{"id":529312,"url":"https://alion.io/job/lgc-group-principal-chemist","title":"Principal Chemist","company":{"id":4750,"name":"LGC Group","domain":"lgcgroup.com","url":"https://alion.io/company/lgc-group","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"SmartRecruiters","truth_index":{"grade":"B","score":75,"open_postings":10,"ghost_share":0,"stale_share":1,"repost_share":0,"time_to_fill_p50_days":33,"computed_at":"2026-10-24T06:02:35Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"lead","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Petaluma, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":131155,"max":196733,"currency":"USD","period":"year","gross":null,"usd_annual":196733},"salary_estimate":null,"experience_years_min":15,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"HPLC","optional":false},{"name":"Mass Spectrometry","optional":false}],"status":"live","first_seen_at":"2026-07-01T13:15:15Z","employer_posted_date":"2026-07-01","last_verified_at":"2026-10-24T05:52:16Z","board_verified":true,"closed_at":null,"days_open":114,"trust":{"level":"stale","repost_count":0,"flags":["stale"],"days_open":114},"description":"ABOUT LGC BIOSEARCH TECHNOLOGIES:\nWith manufacturing sites across the US, UK, Germany and Denmark, LGC Biosearch Technologies has plans to continue growing. We deliver mission critical genomics to our diverse customer base in molecular diagnostics, pharma/biotech and agrigenomics. Our integrated portfolio of products, services and expertise supports our purpose of Science for a Safer World and we have embodied our mission by working with customers to enable research into life-altering treatment for disease and illness worldwide. We are currently seeking candidates who are up for the challenge of operating in a high-growth, purpose-driven organisation.\n Principal Oligonucleotide Chemist\nCompany: LGC Biosearch Technologies\nLocation: 2100 South McDowell, Petaluma, CA 94952\nType: Full-time\nCompany Overview\nLGC Biosearch Technologies operates across manufacturing sites in the US, UK, Germany, and Denmark, providing mission-critical genomics solutions to customers in molecular diagnostics, pharma/biotech, and agrigenomics. Our integrated portfolio of products, services, and expertise supports our mission of Science for a Safer World. We partner closely with customers to enable research and development of life-altering treatments for diseases worldwide. Join our high-growth, purpose-driven organization.\nPosition Summary\nThe Principal Oligonucleotide Chemist is a senior scientific leader responsible for driving oligonucleotide product development, synthesis, process development, and innovation across the Innovation Hub, operations, and customer-facing programs. This role blends hands-on laboratory execution with strategic experimental design, data-driven development, project leadership, and mentorship of scientists to deliver new products.\nYou will serve as the technical lead for Oligonucleotide New Product Development (NPD), and Customer co-creation product projects, designing new manufacturing methods, troubleshooting complex issues, supporting tech transfer, and presenting technical content to commercial teams and customers. This position plays a critical role in advancing LGC’s oligonucleotide chemistry capabilities and new product offerings.\nKey Responsibilities\nLeadership in Oligonucleotide Chemistry, Project Execution and Delivery\nLead Petaluma Innovation Hub Oligo Chemistry Function by delivering customer co-creation and NPD products/projects from concept through delivery. \nPartner with peers and global team to deliver to customers and achieve Innovation Hub development and financial objectives.\nServe as a technical lead for multi-site, multi-function development team for oligonucleotide synthesis, modification, deprotection, purification, and analytical characterization.\nParticipate in evaluation of new technologies and oligonucleotide market strategy\nOversee and Execute oligo synthesis projects, including experimental design/planning, prioritization, and resource coordination.\nDeliver and control new methods, workflows, and manufacturing protocols for oligonucleotide synthesis, purification and analysis. Support operations technically.\nOptimize, and define manufacturing instructions for low-yielding or impure processes.\nLaboratory Execution & Product Manufacturing\nLead projects and staff hands-on in the lab by performing and training synthesis and purification of oligonucleotides using automated and manual techniques.\nConduct analytical characterization (LC-MS, HPLC, CE, UV-Vis) to confirm identity, purity, and impurity profiles.\nTroubleshoot synthetic routes, instrument performance, and purification workflows and analytics to ensure consistent, high-quality output.\nDevelop and refine synthetic routes, synthesis method refinement, coupling conditions, deprotection strategies and purification methods.\nExperimental Design, Data Analysis & Development Strategy\nDesign rigorous, data-driven experiments to optimize yield, purity, scalability (up and down), and process robustness.\nUse mechanistic understanding and statistical analysis to adjust development plans and guide next-step decision-making.\nLead troubleshooting efforts by designing investigation maps and structured experimental plans.\nDocument experimental results, conclusions, and recommendations by industry standard technical summary reports and within quality certification requirements.\nCustomer Co-Creation & Technical Communication\nSuccessfully lead and deliver oligonucleotide customer co-creation and NPD projects.\nParticipate in technical customer calls related to custom oligo manufacturing, product investigations, and development updates.\nPresent technical content to commercial teams and customers, including data reviews, capability overviews, and project progress.\nOperations Support, Tech Transfer & Continuous Improvement\nProvide technical support to Operations for process optimization, scale-up, and continual improvement.\nLead the successful transfer of custom product methods and procedures into MSAT and Operations teams.Develop effective tech transfer plans and verify training for newly developed processes.\nDeliver method validation in alignment with Quality department requirements.\n\nSupport troubleshooting and root-cause investigations for manufacturing challenges.\nMentorship & Team Development\nMentor and develop scientists in oligonucleotide chemistry; providing guidance in technical skills, experimental design, and professional development.\nPromote rigorous laboratory order and management, controlled documentation, and best practices in experimental execution.\nFoster a collaborative, trust building and growth-oriented environment that supports scientific excellence.\nTechnical Skills\nProven expertise in oligonucleotide chemistry.\nDemonstrated knowledge of solid-phase oligonucleotide synthesis and modification.\nSkilled in analytical characterization of oligonucleotides, including impurity profiling.\nDemonstrated project management skills with experience leading matrixed teams through complex development projects.\nSeasoned ability to design, optimize, and troubleshoot oligonucleotide manufacturing development processes\n Qualifications\nPh.D. in Synthetic Organic Chemistry, Chemical Biology, or related field inclusive of extensive experience in oligonucleotide chemistry.\nMinimum of 15 years of direct industry experience in oligonucleotide synthesis, product and process development, and tech transfer into manufacturing.\nDemonstrated ability to lead technical projects, mentor scientists, and collaborate cross-functionally.\nExcellent communication skills, including the ability to present complex technical content to internal and external audiences.\n The typical pay range for this role is:\nMinimum: $ 131,155/ Annualy\nMaximum: $196,733/ Anually\nThis range represents the low and high end of the anticipated salary range for the California -based position. The actual base salary will depend on several factors such as: experience, skills, and location.\nABOUT LGC:\nLGC is a leading, global life science tools company, providing mission-critical components and solutions into high-growth application areas across the human healthcare and applied market segments. Its high-quality product portfolio is comprised of mission-critical tools for genomic analysis and for quality assurance applications, which are typically embedded and recurring within our customers’ products and workflows and are valued for their performance, quality, and range.\nOUR VALUES\nPASSION\nCURIOSITY\nINTEGRITY\nBRILLIANCE\nRESPECT\nEQUAL OPPORTUNITIES\nLGC strongly believes that every job applicant and employee should be valued for their individual talents regardless of age, disability, race, color, ethnic or national origin, sex, sexual orientation, gender reassignment, marital or civil partnership, pregnancy or maternity, religion, or belief. Short listing, interviewing and selection will always be carried out without regard to gender, sexual orientation, marital status, color, race, nationality, ethnic or national origins, religion or belief, age, or trade union membership.\nFor more information about LGC, please visit our website www.lgcgroup.com\n#scienceforasaferworld","description_format":"text","description_chars":8133,"description_truncated":false,"requirements":{"experience_years_min":15,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[{"language":"English","level":"All levels","optional":false}]},"benefits":["Professional development"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Molecular Diagnostics","Laboratory Equipment","Testing, Inspection & Certification"],"lifecycle":[{"event":"open","at":"2026-09-08T06:18:21Z"}],"visa":[],"liveness":{"score":11,"band":"cold","label":"Long shot","p_open":1,"p_active":0.384,"p_room":0.28,"age_days":114,"expected_fill_days":33,"reasons":["conf:0","stale_co","win:tail","crowd:"],"computed_at":"2026-10-24T06:02:35Z"},"pay":{"stated_usd_annual":196733,"is_top_pay":true},"html_url":"https://alion.io/job/lgc-group-principal-chemist","json_url":"https://alion.io/job/lgc-group-principal-chemist.json","meta":{"generated_at":"2026-10-24T07:44:10Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":11374,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-25T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":4750},"rest":"https://alion.io/mcp/rest/get_company?id=4750"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Flgc-group-principal-chemist"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Flgc-group-principal-chemist"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Flgc-group-principal-chemist"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/lgc-group-principal-chemist\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Flgc-group-principal-chemist"}]}