{"id":2856806,"url":"https://alion.io/job/novartis-principal-scientist-formulation","title":"Principal Scientist - Formulation","company":{"id":5824,"name":"Novartis","domain":"novartis.com","url":"https://alion.io/company/novartis","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"B","score":84,"open_postings":79,"ghost_share":0,"stale_share":0.646,"repost_share":0.013,"time_to_fill_p50_days":27,"computed_at":"2026-10-31T05:58:55Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"lead","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Cambridge, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":108500,"max":201500,"currency":"USD","period":"year","gross":null,"usd_annual":201500},"salary_estimate":null,"experience_years_min":2,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"Mass Spectrometry","optional":false},{"name":"JMP","optional":true},{"name":"Machine Learning","optional":true},{"name":"Python","optional":true}],"status":"live","first_seen_at":"2026-10-19T15:02:55Z","employer_posted_date":"2026-10-19","last_verified_at":"2026-10-31T04:00:59Z","board_verified":true,"closed_at":null,"days_open":11,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":11},"description":"Job Description Summary\nAs a Principal Scientist, you will lead and execute formulation development and characterization strategies for complex biologics-including monoclonal antibodies (mab’s), multispecifics, antibody-drug conjugates (ADCs), and other modalities. You will work closely with a team of more than 10 associates, driving scientific excellence while fostering a culture of collaboration, integrity, and innovation aligned with Novartis values.You will play a key role in shaping formulation strategies during early-stage development and supporting candidate selection by identifying developability risks. This position offers broad exposure to diverse biologics modalities and opportunities to contribute both experimentally and strategically.\nJob Description\nInternal Job Title: Principal Scientist I/II\nPositionLocation: Cambridge, MA, onsite\nJob description\nThe Biologics Center at Novartis Biomedical Research (BRC) is seeking a highly motivated leader and experienced scientist in biologics formulation to join the Analytics, Bioanalytic, and Formulation (ABF) unit. In this role, you will contribute to the development of a diverse portfolio of biotherapeutic modalities.\nThe ABF unit supports the characterization and formulation of therapeutic protein candidates across multiple formats, spanning discovery through transition to development. Our multidisciplinary team brings deep expertise in physicochemical characterization, mass spectrometry, and formulation sciences within a collaborative, global environment.\nRole Overview\nAs a Principal Scientist, you will lead and execute formulation development and characterization strategies for complex biologics-including monoclonal antibodies (mAbs), multispecifics, antibody-drug conjugates (ADCs), and other modalities. You will work closely with a team of more than 10 associates, driving scientific excellence while fostering a culture of collaboration, integrity, and innovation aligned with Novartis values.\nYou will play a key role in shaping formulation strategies during early-stage development and supporting candidate selection by identifying developability risks. This position offers broad exposure to diverse biologics modalities and opportunities to contribute both experimentally and strategically.\nKey responsibilities:\nDesign and execute formulation screening strategies for large-molecule therapeutics, with emphasis on mAbs and related biologic modalities\n\nLead studies to identify stable formulations and communicate results to cross-functional R&D teams\n\nManage team resources, timelines, and deliverables with a strong customer-focused mindset\n\nProvide leadership, mentorship, and direction to team members as the functional manager\n\nPromote a safe, inclusive, and collaborative environment while engaging stakeholders across biologics discovery and technical development\n\nPartner with CMC teams to advance clinical candidates, finalize clinical formulations, and support drug product process development\n\nDevelop stabilization strategies for liquid, frozen, and lyophilized drug product formats for clinical development\n\nApply and interpret biophysical and analytical methods, including DSC, DLS, UV-Vis, turbidity, subvisible particle analysis, viscosity, SEC, and HIC\n\nWork with automation teams to implement high-throughput formulation screening and physicochemical characterization across discovery, optimization, and early development\n\nOperate analytical instrumentation, analyze data, maintain ELN documentation, and author technical reports\n\nContribute to data interpretation, scientific presentations, and cross-functional discussions within the global BRC community\n\nEssential Requirements:\nPhD in biochemistry, biotechnology, chemistry, or a related field with 2+ years of relevant industry experience\n\nProven experience leading, coaching, and developing scientific teams\n\nHands-on expertise in protein formulations and assessment of biophysical properties of the molecule (e.g., DLS, Viscosity, Thermal and colloidal stability)\n\nStrong background in developing strategies for formulations for large-molecule therapeutics, with understanding of early-stage development workflows\n\nExperience designing and executing preformulation studies and interpreting stability-indicating assays (e.g., SEC, CE, charge variants, MS)\n\nDemonstrated problem-solving skills, scientific curiosity, and ability to work independently\n\nExcellent communication, organizational, and multitasking skills\n\nDesirable Requirements:\nKnowledge of viral vector-based gene therapy (AAV, LVV) formulation and characterization\n\nFamiliarity with DoE tools (e.g., JMP) for high-throughput experimental design\n\nExperience working with automated liquid handling systems\n\nCompensation and Benefits:\nThe salary for this position is expected to range between $108,500 and $201,500 per year for Principal Scientist I, and between $119,700 and $222,300 per year for Principal Scientist II. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.\nYour compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.\nUS-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.\nTo learn more about the culture, rewards and benefits we offer our people click here.\nEEO Statement:\nThe Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.\nAccessibility and reasonable accommodations\nThe Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to  call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.\nSalary Range\n$108,500.00 - $201,500.00Skills Desired\nAnalytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Collaboration, Curious Mindset, Data Analysis, Detail-Oriented, Drug Development, Ethics, Gene Therapy, Immunology, Inventory Management, Machine Learning (ML), Medical Research, Molecular Biology, Python (Programming Language), Science","description_format":"text","description_chars":7098,"description_truncated":false,"requirements":{"experience_years_min":2,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Oncology Therapeutics","Neurology & CNS Therapeutics","Immunology & Inflammation Therapeutics","Cardiometabolic Therapeutics"],"lifecycle":[{"event":"open","at":"2026-10-19T15:02:55Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 8 · green card filings: 2","filings_12m":8,"filings_prev_12m":18,"green_card_filings_12m":2,"median_offered_wage_usd":146500,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":57,"band":"ok","label":"Likely open","p_open":1,"p_active":0.632,"p_room":0.9,"age_days":11,"expected_fill_days":27,"reasons":["conf:1","stale_co","velocity","win:mid","comp:brand"],"computed_at":"2026-10-31T05:58:55Z"},"pay":{"stated_usd_annual":201500,"is_top_pay":true},"html_url":"https://alion.io/job/novartis-principal-scientist-formulation","json_url":"https://alion.io/job/novartis-principal-scientist-formulation.json","meta":{"generated_at":"2026-10-31T07:58:19Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":11867,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-01T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":5824},"rest":"https://alion.io/mcp/rest/get_company?id=5824"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fnovartis-principal-scientist-formulation"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fnovartis-principal-scientist-formulation"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fnovartis-principal-scientist-formulation"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/novartis-principal-scientist-formulation\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fnovartis-principal-scientist-formulation"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":2856806}},{"tool":"search_jobs","arguments":{"company":"novartis.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":2856806},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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