{"id":3803129,"url":"https://alion.io/job/novartis-scientist-downstream-process-development","title":"Scientist - Downstream Process Development","company":{"id":5824,"name":"Novartis","domain":"novartis.com","url":"https://alion.io/company/novartis","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":85,"open_postings":84,"ghost_share":0,"stale_share":0.595,"repost_share":0,"time_to_fill_p50_days":26,"computed_at":"2026-11-06T05:58:05Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"middle","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Durham, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":93800,"max":174200,"currency":"USD","period":"year","gross":null,"usd_annual":174200},"salary_estimate":null,"experience_years_min":4,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"Chromatography","optional":false},{"name":"Design of Experiments","optional":false},{"name":"GMP","optional":false}],"status":"live","first_seen_at":"2026-11-05T12:26:06Z","employer_posted_date":"2026-11-05","last_verified_at":"2026-11-06T15:24:04Z","board_verified":true,"closed_at":null,"days_open":1,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":1},"description":"Job Description Summary\nLocation: Durham, North Carolina #onsiteRelocation Support: This role is based in Durham, North Carolina, United States. Novartis is unable to offer relocation support: please only apply if accessible.\nThe Scientist - Downstream Process Development will serve as a downstream functional lead on a gene therapy program, representing downstream process development on the Drug Substance Sub-Team. This role is responsible for defining and advancing program-specific downstream development plans; independently designing, executing, and interpreting studies; and performing hands-on process operations at both small scale and large scale. The Scientist will collaborate with cross-functional partners to deliver program objectives, evaluate new technologies, and contribute to technical best practices within the downstream group.\nJob Description\nMajor Accountabilities:\nServe as the downstream functional lead for early- and mid-phase programs, representing the function on the Drug Substance Sub-Team and driving downstream development plans, technical recommendations, and deliverables in alignment with program strategy.\nIndependently design, execute, and interpret downstream process development studies for AAV and LVV modalities across pre-clinical and clinical-stage assets.\nPerform hands-on downstream process operations at both small scale and large scale, delivering high-quality experimental outputs within program timelines.\nApply a strong statistical and data-driven mindset to analyze process study results, draw scientifically sound conclusions, and inform development strategy.\nStay current with scientific and engineering advances and evaluate new technologies and innovative approaches relevant to viral vector downstream process development.\nApply technical standards and best practices and contribute to continuous improvement and platform development efforts.\nIndependently author technical reports, summarize process development outcomes, and contribute downstream content to regulatory filings, including IND submissions.\nPresent study results and technical recommendations to internal and external stakeholders in cross-functional forums.\nProvide technical guidance and share expertise with team members to support study execution and foster an innovative, collaborative, and scientifically rigorous culture.\nCoordinate laboratory activities and resource needs for assigned studies and collaborate with cross-functional partners to enable efficient execution.\nEssential Requirements:\nBachelor’s degree in biological sciences, pharmaceutical sciences, chemical engineering, or a related technical field with 4 years of relevant experience; Master’s degree with 2 years of relevant experience; or PhD with 0-2 years of relevant experience.\nStrong technical background in downstream process development for biologics, viral vectors, or gene therapy modalities, with hands-on experience designing, executing, and interpreting process development studies.\nExperience with downstream unit operations such as chromatography, depth filtration, tangential flow filtration, ultracentrifugation, impurity clearance, and adventitious virus clearance.\nProficiency in statistical analysis principles and data-driven decision-making, with working knowledge and experience in Design of Experiments (DoE).\nDemonstrated ability to lead technical activities, independently plan and execute studies, solve complex process development challenges, and deliver scientific objectives within agreed timelines.\nStrong communication skills and experience coordinating technical work in a cross-functional setting, with the ability to communicate recommendations clearly and collaborate effectively.\nInnovative mindset with a commitment to continuous improvement and applying new ideas to downstream process development.\nDesired Requirements:\nKnowledge of viral gene therapy and experience with AAV or LVV downstream process development.\nKnowledge of current Good Manufacturing Practices (cGMP) requirements and their application in a process development environment.\nThe salary for this position is expected to range between $93,800 and $174,200 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.\nYour compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.\nUS-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays an\nEEO Statement:\nThe Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.\nAccessibility and reasonable accommodations\nThe Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to  call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.\nSalary Range\n$93,800.00 - $174,200.00Skills Desired","description_format":"text","description_chars":5914,"description_truncated":false,"requirements":{"experience_years_min":4,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":true,"industries":["Oncology Therapeutics","Neurology & CNS Therapeutics","Immunology & Inflammation Therapeutics","Cardiometabolic Therapeutics"],"lifecycle":[{"event":"open","at":"2026-11-05T12:26:06Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 8 · green card filings: 2","filings_12m":8,"filings_prev_12m":18,"green_card_filings_12m":2,"median_offered_wage_usd":146500,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":63,"band":"ok","label":"Likely open","p_open":1,"p_active":0.632,"p_room":1,"age_days":0,"expected_fill_days":26,"reasons":["conf:0","stale_co","velocity","win:early","comp:brand"],"computed_at":"2026-11-06T05:58:05Z"},"pay":{"stated_usd_annual":174200,"is_top_pay":true},"html_url":"https://alion.io/job/novartis-scientist-downstream-process-development","json_url":"https://alion.io/job/novartis-scientist-downstream-process-development.json","meta":{"generated_at":"2026-11-06T19:45:30Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":3360,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-07T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":5824},"rest":"https://alion.io/mcp/rest/get_company?id=5824"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fnovartis-scientist-downstream-process-development"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fnovartis-scientist-downstream-process-development"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fnovartis-scientist-downstream-process-development"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/novartis-scientist-downstream-process-development\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fnovartis-scientist-downstream-process-development"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3803129}},{"tool":"search_jobs","arguments":{"company":"novartis.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3803129},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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