Senior Scientist II, ADME

Salary Range:

Band

Job Description Summary

Internal job title: Senior Scientist II

Location: Basel, Switzerland

The Drug Disposition (DD) group within PK Sciences is seeking a highly motivated, multidisciplinary scientist to support drug discovery and development programs through the application of advanced in vitro ADME models. The successful candidate will bring expertise in complex cell-based systems and mechanistic investigations of drug disposition and drug-drug interactions (DDIs).

In this role, the scientist will develop, validate, and apply advanced in vitro models, including co-cultures, 3D cultures, organoids, and microfluidic platforms, to investigate mechanisms of drug disposition and assess DDI risk for novel drug candidates. This includes evaluating the inhibitory and induction potential of compounds toward drug-metabolizing enzymes and transport proteins. The successful candidate will drive the development and implementation of innovative cell-based DDI assays to expand and continuously enhance the in vitro assay portfolio.

Job Description

Key responsibilities:

• Performing existing assays, establishing new methodologies, analyzing and interpreting complex datasets, and effectively communicating study outcomes to multidisciplinary project teams.

• The scientist will contribute to scientific strategy and decision-making by providing mechanistic insights that support candidate progression and regulatory submissions.

• Responsibilities also include preparing technical reports, study summaries, and scientific documentation in compliance with quality standards and project timelines.

Essential Requirements:

• MSc or PhD in a relevant life science discipline.

• Extensive hands-on experience with mammalian cell culture and cell-based assays.

• Experience with advanced in vitro models, including 3D cultures, organoids, or co-culture systems.

• Strong understanding of ADME sciences and drug-drug interactions.

• Experience with bioanalytical techniques in particular LC-MS/MS.

• Proven ability to develop, optimize, and troubleshoot complex in vitro assays.

• Strong data analysis, interpretation, and scientific communication skills.

• Demonstrated ability to work collaboratively in multidisciplinary project tea

Benefits & Rewards

At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen.

Expected Annual Base Salary Range for role:

• 76,300.00 - 141,700.00 CHF Annual

The base salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically.

In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters.

The rewards of being part of our team go far beyond base pay and incentives. We also offer a variety of competitive benefits in kind to help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeing resources and global recognition programs. In addition, we provide flexible and hybrid working options, where possible, and minimum 14 weeks paid parental leave.

In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters. Long-term equity awards granted at group level may also be part of your package. Further details will be provided during the application process.

Pay equity is a fundamental principle of our employment policy and reflects our commitment to create a diverse, equitable and inclusive environment that treats all employees with dignity and respect, as outlined in our Code of Ethics.

Read our brochure to learn more about our global total rewards offering:

https://www.novartis.com/sites/novartis_com/files/novartis-life-handbook.pdf

Note: Benefits and compensation may vary by country and are subject to local legal requirements, including provisions of collective bargaining agreements where applicable. A full overview of your compensation package, including any relevant collective bargaining agreement details applicable to your role based on your employment location and Novartis employer entity, will be communicated separately to you during the application process.

Commitment to Diversity and Inclusion / EEO

Novartis is committed to building an outstanding, inclusive work environment and diverse teams’ representativeof the patients and communities we serve.

Accessibility and accommodation

Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a

position, please send an e-mail to [email protected] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Skills Desired