{"id":1543261,"url":"https://alion.io/job/ossium-health-operations-manager-hpc","title":"Operations Manager, HPC","company":{"id":689635,"name":"Ossium Health","domain":"ossiumhealth.com","url":"https://alion.io/company/ossiumhealth","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":null},"role":"Management","role_family":"Management","seniority":"senior","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Indianapolis, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":110000,"max_usd":206000,"period":"year","method":"role_seniority_country_remote_cell","sample_n":4830},"experience_years_min":5,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"CAPA","optional":false},{"name":"GMP","optional":false},{"name":"HPC","optional":false},{"name":"Statistical Process Control","optional":true}],"status":"live","first_seen_at":"2026-09-30T10:00:02Z","employer_posted_date":"2026-09-30","last_verified_at":"2026-10-27T08:37:05Z","board_verified":true,"closed_at":null,"days_open":26,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":26},"description":"About Ossium\nOssium’s mission is to improve the health, vitality, and longevity of human beings through bioengineering. We develop, manufacture, and bank cell therapy products that apply the power of stem cell science to revolutionize treatment for patients with blood, immune, and orthopedic diseases. At Ossium, we empower our employees, maintain the highest standards of operational excellence, and are a force for good.\nAbout the Job\nThe Operations Manager, HPC leads the hematopoietic progenitor cell (HPC) production team that turns organ donor vertebral bodies into bone marrow and other cell therapy products. You will own the HPC value stream at our Indianapolis facility, from donor intake and allocation to cell processing and cryopreservation, and the supervisors and operators who run it across shifts. You will also lead the cross-functional Core Team that ensures reliable production of HPC, Marrow and work closely with Tissue Production, MSAT, Engineering, Quality, and Supply Chain. This is a hands-on leadership role in a cleanroom environment: you will spend real time on the floor, and you will also own the metrics, the investigations, and the plan for scaling the team.\nRequired Qualifications\nBS/BA in a technical field or equivalent experience\n5+ years of manufacturing or related experience\n3+ years in a formal people-leadership role\nWorking knowledge of aseptic technique, cleanroom operations, and cGTP/cGMP requirements\nExperience owning deviations, investigations, and CAPAs, including root cause analysis\nExcellent written and oral communication skills, with the ability to present results to cross-functional stakeholders\nHigh level of attention to detail and the ability to operate with organization and urgency in a dynamic environment\nPreferred Qualifications\nAdvanced degree in a relevant scientific discipline\nDirect experience managing teams in an aseptic manufacturing environment\nTrained in statistical process control and continuous improvement tools and methodologies\nExperience supporting FDA or other regulatory and accreditation inspections\nExperience with process validation and technology transfer from development into routine production\nFamiliarity with lean or tiered daily management practices\nKey Responsibilities\nOwn daily HPC production output from donor intake through cryopreservation and initial inventory, ensuring every gift is used for its authorized purpose\nManage HPC Production Supervisors across shifts, ensuring processes are scheduled with appropriately trained and qualified personnel\nServe as operator, verifier, or trainer during clinical production as needed\nDevelop and report production metrics such as throughput, yield, right-first-time documentation, deviation rate, and cycle time, and drive action where targets are missed\nPerform technical review of production batch records and ensure traceability of donor products through final disposition\nWrite and oversee event reports, investigations, risk assessments, and CAPAs, including effectiveness checks\nLead operational changes through project management, document creation, batch record revision, and risk assessment\nServe as hiring manager for HPC production roles and oversee onboarding, qualification, and ongoing training for the team\nServe as Core Team Leader for HPC, Marrow: own the Core Team charter, lead the daily meeting, set the agenda for weekly meetings, and drive cross-functional alignment across Production, Quality, Engineering, and MSAT\nAccountable for the Core Team balanced scorecard covering safety, quality, process control and capability, variability reduction, throughput, supply chain planning, productivity, training, and equipment reliability\nKeep the HPC process in control, capable, and compliant, prioritizing effectiveness before efficiency, and lead periodic formal process reviews and Annual Product Review feedback\nEstablish the Core Team floor presence schedule and ensure development plans are in place for frontline supervisors and staff\nPartner with Tissue Production, MSAT, Engineering, Quality, Supply Chain, and Facilities on shared suites, materials, equipment, and process improvements\nPhysical Requirements\nMust be able to work in a moderately noisy environment\nMust be able to work around biohazardous materials and chemicals\nRequired to work the majority of the shift aseptically in a controlled environment with limited breaks. This environment requires special gowning (ie. over the head, face, hands, feet and body).\nMust be able to lift, push, pull and/or carry up to 50 lbs\nMust have sufficient manual dexterity, hand/finger coordination, wrist mobility, wrist stability, and grip strength to handle, feel, grasp, manipulate, and operate objects, manual and power tools, equipment, and controls safely and accurately.\nRegularly required to sit, stand, walk, squat, balance, climb, stoop, kneel, crouch and reach with arms.\nWe offer a full slate of employee benefits including:\nCompetitive salaries\nStock options\n401(k) matching\nMedical, dental and vision coverage\nFour weeks of PTO accrued (vacation & sick time) annually + 11 company holidays\nEmployer paid life insurance and long term disability\nGym membership/recreational sports reimbursements\nOssium Health provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability, protected veteran status, sexual orientation, gender identity, gender expression, or any other protected characteristic. Our Equal Employment Opportunity Policy Statement and the Know Your Rights: Workplace Discrimination is Illegal Poster reaffirm this commitment. Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.\nIf reasonable accommodation is needed, please contact our People Team at  or 650-285-0603. Ossium Health complies with federal and state disability laws and makes reasonable accommodations for applicants and candidates with disabilities.\nPrincipals / direct applicants only please. Recruiters, please do not contact this job poster. \nEqual Opportunity Employer/Veterans/Disabled","description_format":"text","description_chars":6226,"description_truncated":false,"requirements":{"experience_years_min":5,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Gym membership","Life insurance","Stock options"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Blood & Tissue Banks"],"lifecycle":[{"event":"open","at":"2026-09-30T21:33:25Z"}],"visa":[],"liveness":{"score":58,"band":"ok","label":"Likely open","p_open":1,"p_active":0.775,"p_room":0.75,"age_days":26,"expected_fill_days":36,"reasons":["conf:1","win:late"],"computed_at":"2026-10-27T05:46:45Z"},"pay":null,"html_url":"https://alion.io/job/ossium-health-operations-manager-hpc","json_url":"https://alion.io/job/ossium-health-operations-manager-hpc.json","meta":{"generated_at":"2026-10-27T09:19:18Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":10386,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-28T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":689635},"rest":"https://alion.io/mcp/rest/get_company?id=689635"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fossium-health-operations-manager-hpc"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fossium-health-operations-manager-hpc"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fossium-health-operations-manager-hpc"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/ossium-health-operations-manager-hpc\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fossium-health-operations-manager-hpc"}]}