{"id":1286214,"url":"https://alion.io/job/p-addyanjiuyuan","title":"CADD研究员","company":{"id":2789013,"name":"DP Technology","domain":"dp.tech","url":"https://alion.io/company/dp-8","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Feishu","truth_index":{"grade":"D","score":50,"open_postings":190,"ghost_share":0.837,"stale_share":0,"repost_share":0,"time_to_fill_p50_days":null,"computed_at":"2026-10-01T05:45:00Z"}},"role":"AI/ML","role_family":"AI/ML","seniority":"middle","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Shanghai, China"],"countries":["CN"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":30000,"max_usd":87000,"period":"year","method":"global_role_cell_scaled_by_country","sample_n":585},"experience_years_min":3,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2022-08-25T01:41:41Z","employer_posted_date":"2026-09-26","last_verified_at":"2026-09-29T11:40:33Z","board_verified":false,"closed_at":null,"days_open":1499,"trust":{"level":"ghost","repost_count":0,"flags":["stale","company_stale"],"days_open":1498},"description":"岗位职责 / Responsibilities\n1. 基于计算辅助药物设计（CADD）策略，支持药物发现项目中的靶点分析、分子设计、候选化合物筛选与优化等工作。\n2. 熟练运用分子对接（Docking）、分子动力学模拟（MD）、自由能计算等常规计算方法，对分子-靶标相互作用机制进行研究和解释。\n3. 结合结构生物学、药物化学、计算化学及生物学信息，为项目提供可执行的分子设计建议与机制洞察。\n4. 跟踪并应用前沿的 AI驱动药物设计（AIDD）技术，包括但不限于分子生成、性质预测、分子打分、候选优选等相关方法。\n5. 支持药物研发相关项目的计算设计与分析工作。\n6. 能够独立完成计算结果分析、技术总结及方案汇报，并能够清晰地向项目团队传达研究结论。\n7. 与药化、生物、算法、数据科学等团队协同合作，推动计算策略在实际研发项目中的落地应用。\n8. 持续关注计算药物设计、分子模拟、自由能方法以及 AI for Drug Discovery 领域的最新进展，并推动新技术在项目中的应用。\n任职要求 / Requirements\n1. 具有物理化学、计算化学、计算生物学、药物设计或相关专业背景; \n2. 具备良好的科学思维、分析能力与问题解决能力，能够独立承担课题并推动项目进展。\n3. 博士（应届）毕业生，或硕士学历且具有 3 年及以上相关工作经验。\n4. 具备扎实的分子相互作用、蛋白-配体识别、热力学、构象动态及结构基础药物设计理论基础。\n5. 熟悉常规 CADD 技术体系，包括但不限于：分子对接（Docking）、分子动力学模拟（MD）、自由能微扰（FEP）、结构基础或配体基础药物设计方法， 熟悉常用的各类药物设计相关数据库; \n6. 在小分子、多肽、抗体优化、RDC、ADC等一个或多个领域有相关经验; \n7. 熟练使用Linux系统，精通Python等至少一门编程语言; \n8. 能够将英语作为工作语言，流畅参与日常技术讨论、项目汇报及跨团队协作; \n9. 具有较强的团队合作意识和跨学科协作能力。\n加分项：\n1. 具有创新药研发或工业界药物发现项目经验者优先。\n2. 具备将计算结果与实验数据（如活性、亲和力、SAR、药效结果等）结合分析的经验。\n3. 具备机器学习的应用或开发经验者优先","description_format":"text","description_chars":955,"description_truncated":false,"requirements":{"experience_years_min":3,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":null,"security_clearance":false,"languages":[{"language":"Chinese","level":"Advanced (C1)","optional":false}]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["AI for Science"],"lifecycle":[{"event":"open","at":"2026-09-26T04:37:59Z"}],"liveness":{"score":5,"band":"cold","label":"Long shot","p_open":1,"p_active":0.166,"p_room":0.28,"age_days":1498,"expected_fill_days":24,"reasons":["conf:42","stale_co","velocity","ghost","win:tail","crowd:brand"],"computed_at":"2026-10-01T05:45:00Z"},"pay":null,"html_url":"https://alion.io/job/p-addyanjiuyuan","json_url":"https://alion.io/job/p-addyanjiuyuan.json","meta":{"generated_at":"2026-10-02T02:02:21Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","usage":{"tier":"crawler","counted_by":"address","units_charged":1,"used_today":2659,"day_limit":5000,"remaining_today":2341,"minute_limit":60,"resets_at":"2026-10-03T00:00:00Z"}}}