{"id":3999428,"url":"https://alion.io/job/probably-genetic-senior-computational-biologist","title":"Senior Computational Biologist","company":{"id":685488,"name":"Probably Genetic","domain":"probablygenetic.com","url":"https://alion.io/company/probablygenetic","size_band":"11-50","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Ashby","truth_index":{"grade":"B","score":78,"open_postings":3,"ghost_share":0,"stale_share":0.667,"repost_share":0,"time_to_fill_p50_days":127,"computed_at":"2026-11-09T06:03:00Z"}},"role":"Biotech","role_family":"Biotech","seniority":"senior","employment_type":"full_time","work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":160000,"max":200000,"currency":"USD","period":"year","gross":null,"usd_annual":200000},"salary_estimate":null,"experience_years_min":4,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"Machine Learning","optional":false},{"name":"Multimodal AI","optional":false},{"name":"Python","optional":false}],"status":"live","first_seen_at":"2026-11-09T22:20:07Z","employer_posted_date":"2026-11-09","last_verified_at":"2026-11-10T02:49:27Z","board_verified":true,"closed_at":null,"days_open":0,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":0},"description":"About Probably Genetic\nProbably Genetic is changing the lives of patients living with severe, complex diseases. Our data platform is used by drug developers and patient advocacy groups to develop and launch treatments for these patients. Our technology discovers undiagnosed patients online, analyzes their disease state using machine learning and at-home testing, and enables compliant communication with patients. In doing so, we help patients access diagnoses, clinical trials, and treatments as early as possible.\nWe are a tight-knit group of hard-working, ambitious problem solvers united by a mission greater than ourselves. We do well by doing right by patients. We are developing some of the most cutting-edge solutions in healthcare, and our roadmap is packed with innovations in bioinformatics, AI, and drug development. We have built a lean, all-star team to help us bring our vision to life, and we want you to be a part of it.\nProbably Genetic has raised multiple rounds of funding from Silicon Valley’s best investors, including Threshold, Khosla, and Y Combinator, and offer competitive salaries, comprehensive benefits, and meaningful early stage equity.\nAbout the Role:\nProbably Genetic has built one of the deepest phenotyped genetic disease cohorts in the U.S. by facilitating patients' access to genetic testing. We are now using this rich database for target discovery.\nWe're hiring a Senior Computational Biologist to own our bio data pipelines and interpretation end-to-end. . You'll take our data from QC through positive control recovery to novel, causal, direction-of-effect target hypotheses, and collaborate closely with our team on prioritizing new data modalities to collect.. In addition, your results will be used by our ML researchers to train ML models on multi-modal data and support target discovery. . This is a hands-on, first-of-its-kind role reporting to our VP of R&D.\nWhat You'll Do:\nBio data processing and QC: take over, improve and fully automate our in-house pipeline for genetic data analysis\n\nRun power analyses and use your insights to inform which phenotypes and indications we prioritize, how we scale our database, and which data modalities we collect\n\nProve our data and pipelines recover known gene-phenotype associations and approved target-indication pairs, and replicate them against public resources\n\nConduct association and causal gene mapping in a selected indication, incl. via rare variant burden tests, colocalization tests, and Mendelian randomization\n\nPartner with ML researchers on data preparation, multi-modal integration and shared evaluation\n\nHand off prioritized targets to wet lab validation and inform in vitro experimental plans and priorities\n\nWho You Are:\nPhD in statistical genetics, computational biology, bioinformatics, or similar, plus 4+ years post-PhD in academia or industry\n\nProven track record (via shareable projects or publications) of hands-on experience in processing, analysing and interpreting genetic / genomic data; Working knowledge of public human genetic and functional genomics resources (e.g. gnomAD, GTEx, Open Targets, ClinVar)\n\nStrong Python skills; experience with workflow managers (e.g., Snakemake) and comfortable working with cloud-scale genomic data resources\n\nEnough ML fluency to collaborate closely, support data preparation and have productive discussions\n\nEnergized by our mission: develop new treatments for patients who have none\n\nBonus: target discovery or human genetics experience in biotech or biopharma; experience with genetic disease and/or disease-enriched cohorts; multi-omics (e.g., transcriptomics, proteomics)\n\nAs with all new hires at Probably Genetic, you will also need to be:\nA good person. We work with some of the most marginalized populations on the planet and empathy is key\n\nPatient-focused and motivated to have a lasting, positive impact on humanity\n\nComfortable in a fast-paced, often ambiguous environment with rapid change\n\nAction-oriented and excited to build a company from the ground up\n\nWhat we offer at Probably Genetic:\nAn engaging and supportive team all on a mission to improve lives\n\nFair and equitable compensation with competitive early-stage equity grants\n\nGenerous Flexible Time off policy, that we actually use\n\nParental Leave Benefits (12 weeks for both birthing and non-birthing)\n\nHybrid, flexible work with high-trust and autonomy\n\nA bright, inviting, pet-friendly office in Downtown SF near transit\n\nCompany-sponsored team lunch every Thursday\n\nA “work from anywhere” policy, up to 4 weeks a year\n\nRegular team retreats in exciting destinations\n\nHealth Benefits including medical, dental, vision, therapy, FSA, and 401k\n\nAnd so much more!\n\nProbably Genetic is committed to fostering a welcoming and inclusive work environment for people of all genders, sexuality, ethnicity, socioeconomic background and life experiences. We urge candidates of all backgrounds to apply. If you require specific accommodations as you interview or consider working with us, please let us know.","description_format":"text","description_chars":5033,"description_truncated":false,"requirements":{"experience_years_min":4,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["401k plan","Equity","Flexible schedule","Flexible time off","Parental leave"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Genomics & Genetic Testing"],"lifecycle":[{"event":"open","at":"2026-11-10T02:49:27Z"}],"visa":[],"liveness":{"score":86,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.86,"p_room":1,"age_days":0,"expected_fill_days":127,"reasons":["conf:2","win:early"],"computed_at":"2026-11-10T04:55:13Z"},"pay":{"stated_usd_annual":200000,"is_top_pay":true},"html_url":"https://alion.io/job/probably-genetic-senior-computational-biologist","json_url":"https://alion.io/job/probably-genetic-senior-computational-biologist.json","meta":{"generated_at":"2026-11-10T04:55:13Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":11441,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-11T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.1,"usd":0.01,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":685488},"rest":"https://alion.io/mcp/rest/get_company?id=685488"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fprobably-genetic-senior-computational-biologist"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":2,"usd":0.2},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fprobably-genetic-senior-computational-biologist"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.1,"usd":0.01},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fprobably-genetic-senior-computational-biologist"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/probably-genetic-senior-computational-biologist\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fprobably-genetic-senior-computational-biologist"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3999428}},{"tool":"search_jobs","arguments":{"company":"probablygenetic.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3999428},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. Docs: https://alion.io/developers"}}