{"id":3034876,"url":"https://alion.io/job/latchbio-ai-biologist-biologics-development","title":"AI Biologist - Biologics Development","company":{"id":171847,"name":"LatchBio","domain":"latch.bio","url":"https://alion.io/company/latchbio","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Ashby","truth_index":{"grade":"B","score":75,"open_postings":6,"ghost_share":0,"stale_share":1,"repost_share":0,"time_to_fill_p50_days":null,"computed_at":"2026-10-29T05:49:05Z"}},"role":"Biotech","role_family":"Biotech","seniority":null,"employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":120000,"max":180000,"currency":"USD","period":"year","gross":null,"usd_annual":180000},"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":true,"relocation_package":false,"has_equity":false,"technologies":[{"name":"AI Agents","optional":false},{"name":"Antibody Engineering","optional":false},{"name":"Claude","optional":false},{"name":"Cursor","optional":false},{"name":"Mass Spectrometry","optional":false},{"name":"Python","optional":false},{"name":"Structured Outputs","optional":false}],"status":"live","first_seen_at":"2026-10-20T01:07:12Z","employer_posted_date":"2026-10-20","last_verified_at":"2026-10-29T21:55:18Z","board_verified":true,"closed_at":null,"days_open":10,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":10},"description":"AI Biologist - Biologics Development\nLatch builds rigorous scientific benchmarks (benchmarks.bio) for AI agents across biology. We work with frontier labs and pharma to measure whether agents can handle real biological workflows: the messy, multi-layer reasoning that matters in the field.\nWe’re seeking an AI Biologist to join our TxBench team, pushing what AI can achieve in therapeutic antibody development.\nAbout the Role. You will be the scientific authority on ground truth, testing whether agents can reason like an expert biologics development scientist. The benchmark covers monoclonal antibodies, Fc-fusions, and bispecifics in the window after lead nomination and before IND. AI agents today struggle to interrogate raw analytical traces and preclinical data, separate real quality-attribute failures from analytical artifacts, and make advance, engineer, or kill calls an expert would stand behind. You will work with software engineers and scientists to build the tasks and datasets behind our benchmarks. Your judgment will set the standard agent outputs are held to, including:\nBuild the task\nTurn real development workflows into file-based tasks with structured outputs and deterministic grading: developability triage, analytical/CMC characterization, PK and FcRn reasoning, immunogenicity, effector function and safety, and first-in-human dose projection\n\nWrite gold-standard answers from raw data, with tolerances that reflect real replicate, integration, and fitting variability\n\nCurate data fixtures: developability panels, glycan LC-MS, charge-variant CE, intact/subunit MS, SEC-MALS, FcRn/FcγR sensorgrams, concentration-time PK, and immunogenicity and effector assays\n\nPartner with software engineers to turn your judgment into new workflows\n\nSet the hard calls\nTest whether agents can tell a real liability from an artifact, such as a co-eluting glycan peak, a misassigned charge variant, or a single assay flag not confirmed by orthogonal readouts\n\nTest whether agents match effector function and affinity to the mechanism, rather than assuming “more is better”\n\nTest whether agents distinguish linear from target-mediated clearance, and judge a molecule against its target product profile\n\nJudge the agent\nInterrogate agent reasoning step by step, and challenge conclusions that sound right but wouldn’t survive a development review or go/no-go decision\n\nPinpoint where agents go wrong: why a step fails, what an expert would do instead, and what evidence would change the call\n\nScore agent confidence, rewarding explicit uncertainty over overconfident calls\n\nRequirements\nPhD in protein engineering, biochemistry, analytical chemistry, pharmacology, or a related field\n\nHands-on analysis of antibody development data. You’ve done the analysis yourself, not just supervised it\n\nDeep expertise in at least one area (analytical/CMC characterization, large-molecule DMPK, protein engineering and developability, or non-clinical safety) and working fluency across the others\n\nCommand of how readouts map to critical quality attributes, PK and effector properties, and release or comparability decisions\n\nPython or R for data analysis, including parsing chromatograms and electropherograms, kinetic fitting, or PK modeling\n\nAI-ready from day one: daily use of Claude, Cursor, or similar agents, with the judgment to spot where model reasoning is technically correct but scientifically unsound\n\nConfidence to overrule an AI agent when the evidence demands it, and the openness to update when shown wrong\n\nAbility to calibrate confidence and communicate uncertainty rather than defaulting to binary calls\n\nBonus: antibody format and Fc engineering experience (IgG subclasses, YTE/LS, effector-silencing, bispecific architectures)\n\nBonus: familiarity with MAM, ICH Q6B/Q5E, FDA immunogenicity guidance, IMGT, SAbDab, and IEDB\n\nCulture. We practice radical transparency: you’ll know how the company is doing, what’s working, and what isn’t. It’ll always be us against the problem, never each other. We’re opinionated but respectful, and we bring solutions with our problems. You decide how you work; we judge the output. We use AI constantly, so what we reward is original expert judgment, not AI output passed off as your own. You’ll start on the bench that fits your expertise and can move across teams as you build a track record. People who do well here and bring leadership experience can move quickly into senior roles. Outside of work, we have company outings most months, team off-sites, a Latch run club, cycling, boxing, ice skating, and soccer. Feel free to add to the list.\nCompensation & Logistics\nContract: 1099 (or W-8BEN internationally), no end date\n\nPay: guaranteed for weeks 1-4 while you ramp, then paid per certified task. Most people in this position earn $120K-$180K+ (uncapped upside); certify twice the tasks/week, earn twice the pay that week.\n\nCommitment: full-time, on your own schedule. Most of the team works 40+ hours a week.\n\nMeetings: a few pod check-ins a week. The rest of your time is yours.\n\nLocation: remote (anywhere), hybrid, or onsite in SF. We prefer onsite.\n\nOnsite perks: catered lunch and dinner daily, a waterfront office in Mission Bay, and monthly parking when available\n\nWork authorization: US citizens, permanent residents, and OPT holders. We can’t support STEM OPT extensions or sponsorship.\n\nInterview Process\nWe move fast: about 2-3 weeks from your first call, to offer.\nIntro Screen - Latch Talent Team\n\nTake-Home Project - HackerRank\n\nTechnical Interview - Member of Technical Staff\n\nCulture Interview - C-Suite\n\nOffer","description_format":"text","description_chars":5592,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Biologics & Biosimilars","Bioinformatics","Scientific & Lab Software"],"lifecycle":[{"event":"open","at":"2026-10-21T21:11:14Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 5","filings_12m":5,"filings_prev_12m":1,"green_card_filings_12m":0,"median_offered_wage_usd":112500,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":83,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.828,"p_room":1,"age_days":9,"expected_fill_days":30,"reasons":["conf:1","velocity","win:early"],"computed_at":"2026-10-29T05:49:05Z"},"pay":{"stated_usd_annual":180000,"is_top_pay":false},"html_url":"https://alion.io/job/latchbio-ai-biologist-biologics-development","json_url":"https://alion.io/job/latchbio-ai-biologist-biologics-development.json","meta":{"generated_at":"2026-10-30T01:07:13Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":1524,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-31T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":171847},"rest":"https://alion.io/mcp/rest/get_company?id=171847"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Flatchbio-ai-biologist-biologics-development"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Flatchbio-ai-biologist-biologics-development"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Flatchbio-ai-biologist-biologics-development"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/latchbio-ai-biologist-biologics-development\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Flatchbio-ai-biologist-biologics-development"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3034876}},{"tool":"search_jobs","arguments":{"company":"latch.bio","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3034876},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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