{"id":1292150,"url":"https://alion.io/job/maze-therapeutics-manager-chemical-development","title":"Manager, Chemical Development","company":{"id":1989724,"name":"Maze Therapeutics","domain":"mazetx.com","url":"https://alion.io/company/mazetx","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":null},"role":"Public Policy","role_family":"Public Policy","seniority":null,"employment_type":null,"work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["South San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":158000,"max":193000,"currency":"USD","period":"year","gross":null,"usd_annual":193000},"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[],"status":"live","first_seen_at":"2026-08-28T17:20:54Z","employer_posted_date":"2026-08-28","last_verified_at":"2026-10-20T22:12:31Z","board_verified":true,"closed_at":null,"days_open":53,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":53},"description":"The Position\nMaze's Chemical Development team manages the manufacture of drug substance (DS) for Maze's clinical programs. The team develops, optimizes, and scales chemical manufacturing processes so that reactions run safely, effectively, and economically from bench to clinic. \nAs Manager, Chemical Development, you will manage external contract manufacturing organizations (CMOs) that manufacture and test drug substance and starting materials (SM). You will work closely with Maze's discovery teams, for example medicinal chemistry, drug metabolism and pharmacokinetics (DMPK), and pharmacology, to carry candidates smoothly from preclinical work into manufacturing. You will also partner with Quality Assurance and Regulatory Affairs to keep Maze's manufacturing compliant with current good manufacturing practices (cGMPs) and federal regulations. \nThis is a role for someone who wants direct ownership of how a molecule becomes a manufacturable drug substance, with visibility across discovery, quality, and regulatory functions at a clinical-stage company. \nThe Impact You’ll Have\nDirect international CMOs developing new chemical processes, designing experiments to improve process efficiency, and troubleshooting manufacturing issues. \nAnalyze existing production methods and recommend improvements that support Maze's clinical timelines. \nPartner with Quality Assurance and Regulatory Affairs to ensure manufacturing stays compliant and audit-ready. \nPrepare technical reports and present results to internal teams and external partners. \nTrack industry trends and advancements in chemical technology that could improve Maze's processes. \nBecause this role works closely with international CMOs, meetings outside standard business hours may be required to accommodate global time zones. Domestic and international travel will also be required based on program and CMO needs. \nWhat We’re Looking For\nM.S. or Ph.D. in synthetic organic chemistry, with postgraduate experience in process chemistry and/or cGMP chemical manufacturing, gained internally or at an external CMO: 2 to 3 or more years for a Ph.D., or 5 or more years for an M.S. \nWorking knowledge of chemical reaction mechanisms and kinetics. \nExperience with process optimization and scale-up. \nFamiliarity with cGMP regulatory compliance in chemical manufacturing. \nExperience preparing technical reports and presenting findings to technical and cross-functional audiences. \nProficiency with standard chemistry software such as ChemDraw and SciFinder. \nAbility to manage multiple projects and deadlines concurrently. \nAvailability to travel domestically and internationally. \nPreferred Qualifications\nExperience working directly with external CMOs on technology transfer or scale-up. \nBackground in environmental health and safety practices in a laboratory or manufacturing setting\nThis role follows a hybrid schedule, with an expectation to be onsite at our South San Francisco headquarters at least three days per week. \n\nAbout Maze Therapeutics\nMaze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1-mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.\nOur People\nMaze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. \nOur Core Values\nFurther Together - Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission. \nImpact Obsessed - We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.\nStand True - Our integrity is foundational; it guides us no matter the obstacle.\nThe expected annual salary range for employees located in the San Francisco Bay Area is $158,000 - $193,000. Additionally, this position is eligible for an annual performance bonus.\nMaze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.\nMaze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.\n#LI-Hybrid","description_format":"text","description_chars":5326,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity","Vision insurance"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Precision Medicine","Drug Discovery","Rare Disease Therapeutics"],"lifecycle":[{"event":"open","at":"2026-09-26T08:07:59Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 4 · green card filings: 1","filings_12m":4,"filings_prev_12m":3,"green_card_filings_12m":1,"median_offered_wage_usd":127500,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":15,"band":"cold","label":"Long shot","p_open":1,"p_active":0.418,"p_room":0.35,"age_days":52,"expected_fill_days":23,"reasons":["conf:0","win:tail"],"computed_at":"2026-10-20T05:45:00Z"},"pay":{"stated_usd_annual":193000,"is_top_pay":true},"html_url":"https://alion.io/job/maze-therapeutics-manager-chemical-development","json_url":"https://alion.io/job/maze-therapeutics-manager-chemical-development.json","meta":{"generated_at":"2026-10-21T02:00:05Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":3031,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-22T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":1989724},"rest":"https://alion.io/mcp/rest/get_company?id=1989724"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fmaze-therapeutics-manager-chemical-development"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fmaze-therapeutics-manager-chemical-development"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fmaze-therapeutics-manager-chemical-development"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/maze-therapeutics-manager-chemical-development\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fmaze-therapeutics-manager-chemical-development"}]}