{"id":1998827,"url":"https://alion.io/job/moderna-inc-principal-scientist-cmc-quantitative-sciences","title":"Principal Scientist, CMC Quantitative Sciences","company":{"id":5847,"name":"Moderna","domain":"modernatx.com","url":"https://alion.io/company/modernatx","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"B","score":81,"open_postings":17,"ghost_share":0,"stale_share":0.765,"repost_share":0,"time_to_fill_p50_days":45,"computed_at":"2026-10-17T05:46:00Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"lead","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Norwood, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":142500,"max":256500,"currency":"USD","period":"year","gross":null,"usd_annual":256500},"salary_estimate":null,"experience_years_min":12,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"Power BI","optional":false},{"name":"Python","optional":false},{"name":"SAS","optional":false},{"name":"Tableau","optional":false}],"status":"live","first_seen_at":"2026-10-07T10:15:23Z","employer_posted_date":"2026-10-07","last_verified_at":"2026-10-17T04:26:01Z","board_verified":true,"closed_at":null,"days_open":10,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":10},"description":"The Role:\nModerna is seeking an accomplished and visionary Quantitative Scientist to join our Chemistry, Manufacturing, and Controls Quantitative Sciences (CMC QS) team as a Principal Scientist based in Norwood, MA. In this role, you will be responsible for delivering advanced quantitative solutions across the product lifecycle, from regulatory filings and lifecycle management to automated monitoring of CMC data.\nYou’ll partner closely with colleagues across Process Development, Analytical Development, Quality, Manufacturing, and Digital to shape scientific strategy, guide regulatory submissions, and deploy data-driven tools that directly impact decision-making. Your deep understanding of CMC domains will enable you to identify the most effective approaches to complex technical questions and influence key business outcomes.\nThis position requires someone who thrives at the intersection of science, systems, and strategy. You should be equally comfortable setting technical vision, navigating regulatory interactions, and translating statistical thinking into practical, scalable tools. The ideal candidate is self-motivated, scientifically curious, and an exceptional communicator.\nYou will be essential in advancing Moderna’s mission, helping to expand our pipeline, accelerate global impact, and uphold our values of being Bold, Collaborative, Curious, and Relentless.\nHere’s What You’ll Do:\nStrategic & Technical Leadership\nDefine and execute statistical strategies that support Moderna’s CMC and business objectives.\n\nProvide expert statistical consultation to senior leaders and cross-functional teams; shape critical product, process, and analytical method decisions through robust data analysis.\n\nLead the design and application of complex experimental and statistical models for challenges such as stability, comparability, and lifecycle management.\n\nTranslate business needs into scalable data science solutions, including tools for real-time trending, root cause analysis, and shelf-life estimation.\n\nProject & Platform Oversight\nOversee a portfolio of high-impact projects spanning regulatory filings, lifecycle extensions, and digital tools; ensure scientific quality, timelines, and business alignment.\n\nServe as the senior statistical expert on critical programs; set standards, ensure consistency, and advise on methodology choices.\n\nLead the development and governance of analytics platforms, such as stability data monitoring, CPV dashboards & architecture, automated investigation & trending tools\n\nDrive best practices in data creation, pipelining, integration, and reproducibility across GMP and non-GMP environments.\n\nCross-Functional & Regulatory Engagement\nPartner with Analytical Development, Process Development, Quality, Manufacturing, and Digital teams to embed statistical thinking into all phases of the product lifecycle.\n\nGuide regulatory strategy for specifications, comparability, expiry, and post-approval changes.\n\nLead or support interactions with regulatory agencies, including authoring responses and presenting methodologies in formal meetings.\n\nContribute to ongoing initiatives such as seasonal variant updates and the expansion of commercial manufacturing capabilities.\n\nInnovation & Continuous Improvement\nStay at the forefront of statistical science, regulatory expectations, and biopharma technology.\n\nIdentify and adopt emerging tools, platforms, and methodologies that enhance the team’s effectiveness and agility.\n\nStreamline statistical and data science workflows to reduce time to insight, improve decision-making, and scale innovation.\n\nFoster a culture of excellence, innovation, and continuous learning.\n\nMentor team members; lead internal training and upskilling efforts to strengthen statistical thinking across the organization.\n\nHere’s What You’ll Bring to the Table:\nMinimum Qualifications\nPhD in Statistics (5+ yrs), MS (10 - 12 yrs), or BS (12 - 15 yrs) in Statistics, Biostatistics, Data Science, Applied Mathematics, Chemical Engineering, Biochemical Engineering, or a related STEM discipline.\n\nProven track record of leading and delivering complex statistical projects in a fast-paced, dynamic environment\n\nDeep expertise in statistical methods for CMC applications: stability, DOE, regression, multivariate analysis, control charts, etc.\n\nSkilled in teaching non-statisticians basic & intermediate statistical methods\n\nRobust storytelling and communication skills; comfortable translating complex concepts for non-technical stakeholders.\n\nStrong programming skills in statistical and data science languages (e.g., R, Python, JMP, SAS) and experience deploying tools or dashboards (e.g., Spotfire, Power BI, Tableau).\n\nExperience with automated process monitoring, digital data pipelines, and model governance.\n\nFamiliarity with biopharma regulatory expectations (ICH, FDA, EMA, WHO, USP) and participation in agency communications.\n\nPreferred Qualifications\nUnderstanding of manufacturing and analytical systems (e.g., LIMS, MES, OSI PI, SAP).\n\nUnderstanding of GMP quality concepts used in pharmaceutical production and development\n\nExperience in regulatory interactions and submissions, including eCTD submissions, response to health authority questions, and agency meetings\n\nExperience with phase appropriate GMP principles\n\nUnderstanding of risk analysis and risk-based decision making\n\nCompetencies\nStrategic Decision-Making: Weighs business impact, scientific rigor, and operational feasibility to drive smart, timely decisions.\n\nPrioritization & Focus: Knows what matters most. Avoids overengineering and focuses on high-value work.\n\nScientific Precision: Brings deep technical expertise and attention to detail, grounded in a genuine passion for data and discovery.\n\nExecutive Communication: Translates complexity into clarity. Communicates insights that are actionable, scalable, and aligned to business needs.\n\nAgility & Growth Mindset: Embraces new information, adapts to change, and continuously evolves approaches to meet emerging challenges.\n\nOur Working Model\nAs we build our company, we have always believed that an in-person culture is critical to our success. This role is 100% onsite, reflecting the importance of being physically present to support the work, collaborate closely with colleagues, and contribute to our site-based operations. Working onsite enables real-time collaboration, strong team connections, direct mentorship, and the hands-on partnership needed to deliver our mission.\nJoin us in shaping a world where every interaction is an opportunity to learn, contribute, and make a meaningful impact.\nModerna is a smoke-free, alcohol-free, and drug-free work environment.\nPay & Benefits\nAt Moderna, we believe that when you feel your best, you can do your best work.That’s why our benefits and well-being resources are designed to support you-at work, at home, and everywhere in between.\nCompetitive healthcare, plus voluntary benefit programs to support your unique needs\nA holistic approach to well-being, with access to fitness, mindfulness, and mental health support\nFamily planning benefits, including fertility, adoption, and surrogacy support\nGenerous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown\nSavings and investments to help you plan for the future\nLocation-specific perks and extras\nThe salary range for this role is $142,500.00 - $256,500.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An individual’s position within the salary range will be based on several factors including, but not limited to, specific competencies, relevant education, qualifications, certifications, experience, skills, performance, and business or organizational needs.\n\nThe successful candidate may be eligible for an annual discretionary bonus, other incentive compensation, or equity award, subject to company plan eligibility criteria and individual performance.\nAbout Moderna\nSince our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.\nBy living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.\nWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.\nIf you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.\nEqual Opportunities\nModerna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!\nModerna is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements.\nAccommodations\nWe’re focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best.\nModerna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at .\nExport Control Notice\nThis position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant’s ability to access export-controlled information in accordance with U.S. law. Only U.S. persons (U.S. citizens, U.S. lawful permanent residents, asylees, or refugees) are currently eligible to access such information without an export license. Candidates who do not meet these criteria may still be considered, contingent on the company’s ability to obtain any required export control license.\n\n-","description_format":"text","description_chars":11017,"description_truncated":false,"requirements":{"experience_years_min":12,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Continuous learning","Equity"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Biotechnology","Prescription Drugs","Vaccines","Infectious Disease Therapeutics"],"lifecycle":[{"event":"open","at":"2026-10-07T10:15:23Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 101 · green card filings: 27","filings_12m":101,"filings_prev_12m":150,"green_card_filings_12m":27,"median_offered_wage_usd":146797,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":63,"band":"ok","label":"Likely open","p_open":1,"p_active":0.631,"p_room":1,"age_days":9,"expected_fill_days":45,"reasons":["conf:1","stale_co","velocity","win:early","comp:brand"],"computed_at":"2026-10-17T05:46:00Z"},"pay":{"stated_usd_annual":256500,"is_top_pay":true},"html_url":"https://alion.io/job/moderna-inc-principal-scientist-cmc-quantitative-sciences","json_url":"https://alion.io/job/moderna-inc-principal-scientist-cmc-quantitative-sciences.json","meta":{"generated_at":"2026-10-18T03:05:07Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":4858,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-19T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":5847},"rest":"https://alion.io/mcp/rest/get_company?id=5847"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fmoderna-inc-principal-scientist-cmc-quantitative-sciences"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fmoderna-inc-principal-scientist-cmc-quantitative-sciences"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fmoderna-inc-principal-scientist-cmc-quantitative-sciences"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/moderna-inc-principal-scientist-cmc-quantitative-sciences\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fmoderna-inc-principal-scientist-cmc-quantitative-sciences"}]}