{"id":2957012,"url":"https://alion.io/job/newlimit-seniorresearch-associate-mrna-engineering","title":"Senior/Research Associate, mRNA Engineering","company":{"id":171873,"name":"NewLimit","domain":"newlimit.com","url":"https://alion.io/company/newlimit","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"A","score":91,"open_postings":16,"ghost_share":0.063,"stale_share":0,"repost_share":0,"time_to_fill_p50_days":91,"computed_at":"2026-10-29T05:49:05Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["South San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":75000,"max":100000,"currency":"USD","period":"year","gross":null,"usd_annual":100000},"salary_estimate":null,"experience_years_min":1,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Machine Learning","optional":false},{"name":"PCR","optional":false},{"name":"HPLC","optional":true}],"status":"live","first_seen_at":"2026-10-20T21:12:53Z","employer_posted_date":"2026-10-20","last_verified_at":"2026-10-29T14:57:26Z","board_verified":true,"closed_at":null,"days_open":8,"trust":{"level":"ok","repost_count":0,"flags":["company_stale"],"days_open":8},"description":"About NewLimit\nNewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.\nPosition\nWe are seeking a Research Associate to join our mRNA Engineering team. In this role, you will generate the mRNAs that power NewLimit's research programs, executing the workflow from DNA template through in vitro transcription (IVT) and downstream purification. You will produce research grade mRNA materials, keep rigorous records of how each batch was made, and work closely with scientists across our research and Delivery Sciences teams. This is a lab-based role ideal for an early-career scientist who wants to build deep expertise in mRNA process development in a fast-paced research environment. You will receive hands-on training from expert scientists and see the direct impact of your work on our programs.\nWhat you'll do\nAs a member of our team, you will:\nmRNA production\nExecute established protocols for DNA template preparation, in vitro transcription, and downstream purification to generate research-grade mRNA\nRun routine analytical assays to assess mRNA integrity and purity\nUnder the guidance of senior scientists, help troubleshoot production issues and contribute to experiments that optimize yield, purity, and recovery\nDocumentation and lab operations\nMaintain detailed, accurate records of all experiments in Electronic Lab Notebooks\nFollow and help maintain SOPs; contribute to drafting and updating protocols as workflows evolve\nManage raw material and mRNA inventory, including sample tracking, storage, and reagent ordering\nMaintain lab equipment and follow lab safety practices\nCollaboration\nWork closely with Delivery Sciences and research teams to coordinate material needs and hand off mRNA for downstream studies\nPresent experiment results at team meetings\nRequirements\nB.S. in Life Sciences, Chemistry, Engineering, or a related field with 1-2 years of relevant full-time industry or academic research experience, or M.S. in Life Sciences\nHands-on experience with molecular biology techniques such as cloning, nucleic acid purification, PCR, and gel electrophoresis\nStrong attention to detail and good documentation practices\nAbility to execute protocols accurately and manage multiple tasks efficiently\nExcellent communication and organizational skills\nInterest in mRNA process science and eagerness to learn new techniques\nNice to have\nExperience producing mRNA through IVT and downstream purification\nFamiliarity with plasmid and mRNA analytics such as HPLC, UV-Vis, and TapeStation/CGE\nExperience with plasmid DNA preparation and linearization\nExposure to column-based purification and tangential flow filtration (TFF)\nFamiliarity with automation liquid handling-based methods for mRNA purification, including experience operating such as Hamiltons and Tecans\nBenefits\nNewLimit offers generous benefits to ensure our team can focus on our mission:\nHealth, dental, and vision insurance\n401(k) with company match\nPaid parental leave\nIndustry-leading paid time off (PTO) - 20 days/year for all employees + holidays\nMeals and snacks on-site\nSalary Range: $75,000 - $100,000*. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers\n*This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.","description_format":"text","description_chars":3933,"description_truncated":false,"requirements":{"experience_years_min":1,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["401k plan","Parental leave","Vision insurance"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Biotechnology","Cell & Gene Therapy","Regenerative Medicine"],"lifecycle":[{"event":"open","at":"2026-10-20T21:50:10Z"}],"visa":[],"liveness":{"score":86,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.86,"p_room":1,"age_days":8,"expected_fill_days":91,"reasons":["conf:3","win:early"],"computed_at":"2026-10-29T05:49:05Z"},"pay":{"stated_usd_annual":100000,"is_top_pay":false},"html_url":"https://alion.io/job/newlimit-seniorresearch-associate-mrna-engineering","json_url":"https://alion.io/job/newlimit-seniorresearch-associate-mrna-engineering.json","meta":{"generated_at":"2026-10-29T18:17:39Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":27065,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-30T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":171873},"rest":"https://alion.io/mcp/rest/get_company?id=171873"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fnewlimit-seniorresearch-associate-mrna-engineering"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fnewlimit-seniorresearch-associate-mrna-engineering"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fnewlimit-seniorresearch-associate-mrna-engineering"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/newlimit-seniorresearch-associate-mrna-engineering\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fnewlimit-seniorresearch-associate-mrna-engineering"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":2957012}},{"tool":"search_jobs","arguments":{"company":"newlimit.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":2957012},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. Docs: https://alion.io/developers"}}