{"id":1877166,"url":"https://alion.io/job/meridian-bioscience-scientist-upstream-process-development","title":"Scientist, Upstream Process Development","company":{"id":2303760,"name":"Meridian Bioscience","domain":"meridianbioscience.com","url":"https://alion.io/company/meridianbioscience","size_band":"201-500","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"iCIMS","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":"staff","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Memphis, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":71000,"max_usd":168000,"period":"year","method":"role_seniority_country_remote_cell","sample_n":198},"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Bioreactors","optional":false},{"name":"Cell Culture","optional":false},{"name":"ISO 13485","optional":false}],"status":"live","first_seen_at":"2026-10-04T22:40:04Z","employer_posted_date":"2026-10-04","last_verified_at":"2026-11-01T21:26:26Z","board_verified":true,"closed_at":null,"days_open":28,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":28},"description":"About Meridian\nMeridian Bioscience is a fully integrated life science company that develops, manufactures, markets and distributes a broad range of innovative diagnostic products. We are dedicated to developing and delivering better solutions that give answers with speed, accuracy and simplicity that are redefining the possibilities of life from discovery to diagnosis. We are looking for talented and passionate individuals that help drive our vision. Our innovative culture will allow interested candidates to discover and create, through collaboration, cutting edge solutions to tough problems.\nJob Summary\nThe Scientist, Upstream Process Development is a hands-on technical role within Technical Operations and Development to drive the improvement and growth of our immunological reagent offerings including recombinant proteins, native/viral antigens, monoclonal antibodies, polyclonal antibodies, blockers, and custom manufacturing. This position develops, optimizes, characterizes, and scales upstream processes used to produce viral antigens and recombinant proteins, with a primary focus on mammalian cell culture. The Scientist will translate laboratory processes into robust, reproducible, and cost-effective manufacturing workflows; troubleshoot existing processes; and support technology transfer to Production and Quality Control. Success in this role requires working independently at the bench, strong experimental design, sound scientific judgment, clear technical communication, and effective collaboration with internal teams, external partners, and custommanufacturing customers.\nKey Duties\nMajor Duties and Responsibilities:\nDesign, execute, and optimize upstream processes for virus propagation and recombinant protein expression, primarily using mammalian cell culture, from laboratory-scale vessels through rocking and stirred-tank bioreactors.\nDevelop scalable seed-train and production workflows, including cell-line and host-cell selection, culture expansion, inoculation strategy, media and feed optimization, process monitoring, harvest timing, and primary recovery. \nDevelop and optimize viral production processes by evaluating host-cell performance, multiplicity of infection, infection conditions, harvest criteria, clarification, formulation, storage, and stability. \nDevelop robust mammalian expression processes for recombinant proteins and antibodies using adherent or suspension culture; support insect-cell, yeast, hybridoma, or other expression platforms when required by the project. \nApply risk-based experimental design and appropriate statistical tools to identify and characterize critical process parameters and their effects on yield, productivity, product quality, and process reproducibility.\nDevelop and characterize workflows for maintaining cell lines, cell banks, virus seed stocks, and virus banks, including propagation, storage, stability, documentation, and traceability. \nEstablish and use fit-for-purpose in-process and characterization methods for cell growth, viability, metabolites, protein expression, viral concentration, infectious titer, identity, integrity, and stability. \nPartner with downstream and analytical scientists to define harvest and clarification conditions that protect product quality and enable efficient purification of cell-culture-derived materials. \nTroubleshoot manufacturing and product-performance issues using structured root-cause analysis; recommend and implement scientifically justified process improvements and corrective actions. \nLearn and apply protein purification techniques for the purification of cell culture-derived proteins. \nPlan and document experiments, analyze and interpret data, maintain complete technical records, and prepare concise reports and presentations for internal and external stakeholders. \nLead or support technology transfer of developed processes to Production and Quality Control, including transfer plans, readiness assessments, training, and on-floor support during initial manufacturing runs.\nAuthor and revise development protocols, technical reports, SOPs, batch records, and other controlled documents in accordance with company procedures and applicable ISO 13485 requirements. \nEvaluate new upstream technologies and potential custom-manufacturing projects; contribute technical scope, feasibility, resource, timeline, and cost estimates.\nMaintain a safe, organized, and inspection-ready laboratory, including equipment upkeep, material management, biosafety practices, and compliance with established procedures. \nPerform other duties as assigned.\nOther Duties/Physical Requirements:\nPhysical\nWork is performed primarily in a laboratory environment and may involve biological materials handled under established biosafety procedures (BSL-2 and below). \nMust be able to perform repetitive movements, including pipetting and computer work. \nMust be able to concentrate, analyze data, and solve complex technical problems throughout the workday.\nOther\nOccasional work outside normal business hours, including evenings or weekends, may be required to support time-sensitive cultures, production activities, or other business needs. \nQualifications\nMinimum Education or Equivalent Experirence Required/Preferred:\nA Bachelors, Masters, or Ph.D. from an accredited institution in a relevant scientific discipline such as Virology, Biochemistry, Molecular Biology, etc. is required. \nRequired is 10+ years of relevant research or industrial experience with a bachelors, 8+ years with a Masters, or 0-2+ years with a Ph.D. \nA demonstrated scientific track record in mammalian cell culture, virus propagation, recombinant protein expression, or upstream bioprocess development is required; experience in diagnostics, biologics, or another regulated life-science environment is preferred.\nCompetencies Required or Preferred:\nExtensive hands-on experience with mammalian cell culture to produce viruses, viral antigens, recombinant proteins, or antibodies is required. \nDemonstrated experience developing and optimizing adherent and/or suspension cell-culture processes, including culture expansion, media optimization, infection or transfection, and harvest. \nWorking knowledge of upstream process scale-up and operation of rocking and/or stirred-tank bioreactors is strongly preferred. \nAbility to design statistically sound experiments, analyze multivariable data, identify process drivers, and convert results into practical process controls and recommendations. \nExperience with relevant characterization methods, such as cell growth and viability measurements, protein-expression assays, and viral infectivity assays (for example, TCID50 or plaque assays), is preferred. \nUnderstanding of cell-bank and virus-bank lifecycle management, aseptic technique, contamination control, and biosafety practices. \nAbility to learn and perform downstream bioprocessing unit operations for the purification of cell culture-derived proteins. \nAbility to collaborate effectively across development, manufacturing, and quality functions and to train or provide technical direction to laboratory and production personnel. \nStrong organization and project-management skills, with the ability to prioritize multiple assignments and respond calmly to changing business needs. \nProficient technical writing and clear, accurate oral communication of scientific data, conclusions, risks, and recommendations.\nRequired Travel\nTravel is minimal. Travel between business units, travel to scientific meetings, or travel for commercial meetings may be required.\n*All qualified applicants will receive consideration for employment without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, or other legally protected status. 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