{"id":1847471,"url":"https://alion.io/job/merckgroup-internship-adc-modeling-mfd","title":"Internship - ADC modeling (m/f/d)","company":{"id":64563,"name":"Merck Group","domain":"merckgroup.com","url":"https://alion.io/company/merckgroup","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Phenom","truth_index":{"grade":"A","score":100,"open_postings":12,"ghost_share":0,"stale_share":0.167,"repost_share":0,"time_to_fill_p50_days":19,"computed_at":"2026-10-14T06:34:16Z"}},"role":"Early Careers","role_family":"Early Careers","seniority":"intern","employment_type":"internship","work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Corsier, Switzerland"],"countries":["CH"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":40000,"max_usd":78000,"period":"year","method":"global_role_cell_scaled_by_country","sample_n":621},"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Python","optional":false}],"status":"live","first_seen_at":"2026-10-04T20:08:38Z","employer_posted_date":"2026-10-04","last_verified_at":"2026-10-14T14:15:07Z","board_verified":true,"closed_at":null,"days_open":9,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":9},"description":"Work Your Magic with us!\nReady to explore, break barriers, and discover more? We know you’ve got big plans - so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.\nUnited As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.\nStart Date: 1st January 2027\nDuration: 6 months\nLocalisation: Corsier-sur-Vevey\nRole Level: Internship\nConjugation of monoclonal antibody with a drug linker is a critical step in the development of antibody-drug bioconjugates. Today, offline analytical methods provide detailed information on the reaction, but they are time-consuming and don’t enable continuous process monitoring.The objective of this project is to develop a proof of concept for a hybrid soft sensor combining UV-Vis spectroscopy to provide fast, information-rich process measurements; a kinetic reaction model to describe the evolution of the conjugation species; an Extended Kalman Filter to combine measurements and model predictions while accounting for their respective uncertainties. The internship will focus primarily on modelling and data analysis, with experimental work performed when needed to support the project.\nYour Role:\nSupport the development and evaluation of the UV-Vis-based soft sensor, including data preprocessing and chemometric data treatment.\nDevelop kinetic reaction models using gPROMS and/or Python to describe the evolution of the conjugation species.Compare different kinetic model structures, estimate kinetic parameters, and assess the predictive performance.\nValidate the kinetic model against independent experimental or offline analytical data where available.Combine kinetic model with the soft sensor data using an Extended Kalman Filter.\nEvaluate the ability of the hybrid model to update the estimated reaction state and predict the reaction progress.Identify data gaps and, if required, design and perform additional small-scale conjugation experiments.\nAnalyze model performance, robustness and limitations.\nPlan and execute experiments in collaboration with PAT, modelling and process experts.Ensure that experimental conditions and results are accurately recorded and traceable.\nDevelop Python-based tools for data preparation, visualization, and analysis.Present your results during project reviews and prepare a final technical report.\nYour Profil:\nCurrently in master’s or Engineering student in data science, analytical chemistry, biochemistry, biotechnology, chemical engineering or a related field.\nStrong interest in reaction kinetics, mechanistic modelling, dynamic systems, and data science.\nExperience with python and gPROMS or another process modelling tool is a strong plus.\nInterest in spectroscopy and chemometrics; knowledge of UV-Vis or PLS is an advantage.\nPractical laboratory experience and strong attention to data quality and reproducibility.\nKnowledge of Kalman filtering is a plus.\nCurious, rigorous, proactive, and able to work independently as well as in a\nmultidisciplinary team.\nFluent in English\nWhat we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!\nApply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!","description_format":"text","description_chars":4402,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"master","optional":false},"security_clearance":false,"languages":[{"language":"English","level":"Advanced (C1)","optional":false}]},"benefits":["Flexible schedule"],"hiring_locations":[{"name":"Switzerland","iso":"CH","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Prescription Drugs","Advanced Materials","Laboratory Equipment","Chemical Manufacturing"],"lifecycle":[{"event":"open","at":"2026-10-04T20:08:38Z"},{"event":"close","at":"2026-10-06T11:22:37Z"},{"event":"reopen","at":"2026-10-06T17:20:48Z"},{"event":"close","at":"2026-10-12T11:09:41Z"},{"event":"reopen","at":"2026-10-12T11:10:53Z"},{"event":"close","at":"2026-10-13T17:19:29Z"},{"event":"reopen","at":"2026-10-13T21:25:25Z"}],"visa":[],"liveness":{"score":76,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.841,"p_room":0.9,"age_days":9,"expected_fill_days":19,"reasons":["conf:0","velocity","win:mid","comp:junior,brand"],"computed_at":"2026-10-14T06:34:16Z"},"pay":null,"html_url":"https://alion.io/job/merckgroup-internship-adc-modeling-mfd","json_url":"https://alion.io/job/merckgroup-internship-adc-modeling-mfd.json","meta":{"generated_at":"2026-10-14T14:31:02Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":17906,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-15T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":64563},"rest":"https://alion.io/mcp/rest/get_company?id=64563"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fmerckgroup-internship-adc-modeling-mfd"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fmerckgroup-internship-adc-modeling-mfd"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fmerckgroup-internship-adc-modeling-mfd"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/merckgroup-internship-adc-modeling-mfd\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fmerckgroup-internship-adc-modeling-mfd"}]}