{"id":3157578,"url":"https://alion.io/job/pfizer-senior-principal-scientist-bioprocess-development","title":"Senior Principal Scientist, Bioprocess Development","company":{"id":3480,"name":"Pfizer","domain":"pfizer.com","url":"https://alion.io/company/pfizer","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":86,"open_postings":22,"ghost_share":0,"stale_share":0.773,"repost_share":0,"time_to_fill_p50_days":13,"computed_at":"2026-10-25T05:49:26Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"lead","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["New York, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":124400,"max":207400,"currency":"USD","period":"year","gross":null,"usd_annual":207400},"salary_estimate":null,"experience_years_min":8,"visa_sponsorship":true,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Design of Experiments","optional":false}],"status":"live","first_seen_at":"2026-10-23T15:02:05Z","employer_posted_date":"2026-10-23","last_verified_at":"2026-10-24T01:07:44Z","board_verified":false,"closed_at":null,"days_open":2,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":2},"description":"ROLE SUMMARY:\nWe are seeking a highly motivated Senior Principal Scientist to lead the Polysaccharide Fermentation and Purification Development group within Vaccines, Early BioProcess Development. The successful candidate will lead the group, provide strategic, innovative scientific and technical leadership for upstream and downstream bioprocess development supporting diverse vaccines portfolio.\nThis role is part of a cross-functional team focused on polysaccharide fermentation and purification process development for carbohydrate- and other modality-based conjugate vaccines. The successful candidate will be responsible for the development of scalable manufacturing processes across microbial fermentation, purification and scale up, shaping process development plans, integrating technical input across disciplines, mentoring scientific staff, managing risks, and influencing key program decisions from early-stage development through technology transfer and clinical manufacturing readiness.\nROLE RESPONSIBILITIES:\nLead and develop a high-performing team of upstream and downstream process development scientists and engineers, drive the vaccines program, while setting scientific direction, establishing priorities, building technical capability, and ensuring high standards for rigor, quality, and accountability.\nDrive development of robust, scalable, and transferable manufacturing processes.\nProvide strategic leadership, serve as a strategic scientific owner for vaccine programs by defining process development strategy, aligning technical plans with program objectives, and ensuring decisions are informed by scientific evidence, manufacturability, timelines, and regulatory expectations.\nCollaborate closely with colleagues across EBPD, Vaccines, BTxPS, and PGS organizations to support integrated process development and product advancement.\nPartner with cross-functional projects team, provide project updates, technical strategies, risks, propose mitigation plans, communicate trade-offs, and drive alignment among all stakeholders.\nLead technology transfer strategy for developed processes to internal and external clinical manufacturing sites, including preparation and review of process descriptions, technical packages, risk assessments, process control rationale, and troubleshooting plans.\nFoster innovation through adoption of emerging bioprocess technologies, automation, digital tools, and data-driven approaches that enhance process efficiency, product quality, scalability, and robustness.\nContinuously evaluate process performance, equipment capabilities, and experimental workflows to identify gaps, mitigate risks, and propose practical improvements.\nMentor and develop scientific talent while building organizational capability and succession strength.\nBASIC QUALIFICATIONS:\nPhD in Chemical Engineering, Biochemical Engineering, Bioengineering, Microbiology, Biochemistry, or a related discipline, with a minimum of 8 years of relevant experience.\nDemonstrated expertise in vaccine process development, preferably for capsular or exopolysaccharides, conjugate vaccines, bacterial antigens, carrier proteins, or other microbial-based vaccine platforms.\nHands-on technical depth in microbial fermentation and developing polysaccharide recovery and purification processes.\nStrong knowledge of polysaccharide critical quality attributes, in-process controls, design of experiments, scale-down model development, and process characterization.\nDemonstrated ability to collaborate effectively across cross-functional teams, including process development, analytical, formulation, quality, regulatory, and manufacturing groups, to advance complex vaccine development programs.\nAbility to drive projects, translate scientific strategies into executable development plans, manage competing priorities, and guide teams through ambiguity while maintaining accountability for program deliverables.\nExperience authoring and reviewing development reports, process descriptions, technology-transfer packages, risk assessments, and CMC content, with practical understanding of quality-by-design principles, data integrity, and phase-appropriate regulatory expectations for clinical manufacturing.\nExcellent organizational, interpersonal, and communication skills to effectively influence and collaborate in a fast-paced, multi-disciplinary team environment. \nCandidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.\nPHYSICAL/MENTAL REQUIREMENTS:\nStandard laboratory conditions - sitting, standing, primarily lab based\nAbility to perform mathematical calculations and ability to perform complex data analysis\nADDITIONAL DETAILS:\nWork Location Assignment: On Premise\nLast date to apply is November 15, 2026\nThe annual base salary for this position ranges from $124,400.00 to $207,400.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.Relocation assistance may be available based on business needs and/or eligibility.\nCandidates must be authorized to be employed in the U.S. by any employer.\nU.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.\nSunshine Act\nPfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.\nEEO & Employment Eligibility\nPfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.\nPfizer endeavors to makewww.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please . This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.\nTo learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.\nResearch and Development","description_format":"text","description_chars":8607,"description_truncated":false,"requirements":{"experience_years_min":8,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Relocation assistance"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":true,"industries":["Bioprocessing","Prescription Drugs","Oncology Therapeutics","Infectious Disease Therapeutics"],"lifecycle":[{"event":"open","at":"2026-10-23T15:02:05Z"}],"visa":[],"liveness":{"score":63,"band":"ok","label":"Likely open","p_open":1,"p_active":0.632,"p_room":1,"age_days":1,"expected_fill_days":13,"reasons":["conf:28","stale_co","velocity","win:early","comp:brand"],"computed_at":"2026-10-25T05:49:26Z"},"pay":{"stated_usd_annual":207400,"is_top_pay":true},"html_url":"https://alion.io/job/pfizer-senior-principal-scientist-bioprocess-development","json_url":"https://alion.io/job/pfizer-senior-principal-scientist-bioprocess-development.json","meta":{"generated_at":"2026-10-26T02:16:43Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":3025,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-27T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":3480},"rest":"https://alion.io/mcp/rest/get_company?id=3480"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fpfizer-senior-principal-scientist-bioprocess-development"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fpfizer-senior-principal-scientist-bioprocess-development"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fpfizer-senior-principal-scientist-bioprocess-development"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/pfizer-senior-principal-scientist-bioprocess-development\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fpfizer-senior-principal-scientist-bioprocess-development"}]}