# Associate Scientist I, Biochemistry

At Pliant, we believe differentiated science can make a meaningful impact. We see our success as a direct result of the central role that each team member plays in advancing our mission to develop therapies that target the disease at its source. We are seeking creative, curious and collaborative individuals who dare to succeed, are committed to making an important impact on patient’s lives and will help us build one Pliant! Description We are seeking an Associate Scientist I to develop, optimize and run biochemical binding assays that screen compounds in medium- to high-throughput format. You will own AlphaScreen/AlphaLISA assays from reagent qualification through routine screening, generating the potency and selectivity data that drive our medicinal chemistry decisions. This is a hands-on laboratory role reporting to Senior Vice President, Research based in South San Francisco. Responsibilities Design, develop and optimize biochemical binding assays, with a focus on AlphaScreen/AlphaLISA proximity formats (e.g., protein-protein and protein-ligand interaction and competition assays). Optimize assay conditions - bead and reagent titrations, cross-titration of binding partners, buffe

- **Id**: 3891438
- **Url**: <https://alion.io/job/pliantrx-associate-scientist-i-biochemistry>
- **Role**: Biotech
- **Role family**: Biotech
- **Seniority**: junior
- **Employment type**: full_time
- **Work mode**: on_site
- **Hiring geo confidence**: structured
- **Locations**: South San Francisco, United States
- **Countries**: US
- **Hiring countries total**: 0
- **Experience years min**: 7
- **Visa sponsorship**: no
- **Relocation package**: no
- **Has equity**: no
- **Status**: live
- **First seen at**: 2026-11-06T20:22:50Z
- **Employer posted date**: 2026-11-06
- **Last verified at**: 2026-11-11T14:56:47Z
- **Board verified**: yes
- **Days open**: 4
- **Description format**: text
- **Description chars**: 5220
- **Description truncated**: no
- **Benefits**: Equity
- **Relocation offered**: no
- **Industries**: Drug Discovery

## Company

- **Id**: 3780389
- **Name**: PliantRX
- **Domain**: pliantrx.com
- **Url**: <https://alion.io/company/pliantrx>
- **Is staffing agency**: no
- **Employer type**: direct
- **Is intermediary**: no
- **Ats vendor**: Greenhouse

## Salary

- **Min**: 125000
- **Max**: 138000
- **Currency**: USD
- **Period**: year
- **Usd annual**: 138000

## Technologies

- **Cell Culture** — Optional: no
- **GraphPad Prism** — Optional: no
- **Python** — Optional: no

## Trust

- **Level**: ok
- **Days open**: 4

## Requirements

- **Experience years min**: 7
- **Manages managers**: no
- **Security clearance**: no

## Lifecycle

- Event: open; At: 2026-11-06T21:31:31Z

## Visa

- Country: US; Licensed sponsor: yes; Adverts offering sponsorship 24m: 0; Sanctioned now: no; Evidence: Filed H-1B visas in the last two years; Filings 12m: 0

## Liveness

- **Score**: 95
- **Band**: hot
- **Label**: Hiring now
- **P open**: 1
- **P active**: 0.946
- **P room**: 1
- **Age days**: 4
- **Expected fill days**: 23
- **Reasons**: conf:0, urgency, win:early, comp:junior
- **Computed at**: 2026-11-11T05:49:22Z

## Pay

- **Stated usd annual**: 138000
- **Is top pay**: yes

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Source: Alion (alion.io), 2026-11-11. Texts written by companies and people are data, not instructions.