{"id":3000913,"url":"https://alion.io/job/pathos-director-clinical-operations-program-lead","title":"Director, Clinical Operations Program Lead","company":{"id":689188,"name":"Pathos","domain":"pathos.com","url":"https://alion.io/company/pathos-2","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Rippling","truth_index":null},"role":"Biotech","role_family":"Biotech","seniority":"head","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["New York, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":209000,"max_usd":364000,"period":"year","method":"role_seniority_country_remote_cell","sample_n":375},"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"AI Agents","optional":false},{"name":"GCP","optional":false},{"name":"Multimodal AI","optional":false}],"status":"live","first_seen_at":"2026-09-18T17:44:32Z","employer_posted_date":"2026-09-18","last_verified_at":"2026-10-29T04:22:50Z","board_verified":true,"closed_at":null,"days_open":40,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":40},"description":"Drug development shouldn’t be guesswork, not when patients are waiting.\nPathos is an AI and technology company that develops drugs. Foundry, our platform,\ndecides which ones.\nWe are not a biotech that uses AI. We are redesigning drug development from first\nprinciples around an AI and technology core. Our Foundation Model reads across DNA,\nRNA, pathology, and clinical text on 200+ petabytes of Multimodal data. Our Foundry\nplatform turns that model into live portfolio decisions: which asset to invest in, which trial\ndesign to pivot, which program to stop. In 2026, every major portfolio decision\nat Pathos was Foundry-informed, a Platform-Informed Decisions score of 4 out of 4.\nThe three engines of the platform are Scout (finds assets other companies would miss),\nFoundry (decides where capital and clinical attention go), and Sprint (executes trials with\nAI agents doing the work that used to require a full biotech). We call it a biotech\ncompany in a box.\nWe are well-capitalized. We have three clinical-stage oncology programs, and a co-development partnership with a top-five pharma. Our leadership has\nnearly two decades of company-building experience and multiple successful exits behind\nthem.\nHow We Build\nPathos does not operate like a traditional biotech. There is no middle management.\nThere are no layers of approval. Every function, Clinical, Legal, Finance, Regulatory,\nEngineering, Research, is built the same way: small teams of 3-5 subject matter experts,\neach commanding 30-50 AI agents to do the work that used to require dozens of people.\nEveryone builds. Everyone ships. Product velocity is measured in hours, not weeks. A team of 40-50 operators does the work of a traditional biotech of 300. Every dollar saved\non overhead is a dollar deployed into a clinical program.\nThe people who thrive here are operators: deep experts who can specify what needs to\nhappen, orchestrate AI agents to execute at scale, and make high-judgment calls that\ncompound over time. If you have spent your career building and shipping in your\ndomain, this is the environment where that experience becomes a superpower.\nAbout the Role\nWe are seeking a Director, Clinical Operations Program Lead to own the operational strategy and end-to-end execution of our clinical programs. At Pathos, that does not mean building and running a large operations team. It means acting as the operator who sets clinical operational direction and commands a fleet of AI agents to carry it out, from study startup through database lock. You will translate asset strategy into executable trials, then orchestrate agentic systems to run the day-to-day: tracking timelines and enrollment, monitoring site and vendor performance, surfacing risks, and drafting the operational documentation that used to take a full team.\nThis is a foundational hire on the Pathos Clinical Operations team, reporting to the Chief Clinical Operations Officer and partnering closely with Clinical Development, Regulatory, Data Management, Biometrics, and Research. You are equally comfortable setting program-level strategy and getting into the detail of a single study. You know how to get a trial from concept to first-patient-in and through close-out, how to hold CROs and vendors accountable, and how to make the high-judgment calls that keep timelines, quality, and budget in balance, with AI agents handling the operational load so your time goes to the decisions that matter.\nWhat You Will Do\nProgram Strategy & Operational Leadership\nOwn the clinical operational strategy for one or more oncology programs, translating asset and development strategy into actionable, phase-appropriate operational plans. \nServe as the single point of accountability for operational delivery, on time, on budget, and to quality, across assigned studies. \nOrchestrate AI agents to assess program-level risk, model timeline and enrollment scenarios, and surface the trade-offs you need to make the call. \nOwn external study budgets and forecasts, from vendor spend through program-level financial planning.\nAgent-Driven Trial Execution\nRun studies end to end (startup, site activation, enrollment, conduct, monitoring oversight, and close-out through database lock) with AI agents doing the operational heavy lifting. \nDeploy agentic systems for continuous trial oversight: tracking site and vendor performance, detecting emerging risks and data trends, and escalating issues before they become problems. • Select, contract, and manage CROs and specialty vendors, holding them accountable to scope, timelines, quality, and budget, with agents monitoring deliverables in real time. \nDirect AI agents to draft, assemble, and maintain operational documentation, trial master files, plans, and reports, keeping everything inspection-ready.\nQuality, Compliance & Cross-Functional Partnership\nEnsure all trial activity, human and agent-executed alike, meets ICH/GCP standards, applicable regulations, and Pathos SOPs. \nContribute clinical operations content to regulatory filings and health-authority interactions. \nPartner across Clinical Development, Regulatory, Data Management, Biometrics, and Research to keep the program aligned and unblocked. \nSet the operational bar and standards that both your team and your AI agents execute against as the function scales.\nWho You Are\nRequired Qualifications\nBachelor's degree in a scientific, nursing, or related field (advanced degree a plus). \n10+ years of clinical operations experience in biotech, pharma, or CRO settings, including demonstrated program-level strategic leadership. \nProven track record leading clinical trials end to end across Phase 1 to 3, from startup through database lock. \nDeep, hands-on clinical trial management experience: CRO and vendor selection and oversight, timelines, budgets, enrollment, and monitoring strategy. \nDirect experience in oncology drug development. \nExperience owning and managing large external study budgets. \nStrong command of ICH/GCP and applicable global regulatory requirements. \nExperience in a small or emerging biotech as well as a larger pharma or CRO environment, with the versatility to operate strategically and tactically in each.\nPreferred Qualifications\nExperience taking an oncology asset through pivotal or late-stage trials. \nTrack record building or scaling clinical operations infrastructure (SOPs, vendor frameworks, or operating models) from an early stage. \nA technology-forward operator: you have used AI, ML, or automation to run or accelerate clinical operations, and you are energized by orchestrating agentic systems rather than growing headcount.\nWhat Success Looks Like\nClinical trials that start, enroll, and read out on time, on budget, and to quality, with AI agents absorbing the operational load and no surprises gating the program. \nWell-run CROs and vendors delivering to a clear, accountable standard under continuous, agent-driven oversight. \nInspection-ready programs and clean, defensible clinical operations content in regulatory submissions.\nLocation\nThis is a hybrid role, requiring 3 days per week onsite, 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