{"id":2928582,"url":"https://alion.io/job/proclinical-principal-scientist-quantitative-bioanalysis","title":"Principal Scientist, Quantitative Bioanalysis","company":{"id":2116512,"name":"Proclinical","domain":"proclinical.com","url":"https://alion.io/company/proclinical","size_band":"201-500","is_staffing_agency":true,"employer_type":"agency","is_intermediary":false,"listed_via":null,"ats_vendor":"Schema","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":"lead","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Malvern, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":69000,"max_usd":183000,"period":"year","method":"role_seniority_country_remote_cell","sample_n":584},"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-10-20T09:52:47Z","employer_posted_date":"2026-10-20","last_verified_at":"2026-10-23T16:38:15Z","board_verified":true,"closed_at":null,"days_open":3,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":3},"description":"Principal Scientist- Permanent - Malvern, PA\nReady to lead cutting-edge LC-MS bioanalysis programmes that accelerate the development of life-changing biologic therapies?\nProclinical is seeking a highly motivated and experienced Principal Scientist to provide scientific leadership in the development, validation, and application of LC-MS-based quantitative bioanalytical methods supporting large molecule therapeutics.\nPrimary Responsibilities:\nThe successful candidate will serve as a technical expert in mass spectrometry leading complex projects, representing the Company in client interactions and troubleshooting methods.\nSkills & Requirements:\nExtensive experience in development and validation of oligonucleotide, protein or antibody-drug conjugate (ADC) therapeutics for nonclinical and clinical bioanalysis in a GLP environment.\nExperience in a contract research organization (CRO) environment or as a scientific expert in pharma.\nKnowledge of hybrid ligand-binding assay (LBA) and LC-MS approaches for large molecule quantitation.\nHands-on experience with triple quadrupole mass spectrometry platforms and quantitative LC-MS workflows.\nProven ability to lead scientific programs.\nStrong knowledge of bioanalytical method development, validation, and regulatory guidance (FDA, EMA, ICH, M10) for supporting clinical bioanalysis programs.\nExcellent communication, problem-solving, and client-facing skills.\nExperience with high-resolution mass spectrometry (HRMS) platforms such as Orbitrap or QTOF systems.\nExperience with representing the LC-MS discipline to the external scientific community or clients.\nThe Principal Scientist's responsibilities will be:\nServe as a scientific leader for method development and validation of LC-MS-based quantitative bioanalysis programs supporting preclinical and clinical studies. \nExperience in GLP method validation is a must.\nDesign, develop, optimize, validate, and troubleshoot quantitative bioanalytical methods for large molecule therapeutics in biological matrices.\nProvide technical oversight and interpretation of complex bioanalytical data to support pharmacokinetic (PK), toxicokinetic (TK), and biomarker studies.\nLead multiple client programs simultaneously and serve as a scientific point of contact for study design, strategy, and data interpretation.\nDrive innovation and implementation of advanced LC-MS technologies, workflows, and automation strategies.\nCollaborate cross-functionally with project management, laboratory operations, quality assurance, and regulatory teams to ensure successful study execution.\nAuthor and review study plans, validation protocols, reports, regulatory submissions, scientific publications, and standard operating procedures.\nEvaluate emerging technologies and contribute to strategic expansion of bioanalytical capabilities.\nPresent scientific findings to clients, senior leadership, and at external scientific conferences.\n\nIf you are having difficulty in applying or if you have any questions, please contact Shannon Briggs at .\nIf you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page.\nProclinical is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Proclinical is acting as an Employment Agency in relation to this vacancy.\nBy submitting this application, you confirm that you've read and understood our privacy policy, which informs you how we process and safeguard your data - https://www.proclinical.com/privacy-policy","description_format":"text","description_chars":3655,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":null,"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Laboratory Equipment"],"lifecycle":[{"event":"open","at":"2026-10-20T14:06:25Z"}],"visa":[],"liveness":{"score":54,"band":"ok","label":"Likely open","p_open":1,"p_active":0.542,"p_room":1,"age_days":2,"expected_fill_days":45,"reasons":["conf:0","agency","velocity","win:early","comp:brand"],"computed_at":"2026-10-23T05:54:15Z"},"pay":null,"html_url":"https://alion.io/job/proclinical-principal-scientist-quantitative-bioanalysis","json_url":"https://alion.io/job/proclinical-principal-scientist-quantitative-bioanalysis.json","meta":{"generated_at":"2026-10-23T21:17:39Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":3195,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-24T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":2116512},"rest":"https://alion.io/mcp/rest/get_company?id=2116512"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fproclinical-principal-scientist-quantitative-bioanalysis"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fproclinical-principal-scientist-quantitative-bioanalysis"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fproclinical-principal-scientist-quantitative-bioanalysis"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/proclinical-principal-scientist-quantitative-bioanalysis\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fproclinical-principal-scientist-quantitative-bioanalysis"}]}