Upstream Process Development Co-Op

At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients.

Job Summary

This role is responsible for media and feed preparation, execution of experiments for upstream biologics process development, routine daily maintenance of upstream equipment, and experiment data management and analysis.  Organizational skills, communication skills, and recordkeeping are also critical to this role.

Primary Responsibilities: 

• CHO mammalian cell cultures in shaker flasks, WAVE bioreactors, and benchtop bioreactors
• Media and feed formulation as needed for experiments
• Data management and analysis including metabolite, gas, cell count, and titer data
• Media and feed studies to support process development on early phase programs
• Scale-down modeling and range finding to support development and program technology transfers
• Depth filtration filter loading studies to develop cell culture harvest strategies
• Routine maintenance on upstream equipment to maintain daily functionality

Core Competencies (Required Skills)

• Familiar with aseptic technique methods
• Familiar with experiment design
• Familiar with Microsoft Office, especially Microsoft Excel
• Technical and scientific writing and presentation skills

Preferred Skills  

• Mammalian cell culture
• Media and buffer preparation
• Understanding of basic engineering and biology concepts

Education Requirements

• Currently enrolled in a chemical engineering, bioengineering, molecular biology or related program to earn a Bachelor of Science degree or equivalent

This pay range represents the base hourly rate or base annual full-time salary for all positions in the job grade within which this position falls. The actual base salary offer will depend on a variety of factors including experience, education, and other relevant factors. 

Potential base pay range

$28—$32 USD

Our Diversity, Equity & Inclusion Mission Statement:  Keros is an inclusive company.  We believe that diversity drives innovation.  We continue to build an inclusive culture that encourages, supports, and celebrates the diverse voices of our employees.  As such, Keros takes a holistic approach in mentoring, coaching, and developing all of our Keros team members.

Keros Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Recruitment & Staffing Agencies:

Keros Therapeutics does not accept unsolicited resumes from any source other than the candidate directly.  Any unsolicited submission by an agency to Keros is prohibited.  Any resume submitted by an agency without a signed contract or expressed consent by a member of the Keros Therapeutics Human Resources Department, will be considered property of Keros Therapeutics, and no fee shall be owed with respect thereto.