{"id":950729,"url":"https://alion.io/job/novartis-computational-medicinal-chemist","title":"Computational Medicinal Chemist","company":{"id":5824,"name":"Novartis","domain":"novartis.com","url":"https://alion.io/company/novartis","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":86,"open_postings":63,"ghost_share":0,"stale_share":0.556,"repost_share":0.032,"time_to_fill_p50_days":35,"computed_at":"2026-10-15T05:46:00Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"junior","employment_type":"full_time","work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":126000,"max":234000,"currency":"USD","period":"year","gross":null,"usd_annual":234000},"salary_estimate":null,"experience_years_min":2,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"Machine Learning","optional":false},{"name":"Python","optional":true},{"name":"Time Series Forecasting","optional":true}],"status":"live","first_seen_at":"2026-09-15T00:00:00Z","employer_posted_date":"2026-09-15","last_verified_at":"2026-10-16T01:36:18Z","board_verified":true,"closed_at":null,"days_open":31,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":31},"description":"Band\nLevel 4Job Description Summary\nJoin our vibrant and innovative Computer-Aided Drug Discovery (CADD) team in California, where we bring together diverse talents to redefine the way Biomedical Research discovery teams validate and develop new targets. We are a driving force behind drug discovery, and we are now eagerly searching for an exceptional computational scientist like you to join our ranks.Job Description\nInternal Job Title: Senior Expert I, Data Science\nPosition Location: San Diego, CA, Hybrid #LI-Hybrid\nAbout this role:\nJoin our vibrant and innovative Computer-Aided Drug Discovery (CADD) team in California, where we bring together diverse talents to redefine the way Biomedical Research discovery teams validate and develop new targets. We are a driving force behind drug discovery, and we are now eagerly searching for an exceptional computational scientist like you to join our ranks.\nImagine the opportunity to unlock hidden knowledge and disruptive insights from the vast and invaluable data collected by one of the world's most renowned pharmaceutical companies. We need your expertise, experience, and unwavering passion to help us extract this wealth of information. Collaborating with a multidisciplinary group of scientists, you will be at the forefront of crafting inventive solutions to the most pressing drug discovery challenges, forging new paths toward groundbreaking medicines.\nAre you ready to seize this extraordinary chance to make a significant impact in the field of drug discovery? We invite you to embark on this thrilling journey with us, as we push the boundaries of what's possible in scientific exploration. Join our team and be part of a revolution that will shape the future of medicine.\nTogether, we will transform the landscape of drug discovery, accelerate breakthroughs, and change lives. Apply now and let your expertise shine in our dynamic and forward-thinking environment.\nYour Responsibilities Include:\nDrive the design of medicinal chemistry efforts by applying in-depth knowledge of structure-activity relationships (SAR), structure-based and ligand-based drug design, a profound understanding of target biology, and predictive methods for assessing on- and off-target activity, physical properties, pharmacokinetics/pharmacodynamics (PK/PD), and synthetic feasibility.\n\nThrive at the intersection of experimental and groundbreaking digital technologies, with a particular emphasis on expertise in machine learning, active learning and physics-based CADD methodologies as applied to small molecule drug discovery as well as in the induced proximity space.\n\nStay abreast of scientific literature and engage with internal and external scientists to incorporate biological insights into lead characterization and screening initiatives.\n\nCollaborate with interdisciplinary project teams to facilitate effective decision-making throughout the target identification, lead optimization and drug candidate nomination process. This involves applying and developing predictive models based on high-content and time-resolved screening data, including imaging techniques.\n\nDrive hypothesis generation to enhance clinical success rates for programs involving small molecules, peptides, RNAs, protein degradation, molecular glues, transient covalent inhibitors, and kinetic stabilization of drug-target complexes.\n\nTake a leading role in cross-disciplinary mechanistic studies using physics-based modeling and simulation, biophysical characterization, and cellular validation. These studies will inform the strategic targeting strategies of discovery projects, aiming for optimal mechanisms of action (MoAs).\n\nEssential Requirements:\nPhD in medicinal chemistry, computational chemistry, cheminformatics, computational biology, computational chemical biology, or a related field. Candidates with a laboratory-based background in chemistry and biology, supplemented with strong computational experience, are also encouraged to apply.\n\n2+ years of related post-graduate experience, preferably working with project teams in a drug discovery environment.\n\nProven track record of innovation through analogue design, leading to significant impact on discovery projects is a plus.\n\nFamiliarity with computational drug design tools (e.g. Schrdoinger, CCG, OpenEye, etc.), high-performance computing environments, and strong publication history in peer-reviewed journals.\n\nProactively anticipates project needs with a clinical focus.\n\nDemonstrates rigor and diligence in idea substantiation, analogue design, and experimentation.\n\nStrong team orientation with multitasking and adaptability in support and leadership roles.\n\nEffective listener with excellent written and oral communication skills.\n\nProficient in data visualization to effectively communicate insights.\n\nCompensation & Benefits:\nThe salary for this position is expected to range between $126,000 and $234,000 USD annually for Senior Expert I, Data Science. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.\nYour compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.\nUS-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.\nTo learn more about the culture, rewards and benefits we offer our people click here.\nEEO Statement:\nThe Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.\nAccessibility and reasonable accommodations\nThe Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to  +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.\nhttps://www.novartis.com/careers/careers-research/notice-all-applicants-us-job-openings\nSalary Range\n$126,000.00 - $234,000.00Skills Desired\nArtificial Intelligence (AI), Biostatistics, Change Management, Curious Mindset, Data Governance, Data Literacy, Data Quality, Data Science, Data Visualization, Deep Learning, Graph Algorithms, Learning Agility, Machine Learning (ML), Machine Learning Algorithms, Python (Programming Language), Stakeholder Engagement, Statistical Analysis, Time Series Analysis","description_format":"text","description_chars":7398,"description_truncated":false,"requirements":{"experience_years_min":2,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Oncology Therapeutics","Neurology & CNS Therapeutics","Immunology & Inflammation Therapeutics","Cardiometabolic Therapeutics"],"lifecycle":[{"event":"open","at":"2026-09-16T00:43:42Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 8 · green card filings: 2","filings_12m":8,"filings_prev_12m":18,"green_card_filings_12m":2,"median_offered_wage_usd":146500,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":27,"band":"fade","label":"Fading","p_open":1,"p_active":0.449,"p_room":0.6,"age_days":30,"expected_fill_days":35,"reasons":["conf:2","stale_co","velocity","win:late","crowd:junior,brand"],"computed_at":"2026-10-15T05:46:00Z"},"pay":{"stated_usd_annual":234000,"is_top_pay":true},"html_url":"https://alion.io/job/novartis-computational-medicinal-chemist","json_url":"https://alion.io/job/novartis-computational-medicinal-chemist.json","meta":{"generated_at":"2026-10-16T03:50:28Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":426,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-17T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":5824},"rest":"https://alion.io/mcp/rest/get_company?id=5824"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fnovartis-computational-medicinal-chemist"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fnovartis-computational-medicinal-chemist"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fnovartis-computational-medicinal-chemist"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/novartis-computational-medicinal-chemist\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fnovartis-computational-medicinal-chemist"}]}