{"id":453584,"url":"https://alion.io/job/proxima-technologies-directorchemistry","title":"Director,Chemistry","company":{"id":77316,"name":"Proxima Technologies","domain":"proxima.ae","url":"https://alion.io/company/proxima-ae","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Ashby","truth_index":{"grade":"A","score":88,"open_postings":7,"ghost_share":0,"stale_share":0.286,"repost_share":0,"time_to_fill_p50_days":161,"computed_at":"2026-11-04T06:34:25Z"}},"role":"Sales","role_family":"Sales","seniority":"head","employment_type":"full_time","work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Boston, United States","New York, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":147000,"max_usd":289000,"period":"year","method":"role_seniority_country_remote_cell","sample_n":2908},"experience_years_min":8,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Machine Learning","optional":false},{"name":"Mass Spectrometry","optional":false}],"status":"live","first_seen_at":"2026-08-26T17:58:32Z","employer_posted_date":"2026-08-26","last_verified_at":"2026-11-04T23:09:00Z","board_verified":true,"closed_at":null,"days_open":70,"trust":{"level":"ok","repost_count":0,"flags":[],"days_open":69},"description":"About Proxima\nProxima is a frontier AI and data generation company discovering the next generation of proximity therapeutics by making protein interactions programmable. Our platform brings together foundation-model machine learning, a scalable data generation engine, and a partnership track record exceeding $5B in collaborations across the world’s leading biopharma and tech organizations. We’ve recently closed an oversubscribed $80M seed round with an elite group of VCs including DCVC, NVIDIA’s NVentures, AIX, Yosemite among others.\nNeo-1 is our all-atom foundation model that combines state-of-the-art structure prediction and molecular generation in a single system. Neo-1 enables rapid exploration of chemical and structural space for high value, previously intractable targets, and in particular unlocks small molecule proximity therapeutics like molecular glues with AI for the first time.\nIn parallel, we are developing an advanced structural interactomics platform built on proprietary XLMS technology and our Boston lab equipped with next-generation mass spectrometry instrumentation. This platform produces proteome-scale maps of protein interactions and helps identify small molecules that modulate proximity. Together with Neo-1, it creates an integrated system capable of co-folding protein complexes while generating candidate small molecules to influence those interactions.\nProximity-based therapeutics represent one of the most promising frontiers in modern drug discovery with the potential to treat previously intractable diseases and target 'undruggable' proteins. Our technology combines proteome-scale structural data with state-of-the-art generative AI foundation models, and coupled with our talented team of scientists and engineers we are uniquely well-positioned to discover and develop a new class of medicines. Come join us!\nThe Role\nWe are building out our chemistry function in Boston and hiring a Senior Chemist to drive the chemistry on our pipeline programs.\n\nYou will own compound design and synthesis for a discovery program from hit identification through lead optimization, working shoulder to shoulder with our Boston biology team. You will also work directly with our ML scientists, pressure-testing what Neo-1 generates against what is actually synthesizable and actually worth making.\n\nWhat You'll Do\nOwn compound design and SAR strategy for a pipeline program, from hit identification through lead optimization\n\nUse structure to drive the chemistry: co-crystal structures, homology and docking models, and physics-based methods where they earn their keep\n\nWork at the chemistry/biology interface, interpreting pharmacology data directly and shaping what gets tested next\n\nDesign synthetic routes and direct external synthesis, staying close to the chemistry and solving synthetic challenges\n\nDrive DMTA cycles alongside biology and DMPK, prioritizing compounds on potency, selectivity, and developability\n\nSolve real problems: potency, selectivity, permeability, metabolic stability, solubility, and property space beyond Rule of 5\n\nPressure-test Neo-1's output for synthetic tractability and chemical relevance, and feed results back so the models improve\n\nManage CRO chemistry end to end: scoping, route review, quality, timelines, cost\n\nBuild data packages that support internal go/no-go calls and pharma partner deliverables\n\nWhat We're Looking For\nPhD in organic chemistry\n\nRoughly 8-12 years of post-PhD experience in medicinal chemistry or chemical biology, with extensive synthetic chemistry experience\n\nDemonstrated structure-based drug design capability: you have used structures and models to make chemistry decisions that improved potency or selectivity\n\nPractical computational chemistry skills built through discovery work rather than from a purely computational background\n\nBiology fluency: you can read a pharmacology package, reason about late-stage pharmacology and translational implications, and hold your own with biologists\n\nProgram experience on enzyme and/or receptor targets (GPCRs, nuclear receptors)\n\nStrong synthetic chemistry fundamentals and sound judgment on route design\n\nExperience directing CRO chemistry and holding external partners to high standards\n\nComfortable in a small, fast, resource-constrained team where you own the chemistry end to end","description_format":"text","description_chars":4331,"description_truncated":false,"requirements":{"experience_years_min":8,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Managed IT Services (MSP)","Systems Integrators","Video Surveillance"],"lifecycle":[{"event":"open","at":"2026-09-06T09:11:35Z"}],"visa":[],"liveness":{"score":61,"band":"ok","label":"Likely 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