{"id":1310734,"url":"https://alion.io/job/mbxbio-director-bioanalytical","title":"Director, Bioanalytical","company":{"id":2359299,"name":"mbxbio","domain":"mbxbio.com","url":"https://alion.io/company/mbxbio","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":null},"role":"Early Careers","role_family":"Early Careers","seniority":"head","employment_type":null,"work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Burlington, United States","Burlington, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":83000,"max_usd":246000,"period":"year","method":"role_seniority_country_remote_cell","sample_n":330},"experience_years_min":9,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-08-17T20:06:18Z","employer_posted_date":"2026-08-17","last_verified_at":"2026-10-19T14:14:13Z","board_verified":true,"closed_at":null,"days_open":62,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":62},"description":"Working with Us\nMBX Biosciences is a clinical-stage biopharmaceutical company headquartered in Carmel, Indiana, with a secondary office in Burlington, MA. Our mission is to transform the lives of people impacted by endocrine and metabolic disorders through our novel precision peptides.\nLeveraging our proprietary Precision Endocrine Peptides (PEPs)™ platform, we are pioneering technology designed to overcome key limitations of existing therapies and enhance efficacy, tolerability, safety and convenience. Our team is advancing a pipeline of novel candidates with clinically validated targets, established endpoints for regulatory approval, and strong market potential.\nOur pipeline includes canvuparatide (MBX 2109) for the treatment of chronic hypoparathyroidism, currently preparing for Phase 3 development, and a growing obesity portfolio that includes MBX 4291 in Phase 1 development, MBX 5765, a next-generation amycretin prodrug designed for once-monthly-dosing, as well as MBX 6180, a GLP/GIP/GCGR triple agonist prodrug for once monthly dosing; all of which optimize our PEP platform.\nIf you’re passionate about advancing innovative treatments for patients and shaping the future of precision peptide therapeutics, this is your chance to make a real impact alongside a fast-paced, growing, mission-driven team. To learn more, visit our website mbxbio.com and follow us on LinkedIn.\nWhat You’ll Do\nThe Director of Bioanalytical Sciences at MBX Biosciences is expected to provide strategic, scientific, and operational leadership for the development, validation, and execution of bioanalytical strategies that support the company's portfolio of precision peptide therapeutics across discovery, preclinical, and clinical development stages. This role is responsible for ensuring the generation of high-quality pharmacokinetic (PK), anti-drug antibody (ADA), immunogenicity, pharmacodynamic (PD), and biomarker data to advance MBX's innovative endocrine and metabolic disease programs and meet global regulatory requirements. The Director partners closely with Research, Clinical Development, Clinical Pharmacology, Regulatory Affairs, CMC, Quality, and external CRO partners to drive efficient program execution and data integrity. The ideal candidate combines deep expertise in large molecule and peptide bioanalysis with strong leadership, vendor management, and cross-functional collaboration skills, enabling the successful progression of candidates from IND-enabling studies through pivotal clinical development. Key responsibilities include:\nProvide strategic leadership for bioanalytical assay development, validation, transfer, and execution to support discovery, preclinical, and clinical-stage peptide therapeutic programs.\nLead bioanalytical activities for pharmacokinetic (PK), pharmacodynamic (PD), immunogenicity (ADA/NAb), and biomarker assessments across MBX's endocrine and metabolic disease portfolio.\nDevelop and implement phase-appropriate bioanalytical strategies that ensure compliance with FDA, EMA, ICH, and other global regulatory requirements.\nServe as the bioanalytical subject matter expert on cross-functional project teams, partnering closely with Research, Clinical Development, Clinical Pharmacology, Regulatory Affairs, CMC, and Quality functions.\nOversee external CROs and laboratory partners, ensuring high-quality data delivery, adherence to timelines, budget management, and operational excellence.\nReview, interpret, and communicate bioanalytical, PK, immunogenicity, and biomarker data to support key development, regulatory, and portfolio decision-making.\nDrive authoring and review of regulatory submissions and supporting documentation, including INDs, clinical study reports, bioanalytical reports, and responses to health authority inquiries.\nBuild, mentor, and develop high-performing bioanalytical teams while fostering a culture of scientific rigor, collaboration, innovation, and continuous improvement.\nIdentify and implement emerging bioanalytical technologies and best practices to enhance data quality, operational efficiency, and the successful advancement of MBX's precision peptide therapies.\nOther responsibilities as assigned.\nWhat You Bring\nMS with 9+ years of experience or PhD in a relevant field with 7+ years of bioanalytical experience in biotech/pharma, including leadership responsibility supporting preclinical and clinical development programs.\nDeep expertise in LC-MS/MS, biomarker assays, and immunogenicity testing for peptides and small molecules.\nProven experience in bioanalytical method development and validation.\nStrong knowledge of GLP, GCLP and bioanalytical regulatory guidance (ICH M10) and experience supporting regulatory submissions.\nExperience managing CROs and external bioanalytical laboratories, including assay transfer, validation oversight, troubleshooting and vendor governance.\nDemonstrated leadership in supporting early and late-stage clinical development programs, including Phase I-III studies and IND/BLA/NDA support.\nExperience with metabolic disease, obesity, endocrinology, and peptide therapeutics is highly desirable.\nExcellent strategic communication and data interpretation skills, including presentation to executive leadership, health authorities, and external partners.\nProven people-management and organizational leadership capability, including mentoring scientists and building scalable bioanalytical operations in a growth-stage biotech environment.\nTravel & In Office Presence \nYou will be expected to travel periodically based on the needs of the business, including attendance at Together Weeks, Together Days, and functional meetings as requested by the team. Employees are expected to work on hybrid schedules, consistent with local office practices and the terms of the companies in office policy as in effect from time to time.\nEEO Statement: \nMBX Biosciences is an Equal Opportunity Employer and is committed to treating all applicants fairly without discrimination. We welcome applications from all individuals, regardless of race, national origin, gender, age, physical characteristics, social origin, disability, union membership, religion, family status, pregnancy, sexual orientation, gender identity, gender expression or any unlawful criterion under applicable law.","description_format":"text","description_chars":6300,"description_truncated":false,"requirements":{"experience_years_min":9,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Biotechnology","Health Care","Science & Engineering","Vaccines"],"lifecycle":[{"event":"open","at":"2026-09-26T15:59:14Z"}],"visa":[],"liveness":{"score":34,"band":"fade","label":"Fading","p_open":1,"p_active":0.777,"p_room":0.44,"age_days":62,"expected_fill_days":56,"reasons":["conf:3","win:tail","crowd:"],"computed_at":"2026-10-19T05:45:15Z"},"pay":null,"html_url":"https://alion.io/job/mbxbio-director-bioanalytical","json_url":"https://alion.io/job/mbxbio-director-bioanalytical.json","meta":{"generated_at":"2026-10-19T17:16:48Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":13122,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-20T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":2359299},"rest":"https://alion.io/mcp/rest/get_company?id=2359299"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fmbxbio-director-bioanalytical"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fmbxbio-director-bioanalytical"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fmbxbio-director-bioanalytical"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/mbxbio-director-bioanalytical\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fmbxbio-director-bioanalytical"}]}