{"id":1288432,"url":"https://alion.io/job/newlimit-scientist-metabolism","title":"Scientist, Metabolism","company":{"id":171873,"name":"NewLimit","domain":"newlimit.com","url":"https://alion.io/company/newlimit","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"A","score":90,"open_postings":12,"ghost_share":0.083,"stale_share":0,"repost_share":0,"time_to_fill_p50_days":91,"computed_at":"2026-10-20T05:45:00Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["South San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":130000,"max":165000,"currency":"USD","period":"year","gross":null,"usd_annual":165000},"salary_estimate":null,"experience_years_min":5,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Machine Learning","optional":false}],"status":"live","first_seen_at":"2026-09-25T23:56:28Z","employer_posted_date":"2026-09-25","last_verified_at":"2026-10-20T09:11:37Z","board_verified":true,"closed_at":null,"days_open":24,"trust":{"level":"ok","repost_count":0,"flags":["company_stale"],"days_open":24},"description":"Company info\nNewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.\nDescription\nNewLimit is seeking an scientist with experience in liver biology and metabolism to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease. In this role, you will develop and perform assays for hepatocyte function, contribute to team decision making, and serve as a subject matter expert within NewLimit to enable our therapeutic development efforts.\nAs a Scientist on our team, you will:\nCollaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes\nDevelop assays to preclinical models of liver disease to measure hepatocyte function\nEvaluate epigenetic reprogramming payloads using in vivo functional assays to select therapeutic candidates\nDeliver epigenetic reprogramming perturbations to hepatocytes in vivo using multiple transgenic manipulation methods (e.g. viral vectors, lipid nanoparticles)\nAnalyze and interpret experimental data to drive pre-clinical decision making\nRequirements\nPh.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)\nExperience with primary liver cell isolation and functional characterization\nExperience working with mouse models of liver dysfunction\nExperience with transgenic manipulation of liver cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)\nExceptional organizational skills, including detailed experimental record-keeping and the ability to manage multiple concurrent project\nNice to have\nHistory of contributing to a drug development program at the pre-clinical or clinical development stage\nExperience leading the design and execution of pre-clinical studies in mouse models\nExperience with single cell genomics methods\nExperience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)\nBenefits\nNewLimit offers generous benefits to ensure our team can focus on our mission:\nHealth, dental, and vision insurance\n401(k) with company match\nPaid parental leave\nIndustry-leading paid time off (PTO) - 20 days/year for all employees + holidays\nMeals and snacks on-site\nSalary Range: $130,000 to $165,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Learn more at: https://www.newlimit.com/careers \n*This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future","description_format":"text","description_chars":3162,"description_truncated":false,"requirements":{"experience_years_min":5,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Parental leave","Vision insurance"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Cell & Gene Therapy","Regenerative Medicine"],"lifecycle":[{"event":"open","at":"2026-09-26T06:49:49Z"}],"visa":[],"liveness":{"score":86,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.86,"p_room":1,"age_days":24,"expected_fill_days":91,"reasons":["conf:1","win:early"],"computed_at":"2026-10-20T05:45:00Z"},"pay":{"stated_usd_annual":165000,"is_top_pay":true},"html_url":"https://alion.io/job/newlimit-scientist-metabolism","json_url":"https://alion.io/job/newlimit-scientist-metabolism.json","meta":{"generated_at":"2026-10-20T10:12:59Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":11177,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-21T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":171873},"rest":"https://alion.io/mcp/rest/get_company?id=171873"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fnewlimit-scientist-metabolism"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fnewlimit-scientist-metabolism"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fnewlimit-scientist-metabolism"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/newlimit-scientist-metabolism\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fnewlimit-scientist-metabolism"}]}