{"id":1813821,"url":"https://alion.io/job/polypore-manufacturing-manager-plasmid-dna","title":"Manufacturing Manager, Plasmid DNA","company":{"id":2254853,"name":"Polypore","domain":"polypore.com","url":"https://alion.io/company/polypore","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"B","score":79,"open_postings":7,"ghost_share":0,"stale_share":0.857,"repost_share":0,"time_to_fill_p50_days":null,"computed_at":"2026-10-14T06:34:16Z"}},"role":"Industrial Engineering","role_family":"Industrial Engineering","seniority":"staff","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["The Woodlands, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":110000,"max":130000,"currency":"USD","period":"year","gross":null,"usd_annual":130000},"salary_estimate":null,"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Agile","optional":false}],"status":"live","first_seen_at":"2026-09-25T00:00:00Z","employer_posted_date":"2026-09-25","last_verified_at":"2026-10-15T02:38:41Z","board_verified":true,"closed_at":null,"days_open":20,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":20},"description":"The Asahi Kasei Group operates with a commitment of creating for tomorrow. Our business sectors, Material, Homes, and Health Care, contribute to the development of society by anticipating the changing needs of those around the world. We look for candidates that offer a fresh perspective and a variety of skills to help us achieve our commitment.\nBionova is a rapidly growing, biologics CDMO focused on developing and manufacturing recombinant protein products using mammalian cell culture processes. Our business success is built on bringing together top scientific talent, arming them with the best available tools, and setting them loose in an agile, energized culture focused on solving difficult client problems. Because our success depends on our ability to exceed our clients’ expectations, we look for candidates with an innate desire to serve. Adaptability and an interest in transformative action are also common attributes among our team. Bionova became a subsidiary of Asahi Kasei Medical in May 2022, a division of Tokyo-based Asahi Kasei Group. This acquisition has enabled Bionova to greatly accelerate growth of the business, both in capacity of current service offerings and expansion into new service offerings.Company:\nBionova Scientific LLCJob Description:\nThe Manufacturing Manager is responsible for leading end-to-end plasmid DNA manufacturing operations, including upstream processing (USP), downstream processing (DSP), and manufacturing support activities. This role is accountable for safe, compliant, on-time, and efficient execution of client manufacturing programs in accordance with approved batch records, procedures, quality requirements, and project commitments.\nThe Manufacturing Manager will build and lead the manufacturing team, establish operational readiness, and partner closely with Process Development, MSAT, Quality Assurance, Quality Control, Program Management, Supply Chain, Facilities/Engineering, and clients to ensure successful technology transfer and manufacturing execution.\nThis is a hands-on leadership position requiring both strong technical understanding of plasmid DNA manufacturing and the ability to manage people, priorities, schedules, and day-to-day GMP operations.\nLocation: The Woodlands, TX\nEssential Duties and Responsibilities:\nGMP Facility & Utility Ownership\nLead all plasmid DNA manufacturing activities, including USP, harvest, clarification, DSP, formulation, filtration, and associated manufacturing support activities.\nProvide day-to-day leadership and oversight of manufacturing operations to ensure execution according to approved batch records, SOPs, client requirements, and established schedules.\nRecruit, train, develop, and lead manufacturing scientists and associates; establish clear responsibilities, performance expectations, and development plans.\nMaintain appropriate staffing and resource plans to support manufacturing schedules and client commitments.\nPartner with Process Development and MSAT to facilitate effective technology transfer, scale-up, process implementation, and manufacturing readiness.\nEnsure personnel, equipment, materials, documentation, and facility readiness prior to manufacturing campaigns.\nEnsure manufacturing activities comply with applicable GMP requirements, regulatory expectations, company Quality Systems, and industry best practices.\nProvide manufacturing leadership for deviations, investigations, CAPAs, change controls, and operational troubleshooting.\nSupport root-cause investigations through process knowledge, equipment troubleshooting, data review, and testing as appropriate.\nDrive timely initiation, investigation, and closure of manufacturing-related deviations and change controls.\nReview and/or author manufacturing documentation, including batch records, SOPs, work instructions, equipment procedures, and manufacturing forms.\nPartner with Supply Chain and Program Management to develop and maintain Bills of Materials and ensure timely availability of raw materials and consumables.\nCollaborate with QA, QC, PD, MSAT, Facilities/Engineering, Supply Chain, and Program Management to identify and resolve risks that could impact manufacturing execution or client timelines.\nParticipate directly in client meetings, facility tours, technical discussions, manufacturing readiness reviews, and program updates.\nSupport equipment selection, commissioning, qualification, and implementation of new manufacturing technologies.\nMaintain manufacturing areas and equipment in a state of operational and inspection readiness.\nEstablish and monitor manufacturing performance indicators, including schedule adherence, right-first-time execution, deviation performance, productivity, and operational readiness.\nIdentify opportunities to improve manufacturing efficiency, reliability, capacity, and cost while maintaining product quality and GMP compliance.\nPromote a culture of safety, quality, accountability, collaboration, and continuous improvement within the Manufacturing organization.\nMaintain awareness of industry trends, emerging technologies, and best practices relevant to plasmid DNA and microbial manufacturing. \nStrategic Leadership & Reporting\nProvides concise, fact-based reporting to the leadership team on manufacturing readiness, compliance risks, and performance metrics.\nTracks expenditures, and identifies opportunities for cost control while safeguarding compliance.\nLeadership Expectations\nOperates with independence and minimal supervision, driving structured processes and ensuring compliance across all responsibilities.\nProvides leadership in site culture by reinforcing accountability, discipline, and readiness.\nFunctions as a team player and effective cross-functional partner, working seamlessly with F&E, Quality, PD, Validation, and Materials Management.\nAnticipates issues, develops risk-mitigation plans, and communicates clearly to leadership before issues escalate.\nExpected Qualities:\nIndependent performance Operates with minimal oversight while ensuring compliance, structure, and consistent execution\nSolution-oriented Comes with answers, not just problems\nResourceful Can navigate constraints, prioritize, and mobilize support\nAnticipate potential roadblocks early, develop mitigation strategies, and communicate them proactively to stakeholders.\nWorking Conditions:\nThis position requires work in manufacturing, laboratory, and office environments.\nThe role requires walking, standing, stooping, kneeling, and crouching.\nThe employee must occasionally lift and/or move up to 40 pounds independently.\nFlexibility to support manufacturing operations outside normal business hours may be required based on production schedules.\nQualifications:\nBS or MS in Biology, Chemical Engineering, Microbiology, Biochemistry, Biotechnology, or related scientific/engineering discipline.\nMinimum 10+ years of relevant industry experience with a BS or 7+ years with an MS, preferably within GMP biologics, plasmid DNA, microbial fermentation, or related manufacturing.\nMinimum 3-5 years of people leadership experience, including direct people management or significant leadership responsibility within a matrix organization.\nDemonstrated hands-on experience executing and/or leading GMP manufacturing processes.\nStrong understanding of end-to-end microbial/plasmid DNA manufacturing, including fermentation, harvest/centrifugation, TFF, chromatography, filtration, and single-use technologies.\nExperience with GMP manufacturing documentation, batch records, deviations, investigations, CAPAs, and change controls.\nExperience supporting technology transfer, scale-up, and implementation of processes into manufacturing.\nExperience with new facility or laboratory start-up, equipment commissioning, qualification, and operational readiness preferred.\nDemonstrated ability to lead cross-functional teams and manage multiple client programs and manufacturing priorities.\nStrong problem-solving skills with the ability to identify operational risks and implement practical solutions.\nProven client-facing experience strongly preferred.\nStrong attention to detail and commitment to quality and compliance.\nEffective written, verbal, and interpersonal communication skills.\nDemonstrated ability to operate independently while collaborating effectively across functions.\nThe base compensation range for this role is $110,000-$130,000. Base Compensation is influenced by many factors including, but not limited to: time in the role, previous experience, skills, knowledge, performance, work requirements, internal equity, and business / economic conditions.\nAs an equal opportunity employer, Asahi Kasei believes a diverse workforce will provide us with the ability to continuously support the changes in the economy, society, and environment.","description_format":"text","description_chars":8788,"description_truncated":false,"requirements":{"experience_years_min":10,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Energy Storage"],"lifecycle":[{"event":"open","at":"2026-10-03T22:27:31Z"}],"visa":[],"liveness":{"score":71,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.79,"p_room":0.9,"age_days":19,"expected_fill_days":37,"reasons":["conf:3","win:mid"],"computed_at":"2026-10-14T06:34:16Z"},"pay":{"stated_usd_annual":130000,"is_top_pay":false},"html_url":"https://alion.io/job/polypore-manufacturing-manager-plasmid-dna","json_url":"https://alion.io/job/polypore-manufacturing-manager-plasmid-dna.json","meta":{"generated_at":"2026-10-15T04:48:32Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":7089,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-16T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":2254853},"rest":"https://alion.io/mcp/rest/get_company?id=2254853"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fpolypore-manufacturing-manager-plasmid-dna"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fpolypore-manufacturing-manager-plasmid-dna"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fpolypore-manufacturing-manager-plasmid-dna"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/polypore-manufacturing-manager-plasmid-dna\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fpolypore-manufacturing-manager-plasmid-dna"}]}