{"id":766927,"url":"https://alion.io/job/legend-biotech-senior-engineer-principal-engineer-lentivirus-downstream-process-development","title":"Senior Engineer / Principal Engineer, Vector Downstream","company":{"id":12179,"name":"Legend Biotech","domain":"legendbiotech.com","url":"https://alion.io/company/legend-biotech","size_band":"501-1000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"A","score":92,"open_postings":3,"ghost_share":0,"stale_share":0.333,"repost_share":0,"time_to_fill_p50_days":57,"computed_at":"2026-10-30T05:48:23Z"}},"role":"Industrial Engineering","role_family":"Industrial Engineering","seniority":"lead","employment_type":null,"work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"explicit","locations":["Somerset, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":5000000,"max":null,"currency":"INR","period":"year","gross":null,"usd_annual":53090},"salary_estimate":null,"experience_years_min":8,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Chromatography","optional":false},{"name":"GMP","optional":false},{"name":"MATLAB","optional":false},{"name":"Python","optional":false}],"status":"live","first_seen_at":"2026-09-11T19:49:47Z","employer_posted_date":"2026-10-01","last_verified_at":"2026-10-30T17:42:01Z","board_verified":true,"closed_at":null,"days_open":49,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":49},"description":"Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide.\nLegend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.\nLegend Biotech is seeking a Senior Engineer / Principal Engineer, Vector Downstream as part of the Technical Development team based in Somerset, NJ.\nRole Overview\nThe Senior Engineer / Principal Engineer, Vector Downstream will be responsible for designing, optimizing, and scaling purification processes for lentiviral vectors (LVV) within our innovative pipeline. This role focuses on delivering high-quality vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will drive scientific excellence in scaling automation capabilities from concept to operation, integrating analytics and modeling into downstream workflows, and translating microscale insights into robust, scalable processes for GMP manufacturing. The level and scope of responsibility will be determined based on the candidate's experience, technical expertise, and demonstrated impact.\nKey Responsibilities\nBuild state-of-the-art mechanistic and hybrid models that directly influence the development of LVV downstream processing, building operational efficiency through model-first and AI-enabled development strategies.\nApply core engineering concepts including mass transfer, fluid mechanics, and thermodynamics to build robust in silico process models.\nPerform data analytics using ML algorithms for modeling and clustering to generate process insights.\nWorking closely with the team to implement development and optimization of downstream processes including clarification (depth filtration, centrifugation), chromatography (AEX, SEC, HIC), and Tangential Flow Filtration (TFF).\nLead or support the translation of bench-scale processes to GMP manufacturing, ensuring seamless technology transfer and providing troubleshooting support during clinical production runs.\nDesign/Implement different Advanced Process Control (APC) strategies (e.g., MPC, State Estimators) to optimize process performance.\nCommunicate potential issues and delays along with solutions and mitigation approaches.\nIn collaboration with senior leaders and cross-functional partners, identify project acceleration opportunities.\nLeverage advanced science and technology to maximize vector recovery, purity, and potency.\nProvide technical guidance and collaborate with scientists and cross-functional team members in the execution of project-specific activities.\nAuthor and serve as a primary reviewer for technical documents, including development reports, SOPs, and CMC sections for regulatory submissions.\nWork closely with Upstream Process Development and Analytical Development teams to ensure integrated process outcomes.\nTech transfer process to/from other Legend sites or CDMOs.\nProactively identify technical challenges and drive effective solutions and mitigation strategies.\nEnsure compliance with regulatory requirements.\nRequirements\nAdvanced degree (PhD preferred, or MS) in Chemical Engineering, Biomedical Engineering, Bioprocess Engineering, or a related field.\n6+ years (PhD) or 8+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting. Candidates with additional experience and demonstrated technical leadership may be considered at the Principal Engineer level.\nStrong engineering knowledge of bioprocess modeling/simulation and the interaction of biomolecules, materials, and machinery.\nExperience with modeling software and programming languages such as Python and/or MATLAB preferred.\nStrong technical experience in purification, chromatography, and TFF, with demonstrated expertise in downstream process development.\nUnderstanding of GMP manufacturing requirements and CMC strategies for clinical-stage product development.\nExperience with lentiviral vector technologies preferred. Candidates with relevant viral vector, biologics, gene therapy, or advanced therapy process development experience will also be considered.\nStrong communication, collaboration, leadership, and problem-solving skills with the ability to influence cross-functional teams and navigate complex development timelines.\nCreative and strategic thinking.\nStrong troubleshooting skills.\nPreferred experience in developing vector processes tailored for in vivo CAR-T generation and systemic delivery.\nPreferred experience in large-scale (>50L) purification processes.\nLanguage(s): English. Mandarin is a plus.\nThe base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws.\nOther Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles.\nBenefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.\nPay Range (Base Pay):\n$146,410—$192,164 USD\nPlease note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.\nWork Authorization & Employment Eligibility\nApplicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.\nEEO Statement\nIt is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.\nEmployment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.\nFor information related to our privacy notice, please review: Legend Biotech Privacy 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