Analytical Scientist I

The Analytical Science team is looking for a talented scientist to collaboratively work with our R&D and Bioprocess teams to quantify and characterize broad classes of therapeutic proteins. A successful candidate will bring an outcome-oriented skillset to recombinant protein quantification and characterization. You will work collaboratively with our teams to produce and purify diverse proteins from cell culture processes and be comfortable conducting a wide range of protein quality assessments.

Key Responsibilities

• Collaborate with cell line development and bioprocess teams for delivery of key internal technology programs and external customer projects.
• Develop, optimize, and validate assays for protein titer and quality for broad classes of recombinant therapeutic proteins.
• Plan and execute experimentation to understand protein quality through cell line, upstream and downstream process development.
• Execute, summarize, interpret, and present routine and complex therapeutic protein characterizations.
• Qualify and validate analytical procedures to compliance standards, upholding rigorous standards for execution and documentation.
• Routinely operate, maintain, and troubleshoot analytical instrumentation (HPLCs, FPLCs, mass spectrometers).
• Author, review, and implement methods, protocols, validations, and standard operating procedures. Ensure processes are followed in accordance with these standards.

About You

• Hold a PhD in Analytical Chemistry, Molecular Biology, Biochemistry, Pharmaceutical Sciences, with 1+ years of biologics industry experience. Candidates without a PhD but with similar industry experience are encouraged to apply.
• Have illustrated experience in therapeutic protein characterization approaches (eg. HPLC, SDS, CE, cIEF, LC-MS).
• Have illustrated the ability to develop, execute, and interpret intact mass, sequence confirmation, and PTM analysis (e.g., glycosylation, disulfide mapping, peptide mapping) through mass spectrometry.
• Have illustrated the ability to develop, execute, and interpret aggregation and charge variant characterizations for biologics.
• Have experience in the development and execution of GLP-compliant methods characterizing protein quality attributes across a wide range of therapeutic classes.
• Have hands-on experience operating LC-MS. Experience with Agilent QTOF instrumentation applied to assay protein quality is a plus, including familiarity with proteomic software.
• Are highly motivated to deliver successful outcomes for internal and external clients.
• Are excited to work with internal and external clients to deliver project excellence.

  Have strong communication skills and are comfortable teaching and sharing knowledge at multiple levels of technical detail.