{"id":4323795,"url":"https://alion.io/job/pfizer-senior-computational-chemist","title":"Senior Computational Chemist","company":{"id":3480,"name":"Pfizer","domain":"pfizer.com","url":"https://alion.io/company/pfizer","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":90,"open_postings":39,"ghost_share":0,"stale_share":0.59,"repost_share":0.026,"time_to_fill_p50_days":13,"computed_at":"2026-11-14T05:58:10Z"}},"role":"Biotech","role_family":"Biotech","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["La Jolla, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":106000,"max":176600,"currency":"USD","period":"year","gross":null,"usd_annual":176600},"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":false,"relocation_package":true,"has_equity":false,"technologies":[{"name":"Machine Learning","optional":false},{"name":"NumPy","optional":false},{"name":"Python","optional":false},{"name":"AI Agents","optional":true},{"name":"AWS","optional":true},{"name":"Copilot","optional":true},{"name":"GCP","optional":true},{"name":"GitHub","optional":true},{"name":"HPC","optional":true},{"name":"SLURM","optional":true},{"name":"SQL","optional":true}],"status":"live","first_seen_at":"2026-11-13T00:00:00Z","employer_posted_date":"2026-11-13","last_verified_at":"2026-11-14T22:30:21Z","board_verified":true,"closed_at":null,"days_open":1,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":1},"description":"Why Join MLCS in Medicine Design\nPfizer Medicine Design brings together medicinal chemistry, discovery sciences, and MLCS to invent medicines that deliver meaningful benefits to patients. MLCS plays a central role in enabling data centric and ML-driven discovery, with opportunities to make impact directly on drug discovery projects through clear communication of actionable insights.\nPosition Summary\nThe Machine Learning & Computational Sciences (MLCS) organization within Medicine Design at Pfizer partners broadly across R&D to deliver computational, cheminformatics, and machine learning (ML) capabilities that accelerate drug discovery and development. MLCS supports medicinal chemistry and drug design teams by enabling data-driven decision making, scalable cheminformatics platforms, and impactful scientific applications across the discovery pipeline.\nWe are seeking a Senior Computational Chemist with a strong cheminformatics background and a proven track record of independent scientific delivery. The ideal candidate is expected to lead applied computational and cheminformatics efforts across project teams, develop and shape technical approaches across multiple initiatives, and contribute durable, reusable capabilities that strengthen MLCS platform infrastructure and influence how computational chemistry and cheminformatics is best practiced across Medicine Design. With strong communication skills and adept at building productive partnerships, the successful candidate will thrive working in cross-functional teams with talented scientists across disciplines.\nKey Responsibilities\nChemistry Data Enablement (Data Science / Data Engineering):\nLead the design, curation, and application of high-quality chemistry and pharmacology datasets used across multiple discovery programs.\n\nArchitect and deploy data pipelines and transformations that enable scalable, reproducible data analytics and modeling.\n\nSet expectations for data quality and fitness-for-purpose in collaboration with scientific and platform stakeholders.\n\nApplied ML and Cheminformatics:\nIndependently frame ambiguous medicinal chemistry problems into clear computational strategies and decision-support analyses.\n\nDrive the application of ML and Cheminformatics models to high-impact drug discovery questions.\n\nCritically assess model performance and limitations, guiding appropriate interpretation and use in project decisions.\n\nRapid Prototyping & Front-End Development:\nDeliver robust, reusable, and well-documented scientific software aligned with modern best practices.\n\nLead rapid prototyping of chemistry and cheminformatics applications to validate workflows and user experience with end users.\n\nPartner closely with chemists and software teams to evolve successful prototypes into production-ready solutions.\n\nCross-Functional Collaboration & Delivery:\nEffectively bridge chemistry, data science, and software perspectives to align stakeholders around robust solutions.\n\nInfluence projects through technical insight, credibility, and data-driven recommendations.\n\nContribute to the scientific culture of MLCS through knowledge sharing, internal talks, and cross-team collaboration.\n\nRequired Qualifications\nPh.D. in Computational Chemistry, Cheminformatics, Computer Science, or related fields; or M.S. with substantial relevant industry experience.\n\nDeep understanding of cheminformatics concepts, including molecular representations, similarity methods, QSAR, virtual screening, chemical spaces\n\nExperience analyzing large, complex chemistry-related datasets.\n\nStrong proficiency in Python and cheminformatics toolkits (RDKit or equivalent).\n\nExperience with standard data science packages (numpy, pandas, etc)\n\nProven experience applying ML models in real-world discovery projects.\n\nPractical experience with rapid application or UI prototyping in a scientific context.\n\nPreferred Qualifications\nPrior experience in pharmaceutical or biotech drug discovery environments.\n\nFamiliarity with deploying and scaling scientific workflows and applications.\n\nExperience with database design and processing (SQL, RestAPI).\n\nExperience in large-scale data handling and developing data pipelines.\n\nFamiliarity developing code in collaborative manner (GitHub, code review & sharing).\n\nFamiliarity working in HPC (e.g. SLURM) or cloud-based (AWS, GCP) environments.\n\nFamiliarity with efficient use of agentic coding environments (GitHub Copilot or equivalent)\n\nAdditional Information Relocation support available Work Location Assignment: Hybrid\nThe annual base salary for this position ranges from $106,000.00 to $176,600.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.Relocation assistance may be available based on business needs and/or eligibility.\nSunshine Act\nPfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.\nEEO & Employment Eligibility\nPfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.\nPfizer endeavors to makewww.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please . This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.\nTo learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.\nInformation & Business Tech","description_format":"text","description_chars":8009,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Relocation assistance"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":true,"industries":["Prescription Drugs","Oncology Therapeutics","Infectious Disease Therapeutics"],"lifecycle":[{"event":"open","at":"2026-11-14T22:30:21Z"}],"visa":[{"country":"US","licensed_sponsor":true,"adverts_offering_sponsorship_24m":91,"sanctioned_now":false,"evidence":"H-1B filings in 12 months: 47 · green card filings: 2","filings_12m":47,"filings_prev_12m":91,"green_card_filings_12m":2,"median_offered_wage_usd":127296,"route":null,"cap_exempt":false,"checked_at":"2026-11-14T07:33:33+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)","Alion: sponsorship offered in the employer's own job adverts (24 months)"],"filings_for_role_12m":0}],"liveness":{"score":86,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.86,"p_room":1,"age_days":1,"expected_fill_days":13,"reasons":["conf:0","win:early","comp:brand"],"computed_at":"2026-11-14T23:19:36Z"},"pay":{"stated_usd_annual":176600,"is_top_pay":false},"html_url":"https://alion.io/job/pfizer-senior-computational-chemist","json_url":"https://alion.io/job/pfizer-senior-computational-chemist.json","meta":{"generated_at":"2026-11-14T23:19:36Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":31117,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-15T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.1,"usd":0.01,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":3480},"rest":"https://alion.io/mcp/rest/get_company?id=3480"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fpfizer-senior-computational-chemist"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"free","price":{"credits":0,"usd":0},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fpfizer-senior-computational-chemist"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.1,"usd":0.01},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fpfizer-senior-computational-chemist"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/pfizer-senior-computational-chemist\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fpfizer-senior-computational-chemist"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":4323795}},{"tool":"search_jobs","arguments":{"company":"pfizer.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":4323795},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. Docs: https://alion.io/developers"}}