{"id":1579907,"url":"https://alion.io/job/precede-biosciences-associate-scientist-scientist-i-computational-test-development","title":"Associate Scientist / Scientist I, Computational Test Development","company":{"id":3794744,"name":"Precede Biosciences","domain":"precede.bio","url":"https://alion.io/company/precede-2","size_band":"201-500","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Lever","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":"junior","employment_type":"full_time","work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Boston, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":110000,"max":150000,"currency":"USD","period":"year","gross":null,"usd_annual":150000},"salary_estimate":null,"experience_years_min":3,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"AWS","optional":false},{"name":"Python","optional":false}],"status":"live","first_seen_at":"2026-08-18T15:57:20Z","employer_posted_date":"2026-08-18","last_verified_at":"2026-10-14T16:50:20Z","board_verified":true,"closed_at":null,"days_open":57,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":57},"description":"The Opportunity\nWe are seeking a motivated and detail-oriented Associate Scientist / Scientist I to join our Computational Test Development team at Precede Biosciences. Reporting to our Senior Director, Computational Test Development, this role is focused on the execution and analysis that underpins our diagnostic assay characterization and validation programs.\nThis is a hands-on computational role. You will run analyses, build and maintain quality assessment frameworks, execute in silico simulations, and generate the data-driven outputs that feed directly into our regulatory submissions. If you are energized by rigorous data analysis, take pride in clean and reproducible work, and are excited to contribute to diagnostics that could change how cancer is detected and treated, we want to hear from you.\nAbout Us\nWe are pioneering an advanced, minimally invasive, comprehensive epigenomics platform with the potential to profoundly impactthe research and development of new medicines and the use of approved medicines in clinical practice across a number ofconditions, including cancer. More information on our company and platform can be found on our company website and in our seminal publication in Nature Medicine.\nWe care deeply about creating a place where folks can do their best work from the start and have intentionally created an environment that is defined by purpose, teamwork, and excellence. This means nurturing team spirit, facing challenges together, and collaboratively solving complex problems, while also ensuring a strong focus on individual initiative, accountability, and delivery.\nWhat You'll Do\nAssay Characterization & Validation\nExecute data analyses supporting assay characterization across multiple epigenomic and NGS-based diagnostic tests - from raw data processing through performance metric generation\n\nDesign and implement quality assessment frameworks to evaluate assay and pipeline performance, including QC metric definition, threshold setting, and failure mode identification\n\nRun and interpret validation experiments in close coordination with wet lab and senior computational team members, contributing to study execution against pre-defined protocols\n\nPursue defined research questions semi-independently - taking a scoped problem, designing the analytical approach, executing, and returning well-documented results\n\nIn Silico Simulation & Thresholding\nDesign and run in silico simulations to model assay behavior under variable conditions - including signal dropout, coverage non-uniformity, and input DNA variability\n\nDevelop and apply statistical approaches to threshold setting and performance boundary definition, supporting limit of detection and analytical range characterization\n\nSystematically explore parameter sensitivity across bioinformatics pipelines to assess model robustness and inform feature selection\n\nRegulatory Support & Communication\nProduce clear, thorough documentation of all analyses code, methods, results, and interpretation to the standard required under design controls\n\nContribute to the authoring of SOPs and analytical summary reports\n\nPartner closely with wet lab scientists to ensure computational analyses are grounded in experimental reality and that results are communicated in accessible, actionable terms\n\nPresent analytical findings clearly in team meetings and cross-functional settings\n\nContribute to a collaborative team environment by sharing code and knowledge openly and proactively\n\nWho You Are\nMSc in computational biology, bioinformatics, biostatistics, or a closely related quantitative field with 3-4 years of industry or post-graduate research experience in a data-intensive biological or biomedical setting, Ph.D. preferred\n\nStrong proficiency in R and Python for data analysis, visualization, and reproducible reporting - you write, own, and document your own code\n\nExperience with cloud computing environments (AWS) for running scalable analyses\n\nDemonstrated ability to execute analytical plans with precision and efficiency, managing multiple tasks without a drop in quality or documentation standards\n\nFamiliarity with NGS data types and standard processing pipelines - alignment, QC, coverage analysis, or equivalent\n\nClear and organized communicator - written documentation, results presentations, and cross-functional interactions alike\n\nComfortable working in a fast-paced startup environment, following defined protocols while contributing ideas for improvement\n\nNice to have:\nExposure to regulated environments - CLIA, CAP, FDA IVD, or design controls in any form\n\nExperience with epigenomic data types - methylation, cfDNA, chromatin accessibility, or ChIP-seq\n\nFamiliarity with statistical thresholding or limit of detection frameworks for diagnostic applications\n\nExperience contributing to SOPs, validation reports, or other regulated documentation","description_format":"text","description_chars":4868,"description_truncated":false,"requirements":{"experience_years_min":3,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"master","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Diagnostic Tests & IVD","Genomics & Genetic Testing"],"lifecycle":[{"event":"open","at":"2026-10-01T12:35:02Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"Filed H-1B visas in the last two years","filings_12m":0,"filings_prev_12m":2,"green_card_filings_12m":0,"median_offered_wage_usd":null,"route":null,"cap_exempt":false,"checked_at":"2026-10-03T21:08:04+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":18,"band":"cold","label":"Long shot","p_open":1,"p_active":0.502,"p_room":0.36,"age_days":56,"expected_fill_days":29,"reasons":["conf:2","win:tail","crowd:junior"],"computed_at":"2026-10-14T06:34:16Z"},"pay":{"stated_usd_annual":150000,"is_top_pay":true},"html_url":"https://alion.io/job/precede-biosciences-associate-scientist-scientist-i-computational-test-development","json_url":"https://alion.io/job/precede-biosciences-associate-scientist-scientist-i-computational-test-development.json","meta":{"generated_at":"2026-10-14T19:32:07Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":25727,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-15T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":3794744},"rest":"https://alion.io/mcp/rest/get_company?id=3794744"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fprecede-biosciences-associate-scientist-scientist-i-computational-test-development"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fprecede-biosciences-associate-scientist-scientist-i-computational-test-development"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fprecede-biosciences-associate-scientist-scientist-i-computational-test-development"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/precede-biosciences-associate-scientist-scientist-i-computational-test-development\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fprecede-biosciences-associate-scientist-scientist-i-computational-test-development"}]}