{"id":2957011,"url":"https://alion.io/job/newlimit-scientist-mrna-analytical-development","title":"Scientist, mRNA Analytical Development","company":{"id":171873,"name":"NewLimit","domain":"newlimit.com","url":"https://alion.io/company/newlimit","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"A","score":91,"open_postings":16,"ghost_share":0.063,"stale_share":0,"repost_share":0,"time_to_fill_p50_days":91,"computed_at":"2026-10-24T06:02:35Z"}},"role":"Biotech","role_family":"Biotech","seniority":"senior","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["South San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":120000,"max":155000,"currency":"USD","period":"year","gross":null,"usd_annual":155000},"salary_estimate":null,"experience_years_min":7,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"ELISA","optional":false},{"name":"HPLC","optional":false},{"name":"Machine Learning","optional":false},{"name":"qPCR","optional":false},{"name":"Mass Spectrometry","optional":true}],"status":"live","first_seen_at":"2026-10-20T21:18:50Z","employer_posted_date":"2026-10-20","last_verified_at":"2026-10-24T23:50:59Z","board_verified":true,"closed_at":null,"days_open":4,"trust":{"level":"ok","repost_count":0,"flags":["company_stale"],"days_open":3},"description":"About NewLimit\nNewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.\nPosition\nWe are seeking a Scientist to establish and grow NewLimit's mRNA analytical testing suite. In this role, you will lead the development of analytical methods to characterize our DNA templates and mRNAs. The assays you build will drive mRNA process development efforts as our programs advance toward the clinic.\nThis is a hands-on, lab-based role within Technical Operations that will interface with Delivery Sciences, research teams, and external CDMOs. It is ideal for an analytical scientist who enjoys building from the ground up and wants to expand their scope.\nWhat you'll do\nAs a member of our team, you will:\nBuild the analytical suite\nDevelop and establish analytical methods for DNA template and mRNA drug substance release and characterization\nLead studies to evaluate method robustness, specificity, sensitivity, precision, accuracy, and linearity, and set phase-appropriate performance criteria\nAct as the mRNA analytical lead for CMC program teams\nEvaluate emerging analytical technologies to expand our internal testing capabilities\nRun and maintain the assays\nPerform routine testing of DNA templates and mRNA materials to support process development and research programs\nInvestigate unexpected impurities, degradation, and atypical results\nMaintain instruments, reference standards, assay controls, and critical reagents\nDocumentation and collaboration\nAuthor method protocols and technical development reports\nSupport method transfer and qualification at CDMOs\nPresent experiment results at team meetings\nManage the outsourcing of advanced analytical techniques to CROs, as needed\nRequirements\nPh.D. in analytical chemistry, biochemistry, molecular biology, chemical engineering, or a related field with 0-3 years of relevant industry experience, or an M.S. with 5+ years or B.S. with 7+ years of relevant industry experience\nExperience with assay development and qualification across a broad range of mRNA analytical methods\nHands-on experience executing and troubleshooting HPLC separations (e.g., IP-RP-HPLC, SEC), capillary electrophoresis, and plate based assays for impurity quantification (e.g. qPCR, ELISA)\nAbility to independently design, execute, and troubleshoot experiments\nAbility to analyze and present complex data sets\nStrong technical writing skills\nExcellent communication and organizational skills\nNice to have\nUnderstanding of the analytical method lifecycle and phase-appropriate method qualification\nExperience with sequencing workflows and data analysis, including Sanger and Oxford Nanopore Technologies\nExperience developing cell-based potency assays\nExperience with LC-MS assays for evaluating poly(A) tail length and capping efficiency\nExperience transferring analytical methods to CDMOs\nBenefits\nNewLimit offers generous benefits to ensure our team can focus on our mission:\nHealth, dental, and vision insurance\n401(k) with company match\nPaid parental leave\nIndustry-leading paid time off (PTO) - 20 days/year for all employees + holidays\nMeals and snacks on-site\nSalary Range: $120,000-155,000*. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers\n*This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.","description_format":"text","description_chars":3966,"description_truncated":false,"requirements":{"experience_years_min":7,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["401k plan","Parental leave","Vision insurance"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Cell & Gene Therapy","Regenerative Medicine"],"lifecycle":[{"event":"open","at":"2026-10-20T21:50:10Z"}],"visa":[],"liveness":{"score":86,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.86,"p_room":1,"age_days":3,"expected_fill_days":91,"reasons":["conf:1","win:early"],"computed_at":"2026-10-24T06:02:35Z"},"pay":{"stated_usd_annual":155000,"is_top_pay":false},"html_url":"https://alion.io/job/newlimit-scientist-mrna-analytical-development","json_url":"https://alion.io/job/newlimit-scientist-mrna-analytical-development.json","meta":{"generated_at":"2026-10-25T00:22:55Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":566,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-26T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":171873},"rest":"https://alion.io/mcp/rest/get_company?id=171873"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fnewlimit-scientist-mrna-analytical-development"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fnewlimit-scientist-mrna-analytical-development"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fnewlimit-scientist-mrna-analytical-development"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/newlimit-scientist-mrna-analytical-development\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fnewlimit-scientist-mrna-analytical-development"}]}