"reopen","at":"2026-11-06T15:41:44Z"}],"visa":[{"country":"GB","licensed_sponsor":true,"adverts_offering_sponsorship_24m":0,"sanctioned_now":false,"evidence":"Licensed UK visa sponsor (Skilled Worker, Senior or Specialist Worker)","filings_12m":null,"filings_prev_12m":null,"green_card_filings_12m":null,"median_offered_wage_usd":null,"route":"Skilled Worker; Global Business Mobility: Senior or Specialist Worker","cap_exempt":false,"checked_at":"2026-11-09T07:32:21+00:00","sources":["UK Home Office: register of licensed sponsors (workers)"],"filings_for_role_12m":0}],"liveness":{"score":14,"band":"cold","label":"Long shot","p_open":1,"p_active":0.513,"p_room":0.28,"age_days":249,"expected_fill_days":89,"reasons":["conf:3","velocity","win:tail","crowd:"],"computed_at":"2026-11-09T06:03:00Z"},"pay":null,"html_url":"https://alion.io/job/isomorphic-labs-software-engineer-ml-infrastructure-london","json_url":"https://alion.io/job/isomorphic-labs-software-engineer-ml-infrastructure-london.json","meta":{"generated_at":"2026-11-09T13:29:28Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":17758,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-10T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.1,"usd":0.01,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":48095},"rest":"https://alion.io/mcp/rest/get_company?id=48095"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fisomorphic-labs-software-engineer-ml-infrastructure-london"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":2,"usd":0.2},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fisomorphic-labs-software-engineer-ml-infrastructure-london"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.1,"usd":0.01},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fisomorphic-labs-software-engineer-ml-infrastructure-london"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/isomorphic-labs-software-engineer-ml-infrastructure-london\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fisomorphic-labs-software-engineer-ml-infrastructure-london"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":1192319}},{"tool":"search_jobs","arguments":{"company":"isomorphiclabs.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":1192319},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. Docs: https://alion.io/developers"}}