{"id":1016275,"url":"https://alion.io/job/lexeo-therapeutics-scientist-ii-analytical-development","title":"Scientist II, Analytical Development","company":{"id":679873,"name":"Lexeo Therapeutics","domain":"lexeotx.com","url":"https://alion.io/company/lexeotx","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Lever","truth_index":{"grade":"A","score":87,"open_postings":3,"ghost_share":0,"stale_share":0.333,"repost_share":0,"time_to_fill_p50_days":85,"computed_at":"2026-11-01T06:10:25Z"}},"role":"Biotech","role_family":"Biotech","seniority":"middle","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["New York, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":99680,"max":138500,"currency":"USD","period":"year","gross":null,"usd_annual":138500},"salary_estimate":null,"experience_years_min":6,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Benchling","optional":false},{"name":"Cell Culture","optional":false},{"name":"GMP","optional":false},{"name":"qPCR","optional":false}],"status":"live","first_seen_at":"2026-09-15T16:38:23Z","employer_posted_date":"2026-09-15","last_verified_at":"2026-11-01T19:33:55Z","board_verified":true,"closed_at":null,"days_open":47,"trust":{"level":"ok","repost_count":1,"flags":[],"days_open":46},"description":"Role Summary\nThis Scientist II will independently design, execute, and analyze research studies and will drive one or more analytical development projects for AAV-based gene therapy programs. The role provides technical leadership in the development, optimization, qualification, validation, and transfer of analytical assays, including cell-based potency and molecular methods such as qPCR and ddPCR. The Scientist II will apply broad scientific knowledge and novel approaches to establish AAV mechanisms of action in cellular systems, resolve moderately complex technical issues, and support GMP manufacturing, material release, and regulatory submissions in collaboration with groups across CMC, Quality, QC, and external partners.\nThe ideal candidate is highly collaborative, detail-oriented, able to manage multiple priorities, and effective in a fast-paced environment. The Scientist II is expected to exercise sound scientific judgment, communicate complex technical issues clearly, build alignment across functions, and serve as a technical resource to colleagues. This is a highly visible and impactful role in our CMC organization.\nPrimary Responsibilities\nIndependently design and optimize analytical methods involving in-vitro cell culture and AAV transduction to demonstrate potency of the gene therapy vectors\nAssist in the timely development and internal testing of CQAs, including potency assays, in a target-specific manner\nGenerate high-quality, reproducible data to support assay qualification, validation, method transfer, and QC-related activities for GMP material release\nAnalyze, interpret, summarize, and communicate findings through technical reports and presentations that clearly describe the scientific problem, relevant literature, experimental procedures, observations, and conclusions \nAssist in driving analytical strategy and support regulatory submissions in collaboration with internal groups across CMC, Quality, and CROs\nIdentify technical risks related to assay performance, evaluate relevant factors, and develop mitigation strategies, novel processes, or alternative approaches to solve problems and support continuous improvement\nCollaborate on and review technical documentation and protocols to support late-phase assay validation projects at respective CDMO/CROs\nMaintain accurate laboratory records and ensure compliance with company policies and regulatory standards\nApply industry best practices, regulatory expectations, and quality standards related to analytical development for gene therapy products, exercising judgment within generally defined practices and policies when selecting methods and techniques\nApply results and learnings from previous studies, and assimilate knowledge or techniques from adjacent scientific fields, to address new or different problems and achieve project goals\nCollaborate and build constructive relationships across departments; serve as a technical resource and provide scientific coaching and technical guidance within project teams\nRequired Skills and Qualifications\nBS in Biology, Chemistry, Biochemistry, Biotechnology, Pharmaceutical Sciences, Chemical Engineering, or a related scientific discipline with 6-8 years of relevant experience (MS with 4-6 years or PhD with 1-3 years of relevant industry experience)\nExperience in cell and gene therapy products\nStrong hands-on experience with tissue culture, analytical assay development and execution, data analysis, and troubleshooting\nExperience with pharmaceutical drug-process validation and manufacture a plus\nKnowledge of FDA, cGMP, and ICH guidelines and QBD principles a plus\nStrong organizational skills, attention to detail, and data accuracy\nExcellent communication, collaboration, and problem-solving skills with the ability to work effectively across functional teams\nCross functional acumen and highly skilled in working with complex issues and creating direction in shifting priorities and ambiguity. Results oriented with breadth and depth in pharmaceutical development and commercial products to resolve complex problems\nResults-oriented, with strong initiative, accountability, and willingness to take ownership of projects, deliver milestones, and drive work to completion\nFamiliarity with electronic laboratory notebook and inventory systems such as Benchling or Quartzy preferred","description_format":"text","description_chars":4338,"description_truncated":false,"requirements":{"experience_years_min":6,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Rare Disease Therapeutics"],"lifecycle":[{"event":"open","at":"2026-09-17T23:25:00Z"},{"event":"close","at":"2026-10-02T07:41:23Z"},{"event":"reopen","at":"2026-10-26T20:25:56Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 1","filings_12m":1,"filings_prev_12m":1,"green_card_filings_12m":0,"median_offered_wage_usd":182500,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":75,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.83,"p_room":0.9,"age_days":46,"expected_fill_days":85,"reasons":["conf:2","win:mid"],"computed_at":"2026-11-01T06:10:25Z"},"pay":{"stated_usd_annual":138500,"is_top_pay":true},"html_url":"https://alion.io/job/lexeo-therapeutics-scientist-ii-analytical-development","json_url":"https://alion.io/job/lexeo-therapeutics-scientist-ii-analytical-development.json","meta":{"generated_at":"2026-11-01T22:27:53Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":34292,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-02T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":679873},"rest":"https://alion.io/mcp/rest/get_company?id=679873"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Flexeo-therapeutics-scientist-ii-analytical-development"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Flexeo-therapeutics-scientist-ii-analytical-development"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Flexeo-therapeutics-scientist-ii-analytical-development"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/lexeo-therapeutics-scientist-ii-analytical-development\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Flexeo-therapeutics-scientist-ii-analytical-development"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":1016275}},{"tool":"search_jobs","arguments":{"company":"lexeotx.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":1016275},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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