{"id":1261055,"url":"https://alion.io/job/manifold-bio-scientist-cdna-display","title":"Scientist, cDNA Display","company":{"id":1883364,"name":"Manifold Bio","domain":"manifold.bio","url":"https://alion.io/company/manifold-bio","size_band":"11-50","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"B","score":75,"open_postings":5,"ghost_share":0,"stale_share":1,"repost_share":0,"time_to_fill_p50_days":null,"computed_at":"2026-10-15T05:46:00Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":null,"employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Boston, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":118000,"max":138000,"currency":"USD","period":"year","gross":null,"usd_annual":138000},"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[],"status":"live","first_seen_at":"2026-03-04T18:47:57Z","employer_posted_date":"2026-08-11","last_verified_at":"2026-10-15T08:20:41Z","board_verified":true,"closed_at":null,"days_open":224,"trust":{"level":"stale","repost_count":0,"flags":["stale"],"days_open":224},"description":"Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.\nPosition\nManifold Bio is seeking a scientist to build and own a high-throughput, automated cell-free display platform for screening computationally designed protein binder libraries against hundreds of therapeutic receptor targets. This platform will be a cornerstone of Manifold's closed-loop AI-driven molecule discovery engine, generating the large-scale, high-quality binding data needed to train and improve our design models. The ideal candidate is a hands-on scientist with deep expertise in cell-free display technologies and a drive to build automated systems that can operate at scale. You will work at the intersection of protein engineering, laboratory automation, and ML-guided drug discovery, collaborating closely with our binder discovery, ML, and automation teams.\nResponsibilities\nDesign, develop, and validate a cell-free display platform (cDNA display or similar) compatible with diverse binder formats \nWork with automation team to scale and automate the platform to enable routine, high-throughput screening against large panels of therapeutic targets\nCollaborate with ML and computational teams to ensure screening outputs feed effectively into model training pipelines\nWork with the protein engineering team to support discovery campaigns and affinity maturation as platform capacity allows \nStay current on advances in cell-free display, laboratory automation, and computational protein design\nRequired Qualifications\nPhD or equivalent experience in protein biochemistry, molecular biology, biological engineering, or a related field\nHands-on experience with cell-free selection systems (cDNA display, mRNA display, ribosome display, or similar)\nStrong molecular biology fundamentals and demonstrated ability to develop and troubleshoot complex, multi-step workflows\nExperience with or strong interest in laboratory automation\nPreferred Qualifications\nTrack record of successfully automating complex laboratory workflows\nBackground in therapeutic antibody discovery or protein engineering \nExperience with computational protein design\nFamiliarity with how high-throughput screening data feeds into ML and computational pipelines\nExperience with complex or non-traditional binder formats and biochemical intuition to adapt selection workflows accordingly\nWhy you might be a good fit\nBuilding systems that generate data at a scale previously impossible excites you\nYou thrive in fast-moving environments where you own a problem end-to-end\nYou are energized by working at the intersection of wet lab science, automation, and AI-driven biotherapeutic discovery\nYou are a collaborative scientist who communicates well across teams with different technical backgrounds\nBase Salary Range: $118,000-138,000\nThis reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.\nThis role is eligible for:\nAnnual performance-based target bonus\nStock options\nComprehensive medical, dental, and vision coverage\n401(k) plan\nFlexible paid time off and holidays\nPerks including on-site gym, onsite lunch, and commuter support\nOur compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.\nWe value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.","description_format":"text","description_chars":4240,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity","Stock options"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Drug Discovery"],"lifecycle":[{"event":"open","at":"2026-09-25T20:34:59Z"}],"visa":[],"liveness":{"score":7,"band":"cold","label":"Long shot","p_open":1,"p_active":0.244,"p_room":0.28,"age_days":224,"expected_fill_days":66,"reasons":["conf:1","win:tail","crowd:"],"computed_at":"2026-10-15T05:46:00Z"},"pay":{"stated_usd_annual":138000,"is_top_pay":true},"html_url":"https://alion.io/job/manifold-bio-scientist-cdna-display","json_url":"https://alion.io/job/manifold-bio-scientist-cdna-display.json","meta":{"generated_at":"2026-10-15T10:04:48Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":15209,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-16T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":1883364},"rest":"https://alion.io/mcp/rest/get_company?id=1883364"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fmanifold-bio-scientist-cdna-display"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fmanifold-bio-scientist-cdna-display"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fmanifold-bio-scientist-cdna-display"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/manifold-bio-scientist-cdna-display\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fmanifold-bio-scientist-cdna-display"}]}