{"id":557690,"url":"https://alion.io/job/orca-bio-general-manager-commercial-manufacturing-facility","title":"General Manager, Commercial Manufacturing Facility","company":{"id":4299,"name":"Orca Bio","domain":"orcabio.com","url":"https://alion.io/company/orca-bio","size_band":"501-1000","is_staffing_agency":false,"is_intermediary":false,"ats_vendor":"Lever","truth_index":{"grade":"B","score":81,"open_postings":16,"ghost_share":0,"stale_share":0.75,"repost_share":0,"time_to_fill_p50_days":58,"computed_at":"2026-09-24T05:45:00Z"}},"role":"Management","role_family":"Management","seniority":"staff","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"hiring_geo_confidence":"structured","locations":["Sacramento, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":265000,"max":340000,"currency":"USD","period":"year","gross":null,"usd_annual":340000},"salary_estimate":null,"experience_years_min":15,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-09-08T18:47:27Z","employer_posted_date":"2026-09-08","last_verified_at":"2026-09-24T11:00:52Z","board_verified":true,"closed_at":null,"days_open":15,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":15},"description":"Summary of Position: The General Manager/Site Head, Commercial Manufacturing will have overall leadership responsibility for our 200+ employee, 24/7 Sacramento manufacturing site, which has undergone significant recent expansion and continues to scale. This leader will serve as the senior site executive accountable for operational performance, manufacturing execution, people, financial performance, quality and compliance, and long-term growth.\nReporting to the Chief Quality Officer/EVP Manufacturing, the General Manager will work closely with Orca Bio’s executive leadership team to strengthen the site’s operating model, culture and capabilities while driving reliable execution, operational efficiency and continuous improvement. This is a highly visible role for a strategic business leader and hands-on operator who brings a strong sense of urgency and stays close to day-to-day operations.\nLocation: candidate must live and work full-time in Sacramento; relocation support will be provided as needed.\nResponsibilities\nSite Leadership & General Management\nServe as the senior leader and overall business operator for the Sacramento commercial manufacturing site.\nEstablish and build upon site priorities, governance, operating rhythms and performance objectives aligned with Orca Bio’s business goals.\nLead the site leadership team and create clear accountability, fast decision-making and strong cross-functional execution.\nBuild the organization, systems and capabilities required to support continued commercial growth.\nProvide executive leadership with clear visibility into site performance, risks, opportunities and resource needs.\nManufacturing & Operational Performance\nLead commercial GMP manufacturing operations and ensure reliable delivery of patient-critical products.\nDrive improvements in throughput, productivity, cycle time, schedule adherence and right-first-time performance.\nEstablish and build upon site KPIs and use data to identify bottlenecks, solve problems and improve performance.\nBring a strong sense of urgency and a creative, pragmatic mindset to simplifying processes and improving how work gets done.\nMaintain strong quality, safety and compliance standards while enabling efficient, responsive operations.\nLead production ramp-up, capacity expansion and operational scaling.\nPeople & Organization Leadership\nBuild, develop and retain a high-performing site leadership team and organization.\nCreate a culture of ownership, accountability, collaboration and continuous improvement.\nBe a visible, hands-on leader who stays close to frontline operations and actively engages employees in solving problems.\nDevelop leadership capability and succession plans for critical roles.\nPartner with Human Resources on workforce planning, organizational design and employee engagement.\nFinancial & Business Management\nPartner with Finance and executive leadership on budgets, headcount, capital requirements and long-range plans.\nManage site resources against business priorities and commercial demand.\nDrive productivity and cost efficiency while protecting product quality and patient supply.\nEnsure the site has the workforce, equipment, systems and infrastructure required for future growth.\nQualifications\nBachelor’s degree in engineering, life sciences, business, operations or a related discipline; advanced degree preferred.\n15+ years of progressive leadership experience in commercial biologics, cell/gene therapy, pharmaceuticals, or radiopharmaceuticals.\nSignificant senior leadership experience as a Site Head, General Manager, Plant Manager or equivalent, with broad accountability for GMP manufacturing operations.\nDemonstrated track record of improving manufacturing performance, efficiency, reliability and operational discipline.\nExperience leading large, cross-functional organizations and building high-performing teams.\nStrong business, financial and operational acumen, with a practical understanding of cGMP requirements.\nDemonstrated ability to operate with urgency, make sound risk-based decisions and challenge established ways of working.\nExperience with production ramp-up, commercialization and/or significant capacity expansion.","description_format":"text","description_chars":4186,"description_truncated":false,"requirements":{"experience_years_min":15,"management_years_min":15,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":true,"industries":["Industrial Real Estate","Biotechnology","Health Care","Cell & Gene Therapy"],"lifecycle":[{"event":"open","at":"2026-09-09T00:08:03Z"}],"liveness":{"score":60,"band":"ok","label":"Likely open","p_open":1,"p_active":0.602,"p_room":1,"age_days":15,"expected_fill_days":58,"reasons":["conf:2","stale_co","win:early"],"computed_at":"2026-09-24T05:45:00Z"},"pay":{"stated_usd_annual":340000,"is_top_pay":true},"html_url":"https://alion.io/job/orca-bio-general-manager-commercial-manufacturing-facility","json_url":"https://alion.io/job/orca-bio-general-manager-commercial-manufacturing-facility.json","meta":{"generated_at":"2026-09-24T11:24:36Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers"}}