{"id":682246,"url":"https://alion.io/job/prolific-machines-analytical-scientist-i","title":"Analytical Scientist I","company":{"id":685503,"name":"Prolific Machines","domain":"prolific-machines.com","url":"https://alion.io/company/prolific-machines","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Lever","truth_index":null},"role":"Biotech","role_family":"Biotech","seniority":"junior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Emeryville, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":120000,"max":140000,"currency":"USD","period":"year","gross":null,"usd_annual":140000},"salary_estimate":null,"experience_years_min":1,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Cell Culture","optional":false},{"name":"GLP","optional":false},{"name":"HPLC","optional":false},{"name":"Mass Spectrometry","optional":false}],"status":"live","first_seen_at":"2026-09-08T23:03:51Z","employer_posted_date":"2026-09-08","last_verified_at":"2026-10-22T02:14:29Z","board_verified":true,"closed_at":null,"days_open":43,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":43},"description":"The Analytical Science team is looking for a talented scientist to collaboratively work with our R&D and Bioprocess teams to quantify and characterize broad classes of therapeutic proteins. A successful candidate will bring an outcome-oriented skillset to recombinant protein quantification and characterization. You will work collaboratively with our teams to produce and purify diverse proteins from cell culture processes and be comfortable conducting a wide range of protein quality assessments.\nKey Responsibilities\nCollaborate with cell line development and bioprocess teams for delivery of key internal technology programs and external customer projects. \nDevelop, optimize, and validate assays for protein titer and quality for broad classes of recombinant therapeutic proteins. \nPlan and execute experimentation to understand protein quality through cell line, upstream and downstream process development.\nExecute, summarize, interpret, and present routine and complex therapeutic protein characterizations.\nQualify and validate analytical procedures to compliance standards, upholding rigorous standards for execution and documentation.\nRoutinely operate, maintain, and troubleshoot analytical instrumentation (HPLCs, FPLCs, mass spectrometers).\nAuthor, review, and implement methods, protocols, validations, and standard operating procedures. Ensure processes are followed in accordance with these standards.\nAbout You\nHold a PhD in Analytical Chemistry, Molecular Biology, Biochemistry, Pharmaceutical Sciences, with 1+ years of biologics industry experience. Candidates without a PhD but with similar industry experience are encouraged to apply. \nHave illustrated experience in therapeutic protein characterization approaches (eg. HPLC, SDS, CE, cIEF, LC-MS). \nHave illustrated the ability to develop, execute, and interpret intact mass, sequence confirmation, and PTM analysis (e.g., glycosylation, disulfide mapping, peptide mapping) through mass spectrometry. \nHave illustrated the ability to develop, execute, and interpret aggregation and charge variant characterizations for biologics. \nHave experience in the development and execution of GLP-compliant methods characterizing protein quality attributes across a wide range of therapeutic classes.\nHave hands-on experience operating LC-MS. Experience with Agilent QTOF instrumentation applied to assay protein quality is a plus, including familiarity with proteomic software. \nAre highly motivated to deliver successful outcomes for internal and external clients.\nAre excited to work with internal and external clients to deliver project excellence.Have strong communication skills and are comfortable teaching and sharing knowledge at multiple levels of technical detail.","description_format":"text","description_chars":2740,"description_truncated":false,"requirements":{"experience_years_min":1,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Synthetic Biology","Drug Discovery"],"lifecycle":[{"event":"open","at":"2026-09-10T23:41:54Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 1","filings_12m":1,"filings_prev_12m":1,"green_card_filings_12m":0,"median_offered_wage_usd":112500,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":21,"band":"cold","label":"Long shot","p_open":1,"p_active":0.57,"p_room":0.36,"age_days":42,"expected_fill_days":28,"reasons":["conf:2","win:tail","crowd:junior"],"computed_at":"2026-10-21T05:46:15Z"},"pay":{"stated_usd_annual":140000,"is_top_pay":false},"html_url":"https://alion.io/job/prolific-machines-analytical-scientist-i","json_url":"https://alion.io/job/prolific-machines-analytical-scientist-i.json","meta":{"generated_at":"2026-10-22T02:27:50Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":1948,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-23T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":685503},"rest":"https://alion.io/mcp/rest/get_company?id=685503"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fprolific-machines-analytical-scientist-i"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fprolific-machines-analytical-scientist-i"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fprolific-machines-analytical-scientist-i"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/prolific-machines-analytical-scientist-i\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fprolific-machines-analytical-scientist-i"}]}