{"id":1265652,"url":"https://alion.io/job/profluent-senior-research-associate-technology-development","title":"Senior Research Associate - Technology Development","company":{"id":48175,"name":"Profluent","domain":"profluent.bio","url":"https://alion.io/company/profluent","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"A","score":89,"open_postings":11,"ghost_share":0,"stale_share":0.455,"repost_share":0,"time_to_fill_p50_days":null,"computed_at":"2026-09-27T05:45:00Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"explicit","locations":["Emeryville, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":104000,"max":110000,"currency":"USD","period":"year","gross":null,"usd_annual":110000},"salary_estimate":null,"experience_years_min":2,"visa_sponsorship":true,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Machine Learning","optional":false},{"name":"Python","optional":false},{"name":"Spark","optional":false}],"status":"live","first_seen_at":"2026-09-25T17:52:34Z","employer_posted_date":"2026-09-25","last_verified_at":"2026-09-28T02:35:47Z","board_verified":true,"closed_at":null,"days_open":2,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":2},"description":"Profluent is the frontier AI lab for biology. Profluent builds powerful foundation models for all of life's molecules, unlocking solutions that transform medicine, agriculture, and beyond. Founded in 2022 and headquartered in Emeryville, CA, Profluent is backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures and has raised over $150M to date.\nProfluent is seeking a creative, passionate, and detail-oriented individual to join our Technology Development team and contribute to the development and application of high-throughput workflows for genome editing.\nThis role has two primary components: \nYou will conceptualize, develop, execute, and scale arrayed assays for gene editing in mammalian cells for a well-scoped, external facing project. \nYou will collaborate internally to develop and improve novel and existing assays and processes.\nIn both areas, you will work at the intersection of biology, automation, and data to advance cutting-edge research. You will drive impactful projects and contribute to the conception, design, analysis, and interpretation of experiments. You will bring creative, literature-informed problem-solving to early-stage conceptualization and troubleshooting, and apply a detail-oriented, data-driven mindset during late-stage optimization.\nAs part of the team, you will excel as both an individual contributor and a collaborator, actively supporting shared goals while learning from and contributing to new technical and conceptual areas. Your adaptability and curiosity will help advance Profluent’s mission to develop transformative gene-editing technologies.\nWe welcome candidates from diverse backgrounds who share our commitment to revolutionizing biology, driving meaningful innovation, and making a lasting impact on global healthcare. \nThis role offers a unique opportunity to shape the future of AI-driven protein design while collaborating with a dynamic, interdisciplinary team of experts in machine learning, protein engineering, cell biology, and gene editing.\nResponsibilities\nDevelop, execute, and automate arrayed and pooled mammalian cell-based gene editing assays\nDesign and execute low and high throughput plasmid cloning campaigns for construction of DNA libraries\nLeverage variety of readouts, including plate-based assays, flow cytometry, and next generation sequencing (NGS)\nPerform mammalian cell culture and transfection\nPrecisely track and document experimental samples, assay data, and results\nAnalyze experimental data and interpret results\nPresent experimental results to colleagues in team and cross-team meetings\nContribute to lab maintenance and adhere to EHS standards \nQualifications\n\nBS and in Molecular Biology, Biochemistry, Cell Biology, or a related field and 4 years or MS in in Molecular Biology, Biochemistry, Cell Biology, or a related field and 2 years of relevant industry research experience \nExtensive, hands-on experience with mammalian and bacterial cell culture and molecular biology\nExperience with flow cytometry \nExcellent communication skills and the ability to work collaboratively across interdisciplinary teams\nStrong organizational skills to accurately track laboratory samples and experimental data\nPreferences\nExperience with CRISPR and/or mammalian cell-based gene editing assays\nExperience with next generation sequencing wet lab and computational workflows/analysis\nExperience with high throughput screening workflows\nExperience with process development and and structured collaboration\nExperience processing and analyzing large experimental datasets (i.e. Python or JMP)\nWhat We Offer \nHigh-growth opportunity with meaningful impact on the future of protein design\nCompetitive compensation package with equity participation\n401(k) with a strong employer match\nComprehensive benefits including health/dental/vision insurance\nGenerous PTO policy and commitment to work-life balance\nProfessional development opportunities in a cutting-edge field at the intersection of AI and biology\nProfluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.\nWork Authorization Requirement\nApplicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.\nEmployment Eligibility Verification\nLegal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.\nHiring Salary Range\n$104,000—$110,000 USD\nNOTICE TO STAFFING AND SEARCH FIRMS: Profluent does not accept unsolicited candidate submissions. We ask that agencies refrain from sending resumes to our careers inbox, hiring managers, or any Profluent employee. Any resume submitted without a signed agreement and an active search request from our Talent team will be treated as the property of Profluent, and no placement fee will be owed.","description_format":"text","description_chars":5548,"description_truncated":false,"requirements":{"experience_years_min":2,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":null,"security_clearance":false,"languages":[]},"benefits":["Equity","Professional development","Vision insurance"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Biotechnology","Cell & Gene Therapy"],"lifecycle":[{"event":"open","at":"2026-09-25T22:30:42Z"}],"liveness":{"score":86,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.86,"p_room":1,"age_days":1,"expected_fill_days":42,"reasons":["conf:0","win:early"],"computed_at":"2026-09-27T05:45:00Z"},"pay":{"stated_usd_annual":110000,"is_top_pay":false},"html_url":"https://alion.io/job/profluent-senior-research-associate-technology-development","json_url":"https://alion.io/job/profluent-senior-research-associate-technology-development.json","meta":{"generated_at":"2026-09-28T04:34:23Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","usage":{"tier":"crawler","counted_by":"address","units_charged":1,"used_today":2865,"day_limit":5000,"remaining_today":2135,"minute_limit":60,"resets_at":"2026-09-29T00:00:00Z"}}}