{"id":3090021,"url":"https://alion.io/job/ki-postdoctoral-researcher-in-single-cell-epigenetics","title":"Postdoctoral Researcher in Single-Cell Epigenetics","company":{"id":15288,"name":"Karolinska Institutet","domain":"ki.se","url":"https://alion.io/company/ki-se","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Varbi","truth_index":null},"role":"AI/ML","role_family":"AI/ML","seniority":null,"employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Solna, Sweden"],"countries":["SE"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Multimodal AI","optional":false},{"name":"Python","optional":false},{"name":"Single-Cell Sequencing","optional":false}],"status":"live","first_seen_at":"2026-10-21T22:00:00Z","employer_posted_date":"2026-10-22","last_verified_at":"2026-10-31T20:13:23Z","board_verified":true,"closed_at":null,"days_open":10,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":10},"description":"Do you want to contribute to top quality medical research?\nThe Lambo research team at the department of Oncology-Pathology (OnkPat) is an exciting new research group that studies the epigenetic mechanisms by which tumors adapt to treatment. We use cutting edge experimental and computational methods to study epigenetics, in particular methods that utilize single cell sequencing technologies, which includes new technologies to generate single cell DNA methylation at scale. We are an interdisciplinary group that combines experimental perturbations, computational analysis and AI modelling with the goal to bridge the gap between basic tumor biology and clinical implementation. As a postdoctoral researcher at our team, you have the exciting opportunity to explore a largely uncharted field of research, to pursue your own ideas and to make the next step in your career.\nA creative and inspiring environment with wide-ranging expertise and interests\nThe Department of Oncology-Pathology is a department where preclinical and clinical cancer research are tightly interconnected. More than 35 research groups form a dynamic and strong research environment with a common goal to improve diagnostics, treatments, and quality of life for patients with cancer. Our facilities are located at Bioclinicum within the Karolinska University Hospital while part of the department is located within theScience for Life Laboratory. This provides access to advanced technologies including genomics, proteomics, metabolomics, spatial biology, cellular and molecular imaging, and bioinformatics. Our close connection withThe Swedish Childhood Tumor Biobank, The Theranostic Trial Center, and The Karolinska Comprehensive Cancer Center, enable pre-clinical and clinical scientists to engage in collaborative projects for early clinical testing of precision therapies, to enhance cancer diagnostics, to facilitate early detection and to develop innovative clinical trials in cancer patients.\nYour mission\nThe position involves generating, processing and analyzing single cell methylation data for pediatric cancers, in particular pediatric acute myeloid leukemia. The postdoc will be involved in setting up a recently developed method for generating single cell DNA methylation at scale and use the resulting data to study pediatric tumor evolution. Because of the novelty of the data type there are opportunities to develop and publish new computational approaches to work with this data and study tumor biology.\nKey duties include:\nFacilitate setting up single cell methylation at scale\nProcessing and maintaining large sequencing datasets\nDeveloping new computational approaches for characterizing cell states and shifts in cell states based on DNA methylation\nDeveloping new computational approaches for identifying biologically relevant mechanisms\nWorking together as a team with experimental biologists to guide the generation hypotheses, place biological findings in context and to validate findings\nPerforming multimodal integration using other data modalities\nData interpretation and generating new testable hypotheses\nBe responsible for study design, computational methods, writing, data visualization, manuscript preparation, presenting and managing of data involved in publications\nYour profile\nTo be eligible for employment as a postdoctoral researcher, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier.\nQualifications and experience:\nDocumented experience in analyzing single-cell, single-nucleus and/or epigenetic datasets\nStrong programming skills in R and/or Python\nExperience handling large and complex biological datasets\nExperience with key analytical tasks including alignment, quality control, data integration, and biological interpretation\nThe ability to develop and troubleshoot computational approaches, ensure reproducibility and critically interpret results\nDocumented experience of being able to successfully disseminate research i.e. through national/ international conferences\nGood communication skills in English and the ability to work in an interdisciplinary environment\nAdditional merits:\nExperience in generating single cell sequencing libraries\nExperience working in the wet lab\nExperience working with pediatric cancer data\nDocumented experience in working with/studying DNA methylation\nKnowledge/experience in epigenetic regulation of developmental biology\nDocumented experience in generating computational workflows i.e. published packages or bioinformatic tools\nApplicants having a multidisciplinary background (both wet lab and computational experience) are prioritized for this position. Having experience with pediatric cancer and DNA methylation is preferred but not required.\nWhat do we offer?\nA creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.\nLocation: BioClinicum, Solna\nChoose to work at KI - Ten reasons why\nApplication\nAn employment application must contain the following documents in English or Swedish:\nPhD certificate\nA complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work\nA complete list of publications\nA summary of current work (no more than one page)\nKI applies individual and differentiated salary setting in accordance with our collective agreements RALS and RALS-T\nThe application is to be submitted through the Varbi recruitment system. At the latest 12th October.\nThis position is for 2 years with the possibility of extension.\nWant to make a difference? Join us and contribute to better health for all!","description_format":"text","description_chars":6754,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":true},"security_clearance":false,"languages":[{"language":"Swedish","level":"All levels","optional":false},{"language":"English","level":"All levels","optional":false}]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Higher Education","Research Institutes","Medical Education & Training"],"lifecycle":[{"event":"open","at":"2026-10-22T14:37:41Z"}],"visa":[],"liveness":{"score":81,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.859,"p_room":0.945,"age_days":9,"expected_fill_days":22,"reasons":["conf:0","velocity","win:mid"],"computed_at":"2026-10-31T05:58:55Z"},"pay":null,"html_url":"https://alion.io/job/ki-postdoctoral-researcher-in-single-cell-epigenetics","json_url":"https://alion.io/job/ki-postdoctoral-researcher-in-single-cell-epigenetics.json","meta":{"generated_at":"2026-10-31T22:39:46Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":35363,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-01T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":15288},"rest":"https://alion.io/mcp/rest/get_company?id=15288"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fki-postdoctoral-researcher-in-single-cell-epigenetics"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fki-postdoctoral-researcher-in-single-cell-epigenetics"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fki-postdoctoral-researcher-in-single-cell-epigenetics"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/ki-postdoctoral-researcher-in-single-cell-epigenetics\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fki-postdoctoral-researcher-in-single-cell-epigenetics"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3090021}},{"tool":"search_jobs","arguments":{"company":"ki.se","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3090021},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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