{"id":285511,"url":"https://alion.io/job/legend-biotech-sr-scientist-lentivirus-upstream-processing","title":"Sr. Scientist, Lentivirus Upstream Processing","company":{"id":12179,"name":"Legend Biotech","domain":"legendbiotech.com","url":"https://alion.io/company/legend-biotech","size_band":"501-1000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"A","score":92,"open_postings":3,"ghost_share":0,"stale_share":0.333,"repost_share":0,"time_to_fill_p50_days":57,"computed_at":"2026-10-29T05:49:05Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"explicit","locations":["Somerset, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":5000000,"max":20000000,"currency":"INR","period":"year","gross":null,"usd_annual":212360},"salary_estimate":null,"experience_years_min":8,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Bioreactors","optional":false},{"name":"Cell Culture","optional":false},{"name":"GMP","optional":false}],"status":"live","first_seen_at":"2026-09-01T20:59:35Z","employer_posted_date":"2026-10-01","last_verified_at":"2026-10-30T00:20:18Z","board_verified":true,"closed_at":null,"days_open":58,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":58},"description":"Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide.\nLegend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.\nLegend Biotech is seeking a Sr. Scientist, Lentivirus Upstream Processing as part of theTechnical Development team based in Somerset, NJ.\nRole Overview\nThe Senior Scientist, Lentivirus Upstream Process Development, will be a core technical contributor responsible for designing, executing, and optimizing upstream production processes for lentiviral vectors (LVV) within our innovative pipeline. This role focuses on delivering high-quality, high-titer vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will apply technical expertise in upstream processing (USP)-including seed train optimization, mammalian cell culture (HEK293/HEK293T), large-scale transient transfection, and bioreactor scale-up-to ensure processes are robust, scalable, and phase-appropriate for GMP manufacturing. This position demands a blend of hands-on technical mastery and strong analytical thinking to support project timelines while maintaining a patient-focused approach.\nKey Responsibilities\nDesign and execute experimental strategies for lentiviral vector upstream production.\nPerform development and optimization of upstream processes, including seed train expansion, suspension mammalian cell culture (HEK293/HEK293T), plasmid transient transfection optimization, and feed batch/perfusion bioprocessing in stir-tank and rocker bioreactors.\nSupport the establishment and validation of bioreactor scale-up and scale-down models to ensure process comparability and predictability.\nSupport the translation of bench-scale processes to GMP manufacturing, assisting in technology transfer and providing troubleshooting support during clinical production runs.\nExecute study protocols to define operating parameters, feeding strategies, and performance limits; maintain accurate documentation for USP data.\nCommunicate technical findings, issues, and potential delays to project leads in a timely manner.\nCollaborate with cross-functional team members, including CMC Project Management and other technical leads, to support project goals.\nApply scientific knowledge and technology to optimize vector titer, specific productivity, and quality.\nSupport team activities by providing technical guidance to junior staff, fostering a culture of scientific rigor and continuous improvement.\nAuthor and review technical documents, including development reports, SOPs, and relevant sections for regulatory submissions (IND).\nWork closely with Downstream Process Development and Analytical Development teams to ensure integrated process outcomes.\nSupport tech transfer activities to/from other Legend sites or CDMOs.\nEnsure compliance with all internal and regulatory requirements.\nRequirements\nAdvanced degree (PhD preferred, or MS) in Chemical Engineering, Bioengineering, or a related field.\nExperience: 5-8 years (PhD) or 8+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting\nHands-on experience in mammalian cell culture (HEK293, HEK293T), seed train expansion, feeding strategy, and transient transfection optimization specifically for viral vectors (Lentivirus preferred).\nDemonstrated proficiency in developing and implementing bioreactor scale-up and scale-down models.\nSolid understanding of GMP manufacturing requirements and CMC strategies for early-phase clinical trials.\nDirect experience with cell and lentiviral vector technologies within the current emerging field.\nWorking knowledge in engineering modeling, mass transfer, and bioprocess optimization.\nStrong interpersonal and communication skills; ability to maintain focus and collaborate effectively during challenging development timelines.\nAnalytical and creative thinking.\nEffective troubleshooting skills.\nPreferred experience in handling large-scale (>50L, e.g., 200L/500L) upstream bioreactor processes.\nLanguage(s):\nEnglish. Mandarin is a plus.\nThe base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws.\nOther Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles.\nBenefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.\nPay Range (Base Pay):\n$127,313—$167,099 USD\nPlease note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.\nWork Authorization & Employment Eligibility\nApplicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.\nEEO Statement\nIt is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.\nEmployment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.\nFor information related to our privacy notice, please review: Legend Biotech Privacy 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