Associate Research Scientist - Organoid

Key Responsibilities

• Develop, optimize, and characterize robust human 3D organoid/spheroid models, including multicellular co-culture systems, for disease modelling and therapeutic efficacy applications spanning metabolic, fibrotic, inflammatory, and toxicological indications.
• Perform advanced mammalian cell culture, including primary cells, stem cells, and co-culture systems, with multicellular organoid assembly experience preferred, maintaining strong experimental rigor and reproducibility throughout.
• Design and standardize reproducible protocols for 3D organoid model generation, maintenance, maturation, differentiation, cryopreservation, recovery, and quality control, demonstrating strong command of tissue engineering principles.
• Design, execute, and optimize functional assays evaluating viability, metabolism, DMPK studies, tissue-specific function, biomarker expression, and therapeutic response.
• Working proficiency in techniques such as RT-qPCR, ELISA, Western blotting, ICC, IF, and flow cytometry, along with histology pipelines for tissue characterization, is required.
• Expertise in fluorescence and confocal microscopy with quantitative image analysis to characterize structural and functional readouts of 3D organoid models; exposure to high-content imaging and automated image analysis is a plus.
• Design experiments independently, analyze complex biological datasets, and interpret results, with solid grounding in experimental design, statistical analysis, and scientific data interpretation. Ability to prepare publication-quality figures, technical reports, and presentations is essential.
• Contribute to mechanism-of-action studies by integrating molecular, functional, and phenotypic datasets, and develop, optimize, and validate novel assays and workflows that enhance the reproducibility, throughput, and translational relevance of organoid-based models; experience in biomarker identification, selection, and validation is preferred
• Maintain comprehensive scientific documentation, including lab notebooks, SOPs, protocols, and validation reports, in compliance with internal quality systems.
• Support scientific publications, IP generation, grant proposals, and external collaborations through data generation, analysis, and scientific writing; publication or patent experience is a plus.
• Collaborate effectively across biology, bioengineering, translational research, computational biology, and process development to drive project objectives, with strong communication, presentation, and interpersonal skills to thrive in a fast-paced, multidisciplinary research environment.

Qualifications and Experience

PhD in a relevant discipline with 0-2 years of postdoctoral and/or industry research experience in Liver and Lung Organoids; OR

Master’s degree with 4+ years relevant research experience in Cell Biology, Molecular Biology, Biotechnology, Biochemistry, Regenerative Medicine, Tissue Engineering, Biomedical Sciences, or a related discipline