{"id":3319147,"url":"https://alion.io/job/moderna-manager-quantitative-systems-pharmacology","title":"Manager, Quantitative Systems Pharmacology","company":{"id":5847,"name":"Moderna","domain":"modernatx.com","url":"https://alion.io/company/modernatx","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":89,"open_postings":11,"ghost_share":0,"stale_share":0.455,"repost_share":0,"time_to_fill_p50_days":56,"computed_at":"2026-10-30T05:48:23Z"}},"role":"Biotech","role_family":"Biotech","seniority":"junior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Melbourne, Australia","Australia"],"countries":["AU"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":67000,"max_usd":172000,"period":"year","method":"global_role_cell_scaled_by_country","sample_n":183},"experience_years_min":1,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"MATLAB","optional":false},{"name":"Python","optional":false}],"status":"live","first_seen_at":"2026-10-26T00:00:00Z","employer_posted_date":"2026-10-26","last_verified_at":"2026-10-30T07:45:25Z","board_verified":true,"closed_at":null,"days_open":4,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":4},"description":"The Role\nJoining Moderna means advancing mRNA science to transform medicine. Work with exceptional global teams on a broad pipeline and build a career that makes a real difference for patients.\nYou will join Moderna’s Clinical and Quantitative Pharmacology organization in Melbourne, developing and applying mechanistic quantitative systems pharmacology models across our therapeutic portfolio and mRNA platform.\nAs an individual contributor, you will work at the intersection of disease biology, pharmacology and clinical development, integrating preclinical, clinical and literature data to strengthen translation from preclinical species to humans and inform critical program decisions.\nThis role offers the opportunity to combine QSP, PK/PD, PBPK and other model-informed approaches with emerging digital and Generative AI-enabled tools to accelerate quantitative insight, scientific learning and drug development.\nHere’s What You Will Do\nDevelop and apply quantitative systems pharmacology (QSP) models that integrate biological, pharmacological and clinical knowledge to address key drug development questions across Moderna’s portfolio.\nDevelop mechanistic PK/PD, physiologically based pharmacokinetic (PBPK) and translational models to characterize drug disposition, pharmacological activity, and relationships among dose, exposure, biomarkers and clinical response.\nApply quantitative modeling and simulation to support candidate selection, preclinical-to-clinical translation, first-in-human dose selection, dose escalation and dose-regimen optimization.\nIntegrate diverse data sources, including in vitro, in vivo, clinical and literature data, to develop and validate mechanistic models and generate testable hypotheses.\nPerform model calibration, parameter estimation, sensitivity analysis, uncertainty analysis and simulation to characterize key drivers of pharmacological response and inform decision-making.\nCollaborate closely with scientists and project teams across Pharmacology, Toxicology, Translational Medicine, Research, Clinical Development and other cross-functional disciplines to identify opportunities where quantitative modeling can have meaningful program impact.\nProvide quantitative and mechanistic interpretation of experimental and clinical data to improve understanding of mechanism of action, disease biology, pharmacological activity and sources of variability in response.\nCommunicate modeling strategies, assumptions, results and recommendations to multidisciplinary project teams and scientific leadership.\nContribute quantitative modeling analyses and scientific rationale to regulatory documents and interactions, as appropriate.\nMaintain awareness of advances in QSP, systems biology, pharmacometrics, computational biology and related quantitative disciplines, incorporating relevant methodologies into drug development programs.\nExplore opportunities to apply Generative AI and other advanced digital tools to scientific literature synthesis, knowledge integration, model-development workflows and data interrogation, while maintaining appropriate scientific rigor and validation.\nOperate effectively as a highly collaborative individual contributor in a fast-paced scientific environment, bringing strong quantitative modeling capability and scientific curiosity to complex drug development questions.\nThe key Moderna Mindsets you’ll need to succeed in the role:\n“We obsess over learning. We don’t have to be the smartest we have to learn the fastest.”\n“We act with dynamic range, driving strategy and execution at the same time at every step.”\nHere is What You Will Need (Basic Qualifications)\nPhD in pharmaceutical sciences, biomedical engineering, chemical engineering, systems biology, computational biology, applied mathematics, or related quantitative discipline.\nExperience of developing and applying mechanistic mathematical models to biological or pharmacological systems.\n1-4+ years of experience in quantitative pharmacology, including QSP, PK/PD, PBPK, or other mechanistic modeling or differential equation-based mechanistic modeling approaches supporting drug discovery and development.\nStrong knowledge of pharmacology, pharmacokinetics, drug development, and quantitative analysis.\nExperience integrating and analyzing preclinical and/or clinical pharmacology data to support model development and simulation.\nProficiency with quantitative modeling and scientific computing software such as MATLAB/SimBiology, R, Python, or similar platforms.\nAbility to independently formulate biological and pharmacological questions into quantitative modeling strategies.\nStrong scientific communication skills, including the ability to clearly communicate complex modeling concepts and results to both quantitative and non-quantitative audiences.\nDemonstrated ability to collaborate effectively in multidisciplinary and cross-functional teams.\nOur Working Model\nAs we build our company, we have always believed an in-person culture is critical to our success.\nModerna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute, and make a meaningful impact.\nModerna is a smoke-free, alcohol-free, and drug-free work environment.\nPay & Benefits\nAt Moderna, we believe that when you feel your best, you can do your best work.That’s why our benefits and well-being resources are designed to support you-at work, at home, and everywhere in between.\nCompetitive healthcare, plus voluntary benefit programs to support your unique needs\nA holistic approach to well-being with access to fitness, mindfulness, and mental health support\nFamily building benefits, including fertility, adoption, and surrogacy support\nGenerous paid time off, including vacation, bank holidays, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown\nSavings and investments to help you plan for the future\nLocation-specific perks and extras\nThe benefits offered may vary depending on the nature of your employment with Moderna and the country where you work.\nAbout Moderna\nSince our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.\nBy living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.\nWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.\nIf you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.\nModerna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!\nModerna is committed to equal opportunity in employment and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. We consider qualified applicants regardless of criminal histories, consistent with legal requirements.\nWe’re focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best.\nModerna is committed to offering reasonable accommodation or adjustments to qualified job applicants with disabilities. Any applicant requiring an accommodation or adjustment in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations and Adjustments team at .\n-","description_format":"text","description_chars":8577,"description_truncated":false,"requirements":{"experience_years_min":1,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Prescription Drugs","Vaccines","Infectious Disease Therapeutics"],"lifecycle":[{"event":"open","at":"2026-10-27T06:50:11Z"}],"visa":[],"liveness":{"score":90,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.903,"p_room":1,"age_days":4,"expected_fill_days":56,"reasons":["conf:3","velocity","win:early","comp:junior,brand"],"computed_at":"2026-10-30T05:48:23Z"},"pay":null,"html_url":"https://alion.io/job/moderna-manager-quantitative-systems-pharmacology","json_url":"https://alion.io/job/moderna-manager-quantitative-systems-pharmacology.json","meta":{"generated_at":"2026-10-30T09:17:52Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":13353,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-31T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":5847},"rest":"https://alion.io/mcp/rest/get_company?id=5847"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fmoderna-manager-quantitative-systems-pharmacology"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fmoderna-manager-quantitative-systems-pharmacology"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fmoderna-manager-quantitative-systems-pharmacology"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/moderna-manager-quantitative-systems-pharmacology\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fmoderna-manager-quantitative-systems-pharmacology"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3319147}},{"tool":"search_jobs","arguments":{"company":"modernatx.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3319147},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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