{"id":3134250,"url":"https://alion.io/job/proclinical-senior-director-dmpk","title":"Senior Director, DMPK","company":{"id":2116512,"name":"Proclinical","domain":"proclinical.com","url":"https://alion.io/company/proclinical","size_band":"201-500","is_staffing_agency":true,"employer_type":"agency","is_intermediary":false,"listed_via":null,"ats_vendor":"Schema","truth_index":null},"role":"Biotech","role_family":"Biotech","seniority":"head","employment_type":"full_time","work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":230000,"max":300000,"currency":"EUR","period":"year","gross":null,"usd_annual":336502},"salary_estimate":null,"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-10-22T16:14:00Z","employer_posted_date":"2026-10-22","last_verified_at":"2026-10-26T11:07:47Z","board_verified":true,"closed_at":null,"days_open":3,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":3},"description":"Senior Director, DMPK\nLocation: Bay Area, California\nWorking model: Hybrid, two days per week on site\nEmployment type: Full-time\nSector: Clinical-stage biotechnology\nFocus: Small molecules\nCan you lead the DMPK strategy that transforms promising science into clinical success?\nAn exciting opportunity has arisen for an accomplished Senior Director, DMPK to join a well-funded, clinical-stage biotechnology company developing innovative therapies for immune-mediated and inflammatory diseases.This is a highly influential scientific leadership position with responsibility for shaping and executing drug metabolism and pharmacokinetics strategies across a growing portfolio of small molecule programmes. You will guide assets from early discovery and clinical candidate selection through first-in-human studies and subsequent clinical development.\nWorking across discovery, translational science, non-clinical development and clinical teams, you will ensure that high-quality ADME, pharmacokinetic and PK/PD data are translated into clear programme decisions. The position offers considerable scientific visibility, broad cross-functional influence and the opportunity to make a meaningful impact within an agile, growth-stage biotechnology environment.\nKey Responsibilities\nEstablish and execute integrated DMPK, ADME and PK/PD strategies across discovery and development programmes.\n\nProvide scientific leadership and DMPK expertise within multidisciplinary project teams.\n\nDesign, oversee and interpret in vitro and in vivo DMPK studies.\n\nGuide clinical candidate selection and the progression of small molecule assets into development.\n\nIntegrate DMPK data into programme strategy and evidence-based decision-making.\n\nDevelop translational strategies and generate first-in-human dose projections.\n\nPartner with medicinal chemistry, pharmacology, toxicology, CMC, translational and clinical colleagues.\n\nBuild and manage productive relationships with CROs, consultants and external scientific collaborators.\n\nAuthor and review pharmacokinetic and DMPK content for INDs, CTAs, Investigator's Brochures and marketing applications.\n\nPresent scientific findings, strategic recommendations and programme risks to senior leadership and external stakeholders.\n\nMaintain rigorous scientific, documentation and reporting standards across the DMPK function.\n\nAbout You\nYou are an established DMPK leader with experience of advancing small molecule drug candidates from discovery through clinical development. You combine strong scientific expertise with the commercial and strategic judgement required to influence programme direction and organisational decision-making.\nYou will bring:\nA PhD in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences or a related discipline.\n\n10+ years of industry DMPK experience within biotechnology or pharmaceutical drug development.\n\nDeep expertise in small molecule drug discovery and development.\n\nDemonstrated experience supporting clinical candidate selection and progression into the clinic.\n\nStrong knowledge of ADME, pharmacokinetics, PK/PD modelling and translational sciences.\n\nExperience developing first-in-human dose projections and translational development strategies.\n\nExpertise preparing regulatory documentation and supporting interactions with health authorities.\n\nA track record of leading programmes and influencing cross-functional teams within innovative drug development environments.\n\nWhy Join?\nThis role offers the opportunity to:\nShape DMPK strategy across multiple discovery and clinical-stage programmes.\n\nPlay a key role in progressing innovative therapies for immune-mediated and inflammatory diseases.\n\nOperate as a recognised scientific leader with significant influence across the organisation.\n\nWork alongside experienced scientists and drug developers in a highly collaborative environment.\n\nJoin a well-funded biotechnology company where individuals can directly impact programme success and company growth.\n\nBenefit from a flexible hybrid work model in Palo Alto.\n\nCompensation & Benefits\nA highly competitive compensation package is available and will be aligned with experience, expertise and market benchmarks. The package may include:\nCompetitive base salary - €230,000 - €300,000\n\nAnnual performance bonus\n\nEquity participation / long-term incentives\n\nMedical, dental and vision coverage\n\nRetirement savings programme\n\nGenerous paid time off\n\nPaid parental leave\n\nLife and disability insurance\n\nComprehensive wellness programmes\n\nIf you are having difficulty in applying or if you have any questions, please contact Neil Walton \nIf you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page.\nProclinical is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Proclinical is acting as an Employment Agency in relation to this vacancy.\nBy submitting this application, you confirm that you've read and understood our privacy policy, which informs you how we process and safeguard your data - https://www.proclinical.com/privacy-policy","description_format":"text","description_chars":5233,"description_truncated":false,"requirements":{"experience_years_min":10,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity","Hybrid work","Parental leave"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Drug Discovery"],"lifecycle":[{"event":"open","at":"2026-10-23T05:03:26Z"}],"visa":[],"liveness":{"score":54,"band":"ok","label":"Likely open","p_open":1,"p_active":0.542,"p_room":1,"age_days":3,"expected_fill_days":45,"reasons":["seen:3","agency","velocity","win:early","comp:brand"],"computed_at":"2026-10-26T05:57:25Z"},"pay":{"stated_usd_annual":336502,"is_top_pay":true},"html_url":"https://alion.io/job/proclinical-senior-director-dmpk","json_url":"https://alion.io/job/proclinical-senior-director-dmpk.json","meta":{"generated_at":"2026-10-26T12:23:18Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":16911,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-27T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":2116512},"rest":"https://alion.io/mcp/rest/get_company?id=2116512"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fproclinical-senior-director-dmpk"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fproclinical-senior-director-dmpk"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fproclinical-senior-director-dmpk"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/proclinical-senior-director-dmpk\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fproclinical-senior-director-dmpk"}]}