{"id":438313,"url":"https://alion.io/job/newlimit-scientistsenior-scientist","title":"Scientist/Senior Scientist","company":{"id":171873,"name":"NewLimit","domain":"newlimit.com","url":"https://alion.io/company/newlimit","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"A","score":91,"open_postings":16,"ghost_share":0.063,"stale_share":0,"repost_share":0,"time_to_fill_p50_days":91,"computed_at":"2026-10-30T05:48:23Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["South San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":130000,"max":180000,"currency":"USD","period":"year","gross":null,"usd_annual":180000},"salary_estimate":null,"experience_years_min":5,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Machine Learning","optional":false},{"name":"CRISPR","optional":true},{"name":"Single-Cell Sequencing","optional":true}],"status":"live","first_seen_at":"2025-09-17T16:20:36Z","employer_posted_date":"2026-02-09","last_verified_at":"2026-10-31T01:45:53Z","board_verified":true,"closed_at":null,"days_open":408,"trust":{"level":"ghost","repost_count":0,"flags":["stale","company_stale"],"days_open":406},"description":"About NewLimit\nNewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.\nPosition\nNewLimit is seeking an scientist with experience in discovery biology to join our Vascular therapeutic team. Our Vascular program is developing reprogramming medicines to restore youthful function in aged endothelial cells for the treatment of renal, cardiometabolic, and cognitive diseases.\nYour role will focus on developing and deploying assays to measure the functional decline that occurs in endothelial cells with age. You will collaborate closely with our technology teams to help create the first reprogramming medicines for the vascular tissue that supports all others.\nWhat you'll do\nIn your role as a Scientist, you will:\nDevelop functional assays and pre-clinical models to measure endothelial cell function\nCollaborate with our Functional Genomics and Predictive Modeling teams to test reprogramming hypotheses at scale\nMeasure the impact of mRNA reprogramming medicines on endothelial cell function\nEngineer in vivo nucleic acid delivery methods for endothelial cells\nAnalyze and interpret experimental data to drive pre-clinical decision making\nRequirements\nPh.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)\nExperience with primary cell isolation and functional characterization\nExperience working with mouse models (e.g. kidney, cardiovascular, or cognitive disease models)\nExperience with transgenic manipulation of primary cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)\nNice to have\nHistory of contributing to a drug development program at the pre-clinical or clinical development stage\nExperience leading the design and execution of pre-clinical studies in mouse models\nExperience with single cell genomics methods\nExperience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)\nBenefits\nNewLimit offers generous benefits to ensure our team can focus on our mission:\nHealth, dental, and vision insurance\n401(k) with company match\nPaid parental leave\nIndustry-leading paid time off (PTO) - 20 days/year for all employees + holidays\nMeals and snacks on-site\nSalary Range: $130,000 to $180,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.","description_format":"text","description_chars":3103,"description_truncated":false,"requirements":{"experience_years_min":5,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["401k plan","Parental leave","Vision insurance"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Cell & Gene Therapy","Regenerative Medicine"],"lifecycle":[{"event":"open","at":"2026-09-06T07:17:38Z"}],"visa":[],"liveness":{"score":8,"band":"cold","label":"Long shot","p_open":1,"p_active":0.3,"p_room":0.28,"age_days":407,"expected_fill_days":91,"reasons":["conf:1","ghost","win:tail","crowd:"],"computed_at":"2026-10-30T05:48:23Z"},"pay":{"stated_usd_annual":180000,"is_top_pay":true},"html_url":"https://alion.io/job/newlimit-scientistsenior-scientist","json_url":"https://alion.io/job/newlimit-scientistsenior-scientist.json","meta":{"generated_at":"2026-10-31T03:15:19Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":4544,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-01T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":171873},"rest":"https://alion.io/mcp/rest/get_company?id=171873"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fnewlimit-scientistsenior-scientist"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fnewlimit-scientistsenior-scientist"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fnewlimit-scientistsenior-scientist"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/newlimit-scientistsenior-scientist\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fnewlimit-scientistsenior-scientist"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":438313}},{"tool":"search_jobs","arguments":{"company":"newlimit.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":438313},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. Docs: https://alion.io/developers"}}