{"id":1573554,"url":"https://alion.io/job/n-lorem-scientist-upregulation","title":"Scientist - Upregulation","company":{"id":2060970,"name":"n-Lorem","domain":"nlorem.org","url":"https://alion.io/company/nlorem","size_band":"501-1000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Paylocity","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":"junior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["San Diego, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":90000,"max":null,"currency":"USD","period":"year","gross":null,"usd_annual":90000},"salary_estimate":null,"experience_years_min":2,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-07-16T21:01:10Z","employer_posted_date":"2026-10-01","last_verified_at":"2026-10-06T21:00:39Z","board_verified":true,"closed_at":null,"days_open":82,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":82},"description":"Description\nPosition Title: Scientist\nReporting to: Associate Director, ASO Strategy Research\nLocation: San Diego, CA 92121\nEmployment: Full-time\nSalary range: $90K - $120K\nn-Lorem Foundation\nThough n-Lorem is pioneering a novel non-profit model, to provide personalized experimental ASO treatments for free, for life to patients with the rarest of mutations (nano-rare), we are functionally a biotechnology company. We have a large and growing portfolio of ASO medicine discovery programs, ASO medicines in development and multiple clinical programs.\nWith a seasoned leadership team and strategic partnerships, the n-Lorem Foundation provides the framework, funds and access for nano-rare patients who are amenable to our technology to receive personalized ASO medicines for free, for life. We hope that you will consider joining us as we strive to change the world, one nano-rare patient at a time.\nIf you are a professional with strong biotechnology experience and would like to join a cohesive, experienced team committed to the belief that we can change the world one patient, one family at a time, we may have a position for you.\nJob Overview\nWe are seeking a highly motivated Scientist to join our dynamic and innovative Discovery and Research team focused on developing novel antisense therapies for nano-rare diseases. Reporting to the Associate Director, ASO Strategy Research, the successful candidate will play a key role in advancing novel ASO strategies, conducting mechanism-of-action studies, and contributing to next-generation ASO designs.\nThis role will contribute to the development and validation of novel ASO approaches by conducting rigorous in vitro experiments, integrating molecular biology with cell biology, and collaborating across cross-functional teams. This is an exciting opportunity to help build the future of personalized ASO therapeutics in a mission-driven, fast-paced, and innovative environment.\nKey Responsibilities\nExecute, troubleshoot and analyze in vitro screening experiments supporting ASO design, optimization, and mechanistic understanding.\nExecute, troubleshoot, and analyze in vitro screening experiments within our pipeline to evaluate potential clinical compounds.\nWork closely with cross-functional teams to ensure smooth communication and alignment, contributing to the strategic advancement of our research goals.\nPlan and conduct molecular and cellular biology experiments to advance our understanding of antisense oligonucleotide\nAdapt quickly to evolving priorities and provide timely updates and clear communication on research progress.\nCollaborate with internal teams to design and execute experiments that will inform decision-making and drive progress in the development of novel therapeutics.\nMaintain accurate electronic laboratory records, analyze and communicate results, develop reproducible procedures, and collaborate across the team to meet program timelines.\nRequirements\n US work authorization is required.\nBachelor (BSc) or Master’s degree (MSc) or equivalent experience in oligonucleotide research and discovery. 2+ years of industry experience is strongly preferred.\nDrug discovery experience is strongly preferred. \nDemonstrated hands-on proficiency in qPCR, including RNA isolation, cDNA preparation, assay setup, data analysis, and troubleshooting.\nStrong experience with protein analysis techniques, including Western blot and ELISA.\nExperience with molecular cloning, including PCR, primer design, plasmid construction and preparation, bacterial transformation, and sequence verification.\nExperience in culturing and transfecting mammalian cell lines, fibroblasts, and iPSC-derived cells is strongly preferred.\nA proven track record of working in a highly collaborative, team- and mission- oriented environment. Track record of accomplishments, including publications in top-tier scientific journals is preferred. \nStrong experience in performing high-throughput screening assays and data analysis.\nExcellent interpersonal skills, with a proven ability to build and maintain effective working relationships within teams and with external partners.\nAbility to manage assignments in a fast-paced, rapidly changing environment.\nStrong ability to collaborate effectively within a team.\nSelf-starter with a high level of motivation, and a willingness to take initiative and embrace new challenges. \nn-Lorem offers a competitive benefits package including medical, dental, vision, 403(b) and four (4) weeks paid vacation. n-Lorem is a small foundation with an extraordinary mission, to provide hope and potentially help to nano-rare patients today. Every employee in our organization is a significant contributor to this mission. We know that our work could have a profound impact on the life of a patient today.\nFor more information on n-Lorem, please visit our website www.nlorem.org","description_format":"text","description_chars":4861,"description_truncated":false,"requirements":{"experience_years_min":2,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"master","optional":true},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Drug Discovery"],"lifecycle":[{"event":"open","at":"2026-10-01T08:55:42Z"}],"visa":[],"liveness":{"score":9,"band":"cold","label":"Long shot","p_open":1,"p_active":0.319,"p_room":0.28,"age_days":81,"expected_fill_days":23,"reasons":["conf:2","win:tail","crowd:junior"],"computed_at":"2026-10-06T05:45:30Z"},"pay":{"stated_usd_annual":90000,"is_top_pay":true},"html_url":"https://alion.io/job/n-lorem-scientist-upregulation","json_url":"https://alion.io/job/n-lorem-scientist-upregulation.json","meta":{"generated_at":"2026-10-06T21:10:26Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler","counted_by":"address","units_charged":1,"used_today":554,"day_limit":5000,"remaining_today":4446,"minute_limit":60,"resets_at":"2026-10-07T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":2060970},"rest":"https://alion.io/mcp/rest/get_company?id=2060970"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fn-lorem-scientist-upregulation"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fn-lorem-scientist-upregulation"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fn-lorem-scientist-upregulation"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/n-lorem-scientist-upregulation\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fn-lorem-scientist-upregulation"}]}