{"id":3698264,"url":"https://alion.io/job/mountsinainyc-postdoctoral-fellow-msh-30001-321","title":"Postdoctoral Fellow-MSH-30001-321","company":{"id":64028,"name":"Mount Sinai Health System","domain":"mountsinai.org","url":"https://alion.io/company/mountsinainyc","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Oracle","truth_index":{"grade":"A","score":89,"open_postings":425,"ghost_share":0,"stale_share":0.452,"repost_share":0,"time_to_fill_p50_days":45,"computed_at":"2026-11-12T10:38:37Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"lead","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["New York, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Python","optional":true}],"status":"live","first_seen_at":"2025-02-14T22:08:27Z","employer_posted_date":"2025-02-14","last_verified_at":"2026-11-13T04:11:15Z","board_verified":true,"closed_at":null,"days_open":636,"trust":{"level":"stale","repost_count":0,"flags":["stale"],"days_open":635},"description":"Postdoctoral Research Scientist Position\nDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai\nAre you passionate about unraveling the mysteries of proteins and their roles in diseases like Alzheimer’s and cancer? Dr. Wei Wang ’s lab at the Icahn School of Medicine at Mount Sinai is seeking motivated Postdoctoral Research Scientists to dive into groundbreaking structural biology research. Gain hands-on experience with cutting-edge techniques like cryo-EM and X-ray crystallography in a collaborative environment. This is an incredible opportunity for recent graduates to enhance their skills and contribute to high-impact projects.\nReady to make a difference? Apply now and be a part of our team!\n Position Summary:\nAs a Postdoctoral Research Scientist, you will contribute to the investigation of the structure and dynamics of disease-related proteins using single-particle cryo-EM, X-ray diffraction, and molecular simulations. You will also participate in structure-assisted drug design in collaboration with computational scientists. This role offers the opportunity to join a multidisciplinary team dedicated to advancing time-resolved structural biology techniques to understand and manipulate the structure, function, and dynamics of drug targets.\nKey Responsibilities:\nEmploy structural biology techniques to study and understand the structure, function, and dynamics of disease-related proteins and protein-ligand complexes.\nContribute to structure-assisted drug design.\nPerform molecular dynamics simulations and QM/MM calculations.\nPublish research findings in peer-reviewed journals and present results at national and international conferences.\nMentor graduate and undergraduate students.\nContribute to grant proposals and progress reports.\nWhat We Offer:\nComprehensive training in structural biology techniques such as cryo-EM and protein crystallization.\nAn opportunity to contribute to high-impact research projects in the fields of neurodegenerative diseases and oncology.\nA supportive environment for skill development and career growth.\nMentorship from senior lab members and access to state-of-the-art research facilities.\nHow to apply:\nPlease submit a single PDF containing your cover letter, curriculum vitae, and a list of publications when applying for this position. In your cover letter, briefly describe your research experience, career goals, and how your expertise aligns with this position. Additionally, include contact information for at least two references. Applications should be emailed to with your full name and the job position title in the subject line. Applications will be reviewed on a rolling basis, and selected candidates will be required to provide at least two confidential letters of reference.\nPlease read following information about this opportunity to learn more.\nRequired Qualifications:\nPh.D. in structural biology, biochemistry, biophysics, or related fields such as chemistry, physical chemistry, or biological structure research, completed within the last three years.\nProficiency in protein expression and purification in eukaryotic and prokaryotic systems.\nExperience in single-particle cryo-EM or crystallization (or both), including structure determination and analysis of protein-ligand complexes.\nAbility to interact effectively with research staff at all levels and work within a multidisciplinary team.\nGood interpersonal, communication, and presentation skills.\nPreferred Qualifications:\nExperience and knowledge in structure-based drug design.\nProficiency in Python programming and its applications in structural biology.\nExperience with other biophysical characterization methods.\nA record of productive and creative research, demonstrated by publications in peer-reviewed journals and presentations at scientific conferences.\nPhysical Requirements:\nAbility to perform experiments while seated or standing for extended periods.\nDexterity to manipulate small laboratory tools and reagents.\nOccasionally involves light physical effort such as moving laboratory equipment or handling reagents.\n816 - Genetics/Genomic Sci - ISM, Icahn School of Medicine","description_format":"text","description_chars":4152,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Health Care","Hospitals & Health Systems","Primary Care & Medical Centers"],"lifecycle":[{"event":"open","at":"2026-11-03T18:44:36Z"}],"visa":[],"liveness":{"score":9,"band":"cold","label":"Long shot","p_open":1,"p_active":0.323,"p_room":0.28,"age_days":635,"expected_fill_days":45,"reasons":["conf:6","velocity","win:tail","crowd:brand"],"computed_at":"2026-11-12T10:38:37Z"},"pay":null,"html_url":"https://alion.io/job/mountsinainyc-postdoctoral-fellow-msh-30001-321","json_url":"https://alion.io/job/mountsinainyc-postdoctoral-fellow-msh-30001-321.json","meta":{"generated_at":"2026-11-13T06:39:47Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":13962,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-14T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.1,"usd":0.01,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":64028},"rest":"https://alion.io/mcp/rest/get_company?id=64028"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fmountsinainyc-postdoctoral-fellow-msh-30001-321"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"free","price":{"credits":0,"usd":0},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fmountsinainyc-postdoctoral-fellow-msh-30001-321"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.1,"usd":0.01},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fmountsinainyc-postdoctoral-fellow-msh-30001-321"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/mountsinainyc-postdoctoral-fellow-msh-30001-321\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fmountsinainyc-postdoctoral-fellow-msh-30001-321"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3698264}},{"tool":"search_jobs","arguments":{"company":"mountsinai.org","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3698264},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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