{"id":1014199,"url":"https://alion.io/job/kcas-bio-sr-scientist-biomarker-method-development","title":"Sr Scientist – Biomarker Method Development","company":{"id":678933,"name":"KCAS Bio","domain":"kcasbio.com","url":"https://alion.io/company/kcasbio","size_band":"201-500","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Lever","truth_index":{"grade":"B","score":75,"open_postings":3,"ghost_share":0,"stale_share":1,"repost_share":0,"time_to_fill_p50_days":33,"computed_at":"2026-11-05T05:54:30Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Kansas City, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":79000,"max_usd":157000,"period":"year","method":"role_seniority_country_remote_cell","sample_n":1015},"experience_years_min":5,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"ELISA","optional":false},{"name":"GLP","optional":true}],"status":"live","first_seen_at":"2026-09-17T20:56:04Z","employer_posted_date":"2026-09-17","last_verified_at":"2026-11-05T18:16:50Z","board_verified":true,"closed_at":null,"days_open":49,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":49},"description":"When you work as a Sr. Scientist in the BioPharma Sciences group at KCAS, you get to further our mission by leveraging your knowledge in bioanalytical and scientific principles with a primary focus on biomarker method development. You will design, develop, optimize, and troubleshoot complex bioanalytical methods while utilizing your strong base in scientific principles and theories to assess assay performance, data integrity, and scientific outcomes.\nOur BioPharma Sciences team uses ligand binding assay (LBA) platforms to conduct bioanalytical testing in support of drug discovery, preclinical, and clinical studies, including the quantification of proteins, biomarkers, and anti-drug antibodies in biological matrices using technologies such as ELISA, MSD, and other immunoassay-based methods.\nIn this role, we will rely on you to:\nLead the design, development, optimization, and troubleshooting of ligand binding assays with a primary focus on biomarker method development\nDesign experiments and independently evaluate assay performance to establish robust and scientifically appropriate methods\nDevelop and optimize assay conditions, reagents, controls, and workflows to address complex biomarker method development challenges\nApply strong scientific judgment to evaluate assay performance characteristics, including precision, accuracy, sensitivity, selectivity, specificity, and robustness\nTroubleshoot complex assay performance issues, identify root causes, and develop scientifically sound solutions\nSupport method qualification, validation, and transfer activities as appropriate for the intended use of the assay\nContribute scientific expertise to PK and immunogenicity/ADA method development activities as applicable\nAct as a technical expert and scientific resource for biomarker assay development, performance, troubleshooting, and problem solving\nAct as lead scientist, help design experiments, and provide work instructions and technical training to more junior scientific staff\nReview and interpret scientific data and communicate findings, recommendations, and potential risks to internal teams and clients\nPartner with clients and internal stakeholders to understand scientific objectives and translate those needs into appropriate bioanalytical strategies\nPrepare and review study documentation, data summaries, protocols, and reports as appropriate\nWork collaboratively with Quality Assurance and scientific teams to ensure activities are conducted in accordance with applicable protocols, SOPs, regulatory requirements, and quality standards\nMaintain knowledge of current scientific, technological, and regulatory developments relevant to biomarkers and ligand binding assay development\nBe responsible for timeline adherence and communication of status to management as required\nPerform all aspects of the job in a way that supports company brand and supports company mission, vision, and values\nTo qualify specifically for this role, you will have:\nBachelor’s, Master’s, or PhD in Biology, Biochemistry, Immunology, or related scientific field with at least 5 years of experience in a bioanalytical laboratory environment\nDemonstrated depth of experience in biomarker method development, including the development, optimization, and troubleshooting of biomarker assays\nStrong hands-on experience with ligand binding assays (LBA), including ELISA, MSD, or similar immunoassay platforms\nDemonstrated ability to independently design experiments, evaluate assay performance, troubleshoot complex technical challenges, and optimize assay conditions\nStrong understanding of assay performance characteristics, including precision, accuracy, sensitivity, selectivity, specificity, and robustness\nExperience with method development, qualification, and/or validation in a regulated bioanalytical, pharmaceutical, biotechnology, or CRO environment\nStrong scientific judgment and the ability to interpret complex data and make recommendations based on experimental outcomes\nExperience working within established regulatory and quality frameworks applicable to bioanalytical method development\nStrong written and verbal communication skills with the ability to communicate complex scientific information to internal and external stakeholders\nAbility to provide technical guidance, training, and mentorship to less experienced scientific staff \nPreferred Qualifications:\nExperience developing PK ligand binding assays\nExperience developing immunogenicity/anti-drug antibody (ADA) assays\nExperience working in a GLP-regulated bioanalytical laboratory environment\nExperience interacting with Quality Assurance and supporting regulated studies, audits, or inspections\nExperience in a CRO environment\nPrior experience serving as a technical lead or scientific lead for assay development 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