{"id":1940732,"url":"https://alion.io/job/kardigan-senior-director-clinical-operations-program-lead","title":"Senior Director, Clinical Operations Program Lead","company":{"id":1889154,"name":"Kardigan","domain":"kardigan.bio","url":"https://alion.io/company/kardigan-bio","size_band":"201-500","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":null},"role":"Biotech","role_family":"Biotech","seniority":"head","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Princeton, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":247000,"max":322000,"currency":"USD","period":"year","gross":null,"usd_annual":322000},"salary_estimate":null,"experience_years_min":12,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"GCP","optional":false}],"status":"live","first_seen_at":"2026-10-06T01:02:47Z","employer_posted_date":"2026-10-21","last_verified_at":"2026-11-03T04:28:05Z","board_verified":true,"closed_at":null,"days_open":28,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":28},"description":"About Us \nKardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.\nIt is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.\nLed by Tassos Gianakakos, Jay Edelberg, M.D., Ph.D.,and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.\nWe have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients.\nAt Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families, we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic -leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn, we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.\nThese values are the foundation of our work, empowering us to make a real difference, every day.\nPosition Title: Sr. Director Clinical Operations Program Lead\nDepartment: Development\nReports To: Head of Clinical Operations\nLocation: Princeton, New Jersey \nJob Overview\nKardigan is seeking a Senior Director, Clinical Operations Program Lead for a late-stage cardiovascular asset. This position will be responsible for leading all of the activities associated with the clinical studies for the asset across all phases, including overseeing the internal operations team, CROs and vendors and working cross-functionally on the operational strategy and related initiatives. This position reports to the Head of Development Operations and serves as a member of the Development Operations Leadership team. This position will work collaboratively across the department, the entire Kardigan portfolio and cross-functional core/project teams with the overall goal of developing new and innovative treatments for cardiovascular diseases with unmet need.\nEssential Duties and Responsibilities:\nAccountable for the delivery of the assigned clinical program’s budget, timelines, and resource management with focus on quality, including making recommendations and decisions regarding operational strategies to support study and/or program objectives\nDevelop and present the operational strategy and plans including supply chain to effectively execute on the Clinical Development Plan\nPartner and collaborate with cross-functional stakeholders such as the Project Team Leader, Clinical Development Lead, Regulatory Lead, and other relevant stakeholders\nLead and oversee execution of first-in-human through phase 4 trials, depending on lifecycle of program, in compliance with ICH/GCP, local regulations, and Kardigan’s SOPs\nDrive the selection, oversight, and management of CROs and other vendors\nOversee site feasibility/capability assessments in collaboration with the CRO and cross-functional team\nOwn the strategy and execution of creative approaches to achieve Kardigan’s corporate goals. This may include innovative solutions to digital patient-oriented data capture and storage, the development and deployment of novel clinical research platforms and approaches, and the pursuit of collaborations that will enhance progress of Kardigan’s research programs\nReview and provide clinical operations input into relevant clinical documents such as the protocol, investigator brochure, regulatory documents, clinical study reports and other documents and plans as appropriate\nLead and provide oversight to the trial-specific operations team including the CROs/vendor(s) to function effectively and cohesively\nResponsible for representing Clinical Operations on cross-functional project teams and vendor/CRO operational meetings and ensuring compliance with operational standards and procedures.\nAlong with other Clinical Development personnel, represent Kardigan’s externally to Investigators, site staff, and Key Opinion Leaders\nPerform and document study level Sponsor Oversight of outsourced clinical activities\nCommunicate study-status, cost and issues to ensure timely decision-making by senior management\nOversee/collaborate on and contribute to inspection readiness activities that support audits and regulatory inspections related to clinical trial conduct\nMaintain oversight and participate in the creation/review/training/maintenance of departmental and organizational SOPs to ensure compliance\nLead and/or participate in Development Operations workstreams related to departmental and operating model related initiatives\nDevelop and foster strong, collaborative relationships with key stakeholders both within and external to Kardigan’s, including Prolaio\nDirectly manage assigned Clinical Trial Leads with a focus on performance, coaching and career development; provide mentorship to Site Operations Managers/Associates by providing clinical operations expertise and support identification and prioritization of study and program level work.\nStrive for continuous improvement and more efficient ways of working in clinical development\nQualifications and Preferred Skills\nMinimum of BA/BS with at least 12 years of global clinical trial and clinical program experience, including 6+ years of high complexity independent, global trial management experience. Advanced degree preferred.\nExperience within the field of cardiovascular or rare disease studies is preferred.\nRobust experience in early and late phase drug development; some late-stage development experience is required.\nMulti-dimensional Clinical Operations background with capability of devising plans for operational challenges such as site activation, subject enrollment, monitoring oversight, protocol deviation management, data cleaning, etc.\nCross-Collaboration proficiency with other therapeutic areas and functions such as Regulatory, CMC, Biostatistics, Data Management, Finance, Program Management, etc.\nProven track record of effective leadership and team-building skills in the context of a multi-disciplinary team in the biotech or pharmaceutical industry\nExperience in ICH/GCP inspections, audits and inspection preparedness\nOutstanding communication skills, both verbal and written\nExcellent organizational skills and ability to work independently\nConfidence to challenging status-quo thinking and behavior; can work with agility and an innovative mindset.\nExact Compensation may vary based on skills, experience and location.\nPay range\n$247,000—$322,000 USD","description_format":"text","description_chars":7129,"description_truncated":false,"requirements":{"experience_years_min":12,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Health Care","Drug Discovery","Cardiometabolic Therapeutics"],"lifecycle":[{"event":"open","at":"2026-10-06T02:43:14Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 2","filings_12m":2,"filings_prev_12m":1,"green_card_filings_12m":0,"median_offered_wage_usd":152500,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":77,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.86,"p_room":0.9,"age_days":28,"expected_fill_days":63,"reasons":["conf:1","win:mid"],"computed_at":"2026-11-03T05:54:40Z"},"pay":{"stated_usd_annual":322000,"is_top_pay":true},"html_url":"https://alion.io/job/kardigan-senior-director-clinical-operations-program-lead","json_url":"https://alion.io/job/kardigan-senior-director-clinical-operations-program-lead.json","meta":{"generated_at":"2026-11-03T08:48:33Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":12481,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-04T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":1889154},"rest":"https://alion.io/mcp/rest/get_company?id=1889154"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fkardigan-senior-director-clinical-operations-program-lead"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fkardigan-senior-director-clinical-operations-program-lead"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fkardigan-senior-director-clinical-operations-program-lead"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/kardigan-senior-director-clinical-operations-program-lead\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fkardigan-senior-director-clinical-operations-program-lead"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":1940732}},{"tool":"search_jobs","arguments":{"company":"kardigan.bio","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":1940732},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. Docs: https://alion.io/developers"}}