{"id":4283245,"url":"https://alion.io/job/rd-partners-principal-scientist-lcmsms","title":"Principal Scientist – LCMS/MS","company":{"id":4541649,"name":"R&D Partners","domain":"r-dpartners.com","url":"https://alion.io/company/r-and-d-partners","size_band":"11-50","is_staffing_agency":false,"employer_type":"staffing","is_intermediary":false,"listed_via":null,"ats_vendor":"Schema","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":"lead","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":[],"countries":[],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":true,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Chromatography","optional":false},{"name":"GCP","optional":false},{"name":"GLP","optional":false},{"name":"GMP","optional":false},{"name":"Mass Spectrometry","optional":false}],"status":"live","first_seen_at":"2026-11-11T00:00:00Z","employer_posted_date":"2026-11-11","last_verified_at":"2026-11-13T21:00:19Z","board_verified":true,"closed_at":null,"days_open":2,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":2},"description":"Ready to lead complex bioanalytical studies and shape the scientific direction of innovative drug development programmes?\nR&D Partners is seeking an experienced Principal Scientist to join a well-established contract research organization specializing in clinical development and bioanalytical services. This hands-on scientific role offers significant ownership across regulated bioanalytical studies, from method development through to study delivery and reporting. The successful candidate will provide technical leadership within small molecule LC-MS/MS bioanalysis, supporting both scientific excellence and the development of junior team members.\nCandidates must have full right to work in the UK to be eligible to apply for this role. Unfortunately, visa sponsorship is not available for this position.\nResponsibilities:\nLead small molecule LC-MS/MS method development, optimization, and validation to ensure robust and compliant bioanalytical assays.\nAct as the technical SME for complex analytical challenges, including chromatographic troubleshooting and extraction techniques (SPE, LLE, protein precipitation).\nProvide scientific oversight of regulated studies, ensuring data integrity, regulatory compliance, and timely project delivery.\nReview and approve protocols, validation reports, SOPs, and other technical documentation.\nMentor laboratory scientists and represent the function during client interactions, audits, and technical discussions.\nKey Skills and Requirements:\nSignificant hands-on experience with triple quadrupole LC-MS/MS in a regulated GLP, GMP, and/or GCP environment.\nProven expertise in small molecule bioanalysis, including method development, validation, and troubleshooting.\nStrong understanding of extraction methodologies, chromatography, and current bioanalytical validation requirements.\nExperience reviewing scientific documentation and ensuring compliance with quality and regulatory standards.\nAbility to lead technical activities, manage competing priorities, and support the development of junior scientists.\nDesirable Qualifications:\nMSc or PhD in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or a related scientific discipline.\nPrevious experience within a CRO, bioanalytical services, or clinical research environment.\nExposure to regulatory inspections, client audits, and quality management systems.\nExperience mentoring, coaching, or providing technical leadership to scientific teams.\nLean Six Sigma or project management training/certification.\nFor more information, please contact Timi Asseez.\nIf you are interested in applying to this exciting opportunity, then please click ‘Apply’ or to speak to one of our specialists visit the ‘Contact Us’ page.\nR&D Partners is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. 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