{"id":711140,"url":"https://alion.io/job/miraibio-senior-director-lnp-formulation-process-development","title":"Senior Director, LNP Formulation & Process Development","company":{"id":680202,"name":"Mirai Bio","domain":"miraibio.com","url":"https://alion.io/company/miraibio","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":null},"role":"Leadership","role_family":"Leadership","seniority":"head","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"explicit","locations":["Cambridge, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":213000,"max":280500,"currency":"USD","period":"year","gross":null,"usd_annual":280500},"salary_estimate":null,"experience_years_min":12,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"GMP","optional":false},{"name":"Machine Learning","optional":false}],"status":"live","first_seen_at":"2026-08-27T19:23:27Z","employer_posted_date":"2026-10-05","last_verified_at":"2026-11-01T04:58:41Z","board_verified":true,"closed_at":null,"days_open":65,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":65},"description":"COMPANY DESCRIPTION\nMirai Bio is a privately-held, Flagship-founded biotechnology company that is delivering genetic medicines from promise to performance. Mirai was built to solve one of the field’s central challenges: achieving precise, scalable delivery of diverse nucleic acid payloads to specific cells and tissues, particularly beyond the liver. By combining a large and growing proprietary in vivo biodistribution dataset, machine learning-guided lipid nanoparticle optimization, modular targeted particle design, and integrated translation and manufacturing capabilities, Mirai helps partners accelerate development, reduce technical risk, and pursue high-value programs making delivery a strategic advantage. We are seeking collaborative, relentless problem solvers that share our passion for defining the future of genetic medicines together.\nTHE ROLE\nWe are seeking an experienced Senior Director of Lipid Nanoparticle (LNP) Formulation & Process Development to lead the company's LNP formulation, process development, and small-scale production organization supporting partner and internal research and preclinical programs.\nThe Senior Director will provide scientific and operational leadership across multiple programs, establish LNP development and production strategies, and build scalable, reproducible capabilities to support a growing portfolio. This individual will lead and develop a team of scientists, serve as a senior technical interface with clients and partners, and collaborate closely with Analytical Development, Translational Biology, Project Management, and other functions.\nThe successful candidate will combine deep expertise in LNP formulation and processing with strong organizational leadership, program execution, and client-facing skills.\nKEY RESPONSIBILITIES\nLead the LNP formulation, process development, and small-scale production function supporting partner and internal programs.\nEstablish technical strategy and best practices for LNP formulation, process development, characterization, and production across multiple payloads and applications.\nProvide senior technical leadership across multiple programs, including development strategy, experimental planning, data review, risk mitigation, and technical recommendations.\nServe as a senior technical interface with clients and partners and support proposals, project scopes, presentations, and business development activities.\nOversee non-GMP production of LNP formulations for in vitro, in vivo, and preclinical studies.\nDrive technical troubleshooting, process optimization, technology transfer, and continuous improvement of LNP production for mRNA, siRNA, gene-editing components, and other nucleic acid payloads.\nEstablish workflows, documentation, and operational practices that improve quality, reproducibility, efficiency, and scalability.\nLead, mentor, and develop the LNP team while managing priorities, resources, capacity, and organizational growth.\nCollaborate cross-functionally to align LNP development and production with broader program and company objectives.\nPROFESSIONAL EXPERIENCE & QUALIFICATIONS\nRequired\nPh.D. in Pharmaceutical Sciences, Chemical Engineering, Bioengineering, Chemistry, Biochemistry, or related field with 12+ years of relevant industry experience; M.S. with 14+ years; or B.S. with 16+ years.\nExtensive hands-on experience in LNP formulation and process development.\nDeep understanding of LNP composition, formation, purification, characterization, and the relationships between process parameters and product attributes.\nDemonstrated ability to lead complex technical programs, interpret data, troubleshoot problems, and establish development strategies.\nProven experience leading and developing scientific teams and managing multiple concurrent programs and resources.\nStrong written, verbal, presentation, and client-facing communication skills.\nPreferred\nExperience in a CMO, CDMO, CRO, or other client-service organization.\nExperience developing LNPs across multiple payloads and therapeutic applications.\nExperience building or scaling LNP formulation, process development, and production capabilities.\nExperience with technology transfer or transitioning development processes toward larger-scale or GMP manufacturing.\nExperience supporting technical proposals, scopes of work, and business development activities.\nLeadership Profile\nThe ideal candidate is a hands-on scientific and organizational leader who can move between technical problem-solving, portfolio strategy, team leadership, operational planning, and client engagement. The Senior Director will be accountable for leading a high-performing LNP organization and ensuring the reliable delivery of high-quality formulations and development programs that enable partner and internal programs to advance.\nABOUT FLAGSHIP PIONEERING:\nFlagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. \nFlagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.\nAt Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.\nWe are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.\nWe recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.\nRecruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.\n#LI-TL1\n\nThe salary range for this role is $213,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Mirai Bio currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Mirai Bio's good faith estimate as of the date of publication and may be modified in the future.\nPrivacy Notice for Applicants: When you apply for a role at Mirai Bio, Inc., a Flagship Pioneering portfolio company, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact .","description_format":"text","description_chars":8420,"description_truncated":false,"requirements":{"experience_years_min":12,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[{"name":"United Kingdom","iso":"GB","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Drug Discovery","Drug Discovery AI"],"lifecycle":[{"event":"open","at":"2026-09-11T04:44:28Z"},{"event":"open","at":"2026-10-12T04:45:49Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"Filed H-1B visas in the last two years","filings_12m":0,"filings_prev_12m":4,"green_card_filings_12m":0,"median_offered_wage_usd":null,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":14,"band":"cold","label":"Long shot","p_open":1,"p_active":0.501,"p_room":0.28,"age_days":65,"expected_fill_days":30,"reasons":["conf:1","win:tail","crowd:"],"computed_at":"2026-11-01T06:10:25Z"},"pay":{"stated_usd_annual":280500,"is_top_pay":true},"html_url":"https://alion.io/job/miraibio-senior-director-lnp-formulation-process-development","json_url":"https://alion.io/job/miraibio-senior-director-lnp-formulation-process-development.json","meta":{"generated_at":"2026-11-01T07:53:50Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":12188,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-02T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":680202},"rest":"https://alion.io/mcp/rest/get_company?id=680202"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fmiraibio-senior-director-lnp-formulation-process-development"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fmiraibio-senior-director-lnp-formulation-process-development"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fmiraibio-senior-director-lnp-formulation-process-development"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/miraibio-senior-director-lnp-formulation-process-development\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fmiraibio-senior-director-lnp-formulation-process-development"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":711140}},{"tool":"search_jobs","arguments":{"company":"miraibio.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":711140},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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