{"id":2946740,"url":"https://alion.io/job/quantum-si-senior-scientist-biochemistry","title":"Senior Scientist, Biochemistry","company":{"id":689284,"name":"Quantum-Si","domain":"quantumsi.ai","url":"https://alion.io/company/quantumsi","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"explicit","locations":["Branford, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":135000,"max":165000,"currency":"USD","period":"year","gross":null,"usd_annual":165000},"salary_estimate":null,"experience_years_min":7,"visa_sponsorship":true,"relocation_package":false,"has_equity":true,"technologies":[],"status":"live","first_seen_at":"2026-10-20T15:03:34Z","employer_posted_date":"2026-10-20","last_verified_at":"2026-10-21T06:20:09Z","board_verified":true,"closed_at":null,"days_open":0,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":0},"description":"The Senior Scientist, Biochemistry will lead development and implementation of high-throughput biochemical assays to discover and characterize aminopeptidases with properties relevant to next-generation protein sequencing. The role will focus on screening diverse aminopeptidase candidates for activity, selectivity, kinetics, robustness, and performance across a broad range of substrates. The successful candidate will combine strong expertise in enzymology, protein biochemistry, assay development, and quantitative data analysis to advance enzyme reagents. \nCore Responsibilities \nDevelop workflows and progression criteria for primary screening, hit confirmation, characterization, ranking, and advancement of enzyme candidates. \nIntegrate screening assays into enzyme-evolution pipelines and coordinate the advancement of promising candidates into downstream development and sequencing-assay evaluation. \nDevelop clear, reusable reporting toolsto communicate screening results, candidate recommendations, and pipeline status. \nPurify and characterize proteins to support assay development and candidate evaluation. \nUse laboratory automation and data-analysis tools to increase screening throughput, consistency, and traceability. \nContribute to a culture of scientific rigor, execution, continuous learning, and knowledge sharing. \nDocument and transfer selected assays to downstream QC teams to support the release of production enzymes. \nRequired Qualifications \nM.S. with 7+ years or Ph.D. with 3+ years of relevant academic or industry experience in protein biochemistry, enzymology, biophysics, biotechnology, chemical biology, or a related field. \nDemonstrated ability to independently and creatively design, optimize, and troubleshoot biochemical assays for challenging enzymology applications. \nStrong foundation in enzyme kinetics, protein-substrate interactions, assay controls, and quantitative interpretation of biochemical data. \nExperience developing enzyme-activity assays using fluorescence, absorbance, polarization, chromatography, or related readouts. \nAbility to analyze large experimental datasets and use computational or statistical tools to support assay optimization and candidate selection. \nAbility to learn, set up, and operatecomplex instrumentation and laboratory automation. \nAbility to plan and execute multiple scientific workstreams while maintaininghigh standardsfor experimental design, documentation, and data quality. \nExcellent organizational, analytical, communication, collaboration, and presentation skills. \nPreferred Qualifications \nExperience developing and scaling high-throughput enzyme-screening workflows, including assay miniaturization and automation. \nExpertisein aminopeptidases, proteases, exopeptidases, or other proteolytic enzymes. \nExperience evaluating enzyme activity across diverse peptide substrates and sequence contexts. \nExperience with rapid-kinetics methods and instrumentation, including stopped-flow or quench-flow systems. \nHands-on experience with protein expression, purification, and characterization using chromatography systems such as AKTA and HPLC. \nExperience with fluorescence polarization, fluorimeters such as Fluoromax, LC-MS, or other orthogonal methods for enzyme characterization. \nExperience with peptide synthesis, peptide conjugation, protein labeling, or single-molecule assay development. \nExperience with labelingand evaluation ofproteins using ensemble and single-molecule assays. \nThe estimated base salary range for this position in the United States is $135,000- $165,000. In addition to base salary, full-time employees are eligible to participate in Quantum-Si's discretionary annual bonus program and may receive equity awards as part of the total compensation package.\nActual compensation will be determined based on a variety of factors, including, but not limited to, the position level, relevant skills, knowledge, experience, qualifications, geographic location, internal equity, and market data.\nQuantum-Si also offers a competitive benefits package designed to support employees' health, well-being, work-life balance, and family needs. Benefits include:\nComprehensive medical, dental, and vision insurance coverage\nHealth Savings Account (HSA) and Flexible Spending Account (FSA) options, where applicable\nCompany-paid life and accidental death & dismemberment (AD&D) insurance\nShort-term and long-term disability coverage\nEmployee Assistance Program (EAP) resources to support personal and professional well-being\nDiscretionary paid time off and company-paid holidays\nParental leave to support employees welcoming and caring for a new child\n401(k) retirement savings plan with both pre-tax and Roth contribution options\nAdditional Information\nCandidates must be authorized to work in the United States. Quantum-Si does not provide employment-based immigration sponsorship of any kind for this position, including support for applicants currently pursuing permanent residency (Green Card sponsorship).\nQuantum-Si does not accept unsolicited agency resumes.\nQuantum-Si is an E-Verify and equal opportunity employer regardless of race, color, ancestry, religion, gender, national origin, sexual orientation, age, citizenship, marital status, disability or Veteran status. All your information will be kept confidential according to EEO guidelines","description_format":"text","description_chars":5357,"description_truncated":false,"requirements":{"experience_years_min":7,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Continuous learning","Equity","Insurance coverage","Parental leave","Retirement plans","Vision insurance"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Laboratory Equipment"],"lifecycle":[{"event":"open","at":"2026-10-20T18:52:18Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 1","filings_12m":1,"filings_prev_12m":2,"green_card_filings_12m":0,"median_offered_wage_usd":157500,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":86,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.86,"p_room":1,"age_days":0,"expected_fill_days":36,"reasons":["conf:2","win:early"],"computed_at":"2026-10-21T05:46:15Z"},"pay":{"stated_usd_annual":165000,"is_top_pay":true},"html_url":"https://alion.io/job/quantum-si-senior-scientist-biochemistry","json_url":"https://alion.io/job/quantum-si-senior-scientist-biochemistry.json","meta":{"generated_at":"2026-10-21T07:29:49Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":10662,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-22T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":689284},"rest":"https://alion.io/mcp/rest/get_company?id=689284"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fquantum-si-senior-scientist-biochemistry"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fquantum-si-senior-scientist-biochemistry"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fquantum-si-senior-scientist-biochemistry"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/quantum-si-senior-scientist-biochemistry\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fquantum-si-senior-scientist-biochemistry"}]}